Medical Radiation Physics Department of Physics Stockholm - PowerPoint PPT Presentation

Medical Radiation Physics Department of Physics Stockholm University

Medical Radiation Physics - MSF Natural Sciences Faculty Medical Radiation Physics Research Group Medical Radiation Physics Department of Oncology-Pathology Division Department of Physics

MSF Postdoc Iuliana Toma-Dasu Helena Sandström Niels Bassler Irena Gudowska Researcher/Collaborator Marta Lazzeroni Ana Ureba Emely Kjellsson Lindblom PhD students MSc students Tomas Palmqvist On average 10 students per year Fredrik Kalholm Filippo Schiavo Wille Häger

Medical Radiation Physics - MSF Education • MSc program in Medical Radiation Physics / Professional education • About 8 MSc students/year on average Research Radiotherapy Radioprotection Radiobiology Dosimetry Imaging

MSF – Medical Radiation Physics • Medical Radiation Physics is a vast and complex translational research topic that deals with radiation physics applied to medicine and biology for medical radiation imaging and radiation therapy - possible collaboration across Fysikum - or beyond Fysikum Radiation Sources Diagnostic Radiology Radiation Interaction Nuclear Medicine Detectors Radiation Therapy Dosimetry Radiation Biology Radiation Protection

MSF - Possible Supervisors at Fysikum ● Potential BSc supervisors at Fysikum, e.g. : ○ Bo Sundborg ○ Michael Odelius ○ Mark Stockett ○ Tony Hansson ○ Henrik Öström ○ Samuel Silverstein ○ Fredrik Hellberg BSc projects topics may involve: ○ Alfredo Ferella ○ … ● any kinds of radiation interaction ● aspects of dosimetry or quantifying radiation fields ● accelerator physics ● interdisciplinary physics topics involving chemistry and/or biology ● detectors ● image analysis ● ...

Examples of BSc projects Title Conducted at Supervisor(s) MSF Supervisor Collision induced fragmentation of thymine clusters Fysikum Mark Stockett Design and construction of a compact radiation dosimeter for calibration Fysikum/RB Samuel Silverstein and mapping of radiation fields in confined irradiation chambers Andrzej Wojcik Spatial frequency-based objective function for optimization of dose UU Anders Ahnesjö heterogeneity in proton grid therapy Simulation of stray radiation in the XFEL undulator using FLUKA Fysikum/MSF Fredrik Hellberg Niels Bassler Characterization of Gafchromic films for applications Fysikum Fredrik Hellberg Investigating the influence of water in lysozyme structure and dynamics Fysikum Foivos Perakis using FT-IR and XRD Dosimetry at the European XFEL using Gafchronic films in beginning of Fysikum Fredrik Hellberg undulator SASE1 Radiation damage to isolated DNA builiding blocks Fysikum Mark Stockett Dosimetric Characterisation of an Alcyon II Medical 60Co Irradiation MSF Niels Bassler Unit Modelling the cell survival using the RCR model MSF Iuliana Toma-Dasu Emely Kjellsson Lindblom

Research at MSF • Radiotherapy - the use of ionising radiation in the management of malign and benign diseases • Radioprotection - assessing and minimising the risk of stochastic detrimental effects of radiation such as induction of cancer after medical radiation exposures - improving preparedness and competence in Sweden to cope with nuclear emergencies • https://www.fysik.su.se/english/medical-radiation-physics/research

Treatment outcome modelling

Customised RT based on functional imaging

MSF – Proton Therapy • Collaboration with Skandion Clinic (Uppsala): ➢ Proton treatment planning comparison to photon therapy ➢ Proton treatment evaluation and optimisation ➢ Radiation protection aspects related to the risk of secondary cancer following proton therapy

Radiation Interaction in Media Development of fast and precise calculation tools for innovative treatment planning Development of radiation detector models for ion radiation, for better dosimetry CRT

Radiation Protection Secondary doses to healthy tissues from radiotherapy and modern imaging techniques => Risk of secondary cancer CRT IMRT From anthropomorphic phantoms to patients

Radiation Protection Dosimetric approaches for protection of people in large-scale nuclear emergencies CRT IMRT Area where the effective dose exceeds 20 µSv in a time interval of 120 minutes after the event of an explosion involving Ir-192 sources.

MSF - Industry and Innovation • Treatment planning based on • Variability in target and OARs tumour hypoxia delineation for SRS • Adaptive RT based on advanced • Robust treatment planning for SRS imaging techniques • Evaluation and selection of treatment plans using functional and radiobiological information

Examples of MSc projects Title Conducted at Supervisor(s) MSF Supervisor A deepened experimental evaluation of radiation detectors to measure NKS Åsa Carlsson Tedgren depth dose curves in water for 106 Ru ophthalmic plaques by use of a new precision setup equipment Clinical evaluation of radioiodine treatments for hyperthyroidism NKS Joachim Nilsson Oscar Ardenfors Jan Calissendorff Image quality and optimisation in conventional diagnostic radiology Huddinge Axel Carlbring Tiina Voima Hellebring Image-derived input functions for non-invasive measurement of cerebral Akademiska Mark Lubberink blood flow using 15 O-water and PET Uppsala Investigating the potential of CBCT for setup and treatment verification Skandion/ Alexandru Dasu Ana Ureba in proton therapy for prostate cancer Akademiska/MSF Ulf Isacsson Silvia Johansson Experimental investigation of the reference dosimetry correction factors NKS Hamza Benmakhlouf for Leksell Gamma Knife Perfexion beams published in TRS-483 Vaiva Kaveckyte Risk of second cancer from proton therapy of breast cancer - impact of Skandion/MSF Alexandru Dasu Iuliana Toma-Dasu physiological and radiobiological uncertainties Jakob Öden Oscar Ardenfors Assessment of image quality in x-ray fluoroscopy based on Model Linköping Mikael Sandborg Observers as an objective measure for quality control and image Erik Tesselaar optimization Clinical optimization of a regularized reconstruction algorithm in PET NKS Alejandro Sanchez Crespo Evaluation of a method for simplified image quality control of dental Danderyd Karin Näsström CBCT units Jerker Edén Strindberg Development of a grid-specific proton optimizer MSF Ana Ureba Thomas Henry

MSF - Fysikum Thank you! MSF