K award NIH Biosketch https://grants.nih.gov/grant s/forms/biosketch.htm Karla Kerlikowske, MD Professor of Medicine and Epidemiology and Biostatistics 1
What is NIH Biographical Sketch? • Highly formatted component of a grant proposal that captures and communicates the PI’s accomplishments and activities as clearly and effectively as possible • A concise “personal narrative” of education, training, experiences, contributions, and leadership in profession/field School of Medicine 2
Why is the NIH Biographical Sketch Needed? Allows PIs to: • Highlight education, training, experiences, and qualifications • Describe magnitude and significance of scientific contributions (plus publications) • Provide significant contributions, relevant experiences, and/or qualifications in the context of the proposed project • Enables reviewers to evaluate experience and qualifications of the PI and scientific team that will execute the grant School of Medicine 3
In a Nut Shell: Your Biosketch Tells Your Story • Who you are • What makes you great for this project • What contributions you have made School of Medicine 4
Components • Limit of 5 pages • A. Personal statement -1/2 pgs. • B. Positions and honors-1/2 pgs. • C. Contributions to Science – 2 pgs. • D. Research support and scholastic performance -2 pgs. School of Medicine 5
NIH biosketch ● Name ● eRA commons ⁃ RMS Research Services Coordinator ● Position Title ● Education ⁃ name and location of the institution ⁃ degree received (if applicable) ⁃ month and year of end date (or expected end date) ⁃ field of study School of Medicine 6
OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Kim, Tiffany Y. eRA COMMONS USER NAME (credential, e.g., agency login): tiffany.kim POSITION TITLE: Assistant Professor of Medicine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) Completion DEGREE INSTITUTION AND LOCATION Date FIELD OF STUDY (if applicable) MM/YYYY University of California, Berkeley BA 05/2007 Molecular and Cell Biology University of Illinois at Chicago MD 05/2011 Medicine University of California, Los Angeles Residency 06/2014 Internal Medicine University of California, San Francisco Certificate 06/2016 Advanced Training in Clinical Research University of California, San Francisco Fellowship 06/2017 Endocrinology San Francisco VA Health Care System Fellowship 06/2019 Women’s Health A. Personal Statement I am an endocrinologist, Assistant Professor of Medicine at the University of California, San Francisco (UCSF) and Staff Physician at the San Francisco VA Health Care System (SFVAHCS). My long-term goal is to become an independent clinical investigator focused on understanding mechanisms of diabetic bone disease and improving the skeletal health of people with type 2 diabetes. I am the Principal Investigator for this K23 proposal, which seeks to examine the role of bone marrow fat in diabetic bone disease. School of Medicine 7
Personal statement • 3-paragraph statement with the following content: • Proposal goal • Relevant experiences on this specific topic or related topic • Leadership qualifications School of Medicine 8
Personal statement tip • Tailor to the grant application • Mention the mechanism of the grant application (e.g., K01) • Speak directly to the purpose of the funding mechanism and proposal goal • Ex: My goal for this proposed NCI Career Development Award (K01, K08) or Transition Award (K22) is to conduct basic, translational, or clinical research to study … while further developing and expanding my (training and) career growth in the field of …(or as a…) or etc. School of Medicine 9
Personal statement tip • Sell your role in the proposed research • Why are you a good fit? • What strengths do you have for the proposal? • Identify yourself – New Investigator – and discuss your future research direction if you are a new investigator • Write in first person and limit your personal statement to 300‒400 words (about half a page) • If someone is mentoring/collaborating with you, include this in the personal statement School of Medicine 10
Personal statement examples • I am a clinician-investigator with a longstanding interest in ….. • I have the expertise, leadership and training in x to carry out the proposed research • I have a broad background in x with specific training in …. • My research has evolved from x experience • As an investigator on x grants, I laid the groundwork for the proposed research by… • I collaborated with x, an expert in x • The proposed studies began under the mentorship of x School of Medicine 11
Personal statement ● Up to 4 publications/research products ● Directly related to research topic ● Articles with co-investigators School of Medicine 12
Personal statement ● Research products ● Audio or video products ● Conference proceedings -- meeting abstracts, posters, presentations ● Patents ● Data and research materials; databases; educational aids or curricula; instruments or equipment; models; protocols; and software or netware School of Medicine 13
A. Personal Statement I am a clinician-investigator with a longstanding interest in improving cancer screening and prevention. My research has evolved from describing the unintended effects of cancer screening to studying novel approaches to screening that are informed by individual risk. My current research focuses on developing risk stratification tools to allow personalization of breast cancer screening and prevention, with a special focus on integrating circulating biomarkers and existing risk prediction models. For instance, I have shown that genetic variants and sex hormones can improve the performance of risk models based on clinical risk factors. As an investigator in the WISDOM Study, an ongoing randomized trial of personalized versus annual breast cancer screening, I am studying how to integrate risk models into clinical decision-making around screening and prevention, and whether this practice improves outcomes. This K08 proposal aims to extend my prior work by developing and validating a risk model that accounts for breast cancer phenotype, enabling screening and prevention to target the aggressive cancers most likely to cause morbidity and mortality. 1. Esserman L, Shieh Y, Thompson I. Rethinking screening for breast cancer and prostate cancer. JAMA. 2009 Oct 21; 302(15):1685-92. PMID: 19843904 2. Shieh Y, Eklund M, Sawaya GF, Black WC, Kramer BS, Esserman LJ. Population-based screening for cancer: hope and hype. Nat Rev Clin Oncol. 2016 Sep; 13(9):550-565. PMID: 27071351 3. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JW, Tice JA, Vachon CM, Cummings SR, Kerlikowske K, Ziv E. Breast cancer risk prediction using a clinical risk model and polygenic risk score. Breast Cancer Res Treat. 2016 Oct; 159(3):513-25. PMID: 27565998. PMCID: PMC5033764 4. Shieh Y, Eklund M, Madlensky L, Sawyer SD, Thompson CK, Stover Fiscalini A, Ziv E, Van't Veer LJ, Esserman LJ, Tice JA. Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial. J Natl Cancer Inst. 2017 Jan; 109(5). PMID: 28130475 School of Medicine 14
Position and Honors ● Positions and Employment ● Other Experience and Professional Memberships ● Honors – clarify what for ● Scholarship ● Traineeship ● Fellowship ● Research Prize School of Medicine 15
Contributions to Science (2 pages) ● Describe up to 5 of your most significant contributions to science –1/2 page, including up to 4 published citations ( PMC or NIHMS ) ● Historical background that frames the scientific problem ● Central finding(s) ● Influence of the finding(s) on the progress of science or the application of those finding(s) to health or technology – So what? ● Your specific role in the described work School of Medicine 16
Contributions to Science ● Historical background that frames the scientific problem ● Similar to background sentence of abstract ● Central finding(s) ● My publication was the first to show …. ● My publication has contributed evidence of …. ● We identified a molecular signature that stratified.... ● We developed a risk model or nomogram to predict...... School of Medicine 17
Contributions to Science ● Influence of the finding(s) on the progress of science or the application of those finding(s) to health or technology • My results contributed to a growing body of evidence that …. • My findings have important implications for clinical care of … • The risk calculator/nomogram/app that I helped is available on the iPhone and facilitates ….. • My contributions have been cited when establishing xx guidelines • This work led to two patents and development of a commercial test School of Medicine 18
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