How Polyubiquitin Chains are Made and Unmade Dr. Irwin A. Rose - PowerPoint PPT Presentation

May 16, 2023 •156 likes •248 views

How Polyubiquitin Chains are Made and Unmade Dr. Irwin A. Rose University of California, Irvine Intermediates in Ub Activation by E1 The Sequence and Distribution of Enzyme Intermediates (Haas & Rose, 1982) How a protein may become

How Polyubiquitin Chains are Made and Unmade Dr. Irwin A. Rose University of California, Irvine
Intermediates in Ub Activation by E1 The Sequence and Distribution of Enzyme Intermediates (Haas & Rose, 1982)
How a protein may become polyubiquinate? (Alberts, The Cell, p. 360)
Test of E1 as a Continuous Ub Source
Ubiquitin Carboxy-terminal Hydrolase ATP AMP + PPi Ub + E 1 SH ES Ub (Spon.) GSH transthiolation GS-Ub (New Enzyme) GSH

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