Dr. Bjrn Jensen Klinik fr Gastroenterologie, Hepatologie und - PowerPoint PPT Presentation

AREVIR 04.05.2019 Analytic treatment interruption after allogeneic CCR5-D32 HSCT for AML in 2013 Update Dr. Björn Jensen Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf

*1969, m HIV diagnosed 10/2010; MSM; - started with TDF/FTC+DRV/r Diagnosis of AML (acute myeloic leukemia, inv16, CBF-MYH11) - in 01/2011

overview I

overview II

overview III

Overview IV

Overview V

HIV reservoirs - follicular - GALT dendritic cells - lymph nodes - macrophages - Liquor/CNS/CSF - resting CD4+ - urogenital tract cells „Can HIV be cured?“ Mario Stevenson Scientific American 299, 78 - 83 (2008)

Virology I

HIV DNA in GALT Yukl et al., JID 2010

Virology II

mVOA

Virology III

Tropism phänotypically (TROPChase)

Serology I

Serology II

Immunology: HIV-1-specific CTL (C. Mummert, S. Bergmann, T.Harrer) Next talk 21

Serology II

Lymph node

M. Bruner et al, 2015

Histology lymph node

Overview

Conclusion  > 6 years after HSCT, almost 6 months ATI  Examining the reservoir and interpreting the results is challenging  ATI is the only way to validate long-term remission (cure?)  Currently HI-VL 2x/week, every 2 weeks larger blood draws (incl. Immunology)  Until now all blood samples negative, patient feels well

Diskussion