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Tuberculosis Mark Oette Klinik fr Allgemeine Innere Medizin, - PowerPoint PPT Presentation

Apr 05, 2023 •255 likes •508 views

Tuberculosis Mark Oette Klinik fr Allgemeine Innere Medizin, Gastroenterologie und Infektiologie Krankenhaus der Augustinerinnen, Kln Conflicts This presentation is free of financial interests Speech honoraria of the last 3

  1. Tuberculosis Mark Oette Klinik für Allgemeine Innere Medizin, Gastroenterologie und Infektiologie Krankenhaus der Augustinerinnen, Köln

  2. Conflicts • This presentation is free of financial interests • Speech honoraria of the last 3 years BMS Falk Gilead Heinen & Löwenstein Hitachi Krankenhäuser

  3. Tbc worldwide

  4. Europe: Transm issible Diseases Inzidence-based DALY/ 100.000, 2009-2013 (1.4 Mio, every 14th person) Cassini A. Eurosurveillance 2018; 23: pii= 17.00454

  6. Europe: Tbc Notification Rate

  7. Tuberculosis Incidence Germany (RKI 2018)

  8. Lung Tbc and Nationality (RKI 2015)

  9. Nationality: Italy

  10. Tuberculosis, Age, and Gender (RKI 2018)

  11. Diagnostics (RKI 2015)

  12. Mortality (RKI 2018)

  13. Resistance (RKI 2018)

  14. Resistance: Italy

  15. Resistance (RKI 2018)

  16. Lange C, et al. Respirology 2018; 23: 656-673

  17. Resistance (MDR)

  18. Europe: Tbc MDR-Rate

  21. Sequencing for Resistance Mutations • Evaluation of 5 software tools to predict resistance (n= 211), 2014 • Comparison with growth cultures/ phenotypic resistance testing • WGS: Illumina MiSec System • Software tools : PhyResSE, Mykrobe Predictor, TB Profiler, TGS-TB and KvarQ • Results: Sensitivity: 74-80% ; Specificity: > 95% Considerable variation between individual drugs Turnaround time (median): 5 vs. 19 days Van Beek J. Clin Microbiol Infect 2019; 25: 82-86

  22. Summary  In Germany approx. 5500 affected persons, slow decline  Epidemiology still driven by migrants  Resistance: Significant problem, rising (not in G)  Transmission of resistance  MDR: Relevant for survival  Resistance testing: Procession time suboptimal  Molecular resistance testing: New applications underway  The future: Resistance testing by NGS standard

  23. Thank you !

  24. Resistance

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