AREVIR, 05.05.2018 RESINA 2001-2018 Dr. Bjrn Jensen Klinik fr - PowerPoint PPT Presentation

AREVIR, 05.05.2018 RESINA 2001-2018 Dr. Björn Jensen Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf

The RESINA Study (Genotypic HIV-Resistance in Treatment-Naives)  Ongoing prospective study in Nordrhein-Westfalen  Inclusion: Untreated HIV-infected subjects before ART initiation  Study period: 2001-2018  Aims of study: – Epidemiology of primary resistance in chronically HIV-infected patients – Evaluation of efficacy of HAART guided by resistance testing – Bioinformatic analysis of resistance data – Subgroup analyses  Classification of resistance: Shafer RW et al., Antiviral Therapy 2009  Until end of April 2018: 4423 patients in 36 centers, 3846 analyzed in this presentation  Funding: – Federal Ministry of Health and Social Security (BMG) – Heinz-Ansmann-Foundation for AIDS-Research

RESINA 2001-2018 Nationality Kamerun Kenia Russland Togo Polen Ghana Nigeria Italien Kongo Brasilien Portugal Türkei 1,43 1,40 1,25 1,04 1,04 1,01 0,96 0,86 0,62 0,60 0,39 1,95 Thailand Griechenland 0,49 1,48 other 13,60 Deutschland 71,87

RESINA 2001-2018 Subtypes men, 80,1 % C other CRFs G D n.d. other 61 32 22 23 47 49 02_AG 125 A 236 B 2458

RESINA 2001-2018 Subtypes women 18.7% D n.d. G 35 5 37 other B 22 200 other CRFs 27 C 64 02_AG 114 A 172

RESINA 2001-2018 Transmission risks men pattern II bisexual blood transfusion IVDA other 4,21 0,87 0,29 5,08 0,39 unknown 9,64 heterosexual 13,88 MSM 65,65

RESINA 2001-2018 Transmission risks women blood transfusion other unknown 0,97 1,11 8,19 IVDA 9,86 heterosexual 45,42 pattern II 34,44

TDR 2001-2018 25 20 15 10 5 0 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 (86) (101) (124) (220) (218) (250) (358) (374) (290) (331) (261) (247) (239) (238) (166) (145) (157) (40) NRTI NNRTI PI INI any

RESINA 2001-2018 Summary  The RESINA study provides a diverse and representative study cohort  Non-B-subtypes are present in about 20% of men and 75% of women in our cohort  Detailed analyses regarding TDR, epidemiology and subgroups are planned  808 patients with therapy-naive and 433 patients with post- treatment integrase sequences are already included in the database

RESINA-Study Centers Praxis Arbter, Krefeld Praxis Mauruschat, Wuppertal Praxis Baumann, Neuss Praxis Mauss, Schmutz, Hegener, Düsseldorf Praxis Becker-Boost, Duisburg Praxis Miasnikov, Düsseldorf Praxis Busch, Christenen, Münster Krankenhaus der Augustinerinnen, M. Oette, Köln Praxis Carls, Huber, Düsseldorf Klinikum Osnabrück, A. Mutz Praxis Dresch, Köln Uniklinik Düsseldorf, B. Jensen, T. Feldt, D. Häussinger Uniklinik Essen, S. Esser Praxis Reith, Düsseldorf Uniklinik Köln, G. Fätkenheuer Klinik Kemperhof, A. Rieke, Koblenz Praxis Ferdinand, Köln Uniklinik Bonn, J. Rockstroh Praxis Gantke, Düsseldorf Praxis Schäfer, Bielefeld Praxis Gippert, Hartmann, Quaing, Münster Praxis Schoelzel, Troisdorf Praxis Grüneberg, Münster Praxis Scholten, Köln Praxis Radecki, Köln Krankenhaus Hagen, T. Scholten, Hagen Klinikum Dortmund, M. Hower, Dortmund Praxis Schons, Düsseldorf Praxis Isernhagen, Römer, Qurishi, Köln Praxis Schuster, Wuppertal Praxis Knechten, Habets, Aachen Praxis Stechel, Juretzko, Köln Praxis Köthemann, Neuwirth, Köln Praxis Strehlow, Petry, Düsseldorf Praxis Kwirant, Duisburg Praxis Wiesel, Theisen, Voigt, Köln

Gründungsteam Jasmina Bogojeska Francesca Incardona Rolf Kaiser Kasia Bozek Mattia Prosperi Daniel Hoffmann Florian Klein Joachim Büch Michal Rosen-Zvi Martin Däumer Jochen Selbig Glenn Lawyer Melanie Balduin Anders Sönnerborg Jürgen Klein Saleta Sierra Aragon Alejandro Pironti Maurizio Zazzi Eberhard Schrüfer Jens Verheyen Alexander Thielen Finja Schweitzer André Altmann Elena Knops Niko Beerenwinkel Weitere Kooperationspartner Susanna Trapp Francisco Domingues Eva Heger Ricardo Camacho Genafor e.V./ Kirsten Roomp Maria Neumann Fraune Francesca Ceccherini-Silberstein Jörg Rahnenführer HIV-Grade Claudia Müller Buonaventura Clotet Hiroto Saigo Eugen Schülter Thomas Berg Manon Eckhardt Michael Böhm Oliver Sander Richard Harrigan Patrick Braun Angelika Hergesell Tobias Sing Hans-Georg Kräusslich Gerd Fätkenheuer Dörte Hammerschmidt Matthias Döring Barbara Müller Klaus Korn Anna Marie Sikorski Jürgen Rockstroh Jean Claude Schmit Frank Wilhelm Barbara Schmidt Robert Shafer Klaus Remmel Hauke Walter Valentina Svicher Tobias Nolden Ibrahim Boussaad Benedikt Weissbricht Annemie Vandamme Dieter Häussinger Patrick Braun Martin Obermeier Mark Oette Stefan Esser Martin Stürmer Stefan Reuter Björn Jensen Falk Hüttig Jörg Timm André Fuchs Nadine Lübke Heinz-Ansmann-Stiftung Ulrike Haars Ralf Winzer Steffi Göbels Arne Kroidl Ruth Petch

Vielen Dank für die Aufmerksamkeit !