Bill & Melinda Gates Foundations Global Health Program Dr. - PowerPoint PPT Presentation

Bill & Melinda Gates Foundation’s Global Health Program Dr. Trevor Mundel President, Global Health Program

EVERY PERSON DESERVES THE CHANCE TO LIVE A HEALTHY, PRODUCTIVE LIFE.

Our Approach to Global Health Our Global Health program aims to harness advances Our Global Health program aims to harness advances in science and technology to save lives in developing countries. 3

MenAfriVac Delivery and Impact  Dramatic reduction in reported meningitis cases in “epidemic districts”  Disappearance of Group A meningitis  Stable fraction of non Group A meningococcal isolates  Absence of Group A in carriage studies 2010 ~ 20 Million vaccinated 2011 ~ 35 Million vaccinated 2012 ~ 55 Million to be vaccinated

Saving Lives Today Meningitis Epidemic Curve 1997-2011 (Burkina Faso data) 2007 2008 2006 2009 2011

Portfolio Matrix Portfolio Matrix PaMZ DS LIQ WC CP 116E Liquid Surgical Male PaMZ MDR Circumcision Novel-2 NRRV HPV Vx RTS,s 2 nd Gen REMox Pox Protein $1 DOLLARS PER DALY AVERTED RTS,s $10 NITD 609 GNF 156 OZ 439 Tafenoquine PCV (SII) Flubendazole $100 M72 M72 M72 Bed Nets Leish F3 Anti-Wolbachia Anti-Secretory $1K Aeras485 HIV/AIDS Aeras402 Dapivirine Ring Malaria Shigella CP $10K Hookworm TMC278LA TB Passive Pneumonia Immunizations 100 Million $100K DALYs EDD Averted NID $1M 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% PROBABILITY OF SUCCESS (PTRS)

Translational 10X 100% 100 M PROBABILITY OF SUCCESS (PTRS) 80% Cost 60% Reduced 40% Investment at Risk 20% 10 M 1 M

Leveraging Biotech Energy for Next-Generation Malaria Vaccine • Rapid (<2 wk) • Comprehensive • Unbiased plasmablast-based Ab evolution • Diversification profiling

EVERY PERSON DESERVES THE CHANCE TO LIVE A HEALTHY, PRODUCTIVE LIFE.