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!"#$%"$#&'()*+'+,-(.-(/01(&23("45( - PowerPoint PPT Presentation

Jun 12, 2023 •163 likes •540 views

Symposium Celebrating the 40th Anniversary of the Protein Data Bank, Cold Spring Harbor, NY, USA, October 29, 2011 !"#$%"$#&'()*+'+,-(.-(/01(&23("45( 6#+"5*2(7&"&()&28 ( 9$#"(:;"4#*%4(

  1. Symposium Celebrating the 40th Anniversary of the Protein Data Bank, Cold Spring Harbor, NY, USA, October 29, 2011 !"#$%"$#&'()*+'+,-(.-(/01(&23("45( 6#+"5*2(7&"&()&28 ( 9$#"(:;"4#*%4( (<45(!%#*==>(15>5&#%4(?2>@"$"5A(B&(C+''&A(DEA(F!E(&23(( G<H(I;#*%4A(I;#*%4A(!J*"K5#'&23(

  6. • C:\Dokumente und Einstellungen\All Users \Dokumente\Eigene Bilder\KW-dias \Yale_10.2005\reduced\Yale-07.jpg

  12. PSI:BIOLOGY

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  14. 3"2)2+25%@2"%#*)2.#),=%89:%;)"*+)*",%=,),"./0#120% 67%89:%;#.45,%4",4#"#120% <7%89:%;)"*+)*",%=,),"./0#120% L*%#+>%&'5A($2'&.5'53( =#+"5*2( E$"+L&"53(.&%8.+25(&>>*,2L52"( R7( R H(/01(>%#552*2,( ?2"5#&%@\5(\&'*3&@+2(+[(.&%8.+25(&>>*,2L52">( D45L](>4*^(&3&="&@+2("+(/_G!`(>=5%"#&( Z'+.$'&#([+'3( E$"+L&"53(V R HA R HXT/_G!`T.&>53(>*35%4&*2( &>>*,2L52"A(%+2>"#&*2"(%+''5%@+2(&23( >"#$%"$#5(%&'%$'&@+2( L*%#+>%&'5A(V$T RW /XT =#+"5*2( /01(>"#$%"$#5(>+'\53( U7(V RW /A R HXTH!YD( #++*"#),%>#+?>20,%@25=% 89:%4"2A5,% ?2"5#&%@\5(/01(>"#$%"$#5(#5Q25L52"( !"#$%"$#5TO$&'*"-( 82% =#+"5*2(>+'$@+2( /01(>"#$%"$#5(\&'*3&@+2( B,;% Ra(L,T>%&'5A(V$T Rb DA RW /XT /01(>"#$%"$#5("+(67)( =#+"5*2(

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  17. <7 (/01(>"#$%"$#5 ( /01(5f=5#*L52">( W%J3(BG89:%,P4,"/.,0); ( E$"+L&"53(.&%8.+25(&>>*,2L52"( UaTbW(U7T=#+g5%@+2>(5&%4( ?2"5#&%@\5(\&'*3&@+2(+[(.&%8.+25(&>>*,2L52">( D45L](>4*^(&3&="&@+2("+(/_G!`(>=5%"#&( W-% 6D 8G",;25X,=%C 6 &E 6 &FG8IO(B% E$"+L&"53(V R HA R HXT/_G!`T.&>53(>*35%4&*2( W-% 6W UG",;25X,=%C 6 &E 6 &FG8IO(BY#5/Z% &>>*,2L52"A(%+2>"#&*2"(%+''5%@+2(&23( W-% 6W UG",;25X,=%C 6 &E 6 &FG8IO(BY#"2 Z% >"#$%"$#5(%&'%$'&@+2( /01(>"#$%"$#5(>+'\53( #++*"#),%>#+?>20,%@25=% ?2"5#&%@\5(/01(>"#$%"$#5(#5Q25L52"( /01(>"#$%"$#5(#5Q253(

  18. PSI:BIOLOGY h"&'6#53S(&(J5.(>5#\5#([+#(=#53*%@+2(+[(=#+"5*2(%#->"&''*K&.*'*"-(( i4j=SkkP&>].$#24&L]+#,kh"&'6#53T%,*kf"&']='l(

  19. PSI:BIOLOGY !"#$%#0=%89:%[/K[5$%+2.45,.,0)#"$%% !'&.*2>8*(BA(C&#+>K5J>8*(BA(1+3#*,$5>(E6A(1-%4'5J>8*(BA(:*'>+2(?EA(B5>'5-(!EA(Z+3K*8(E]( \'[,%+[#55,0K,%2@% 4"2),/0%;)"*+)*",%=,),"./0#120G%5,;;20;%@"2.%;)"*+)*"#5%K,02./+;E\ ( !"#$%&'()*&%'*%+ (RdS(UcmUTUcnU( iUaaml](

  20. `U(a%89:%'#"K,)%(,5,+120%20%)[,%&'GU"$;)#552K"#4[$%b#+?K"2*0= ( ]0/X,";,%2@%4"2),/0%% 3@#.E%2)[,"; ( (,L*,0+,;%Y^R_6T R Z ( 3@#.E%;25X,= (( 3@#.E%+"$;)#5%;)"*+)*",%=,),"./0#120%02)%;*++,;;@*5 ( 3225%@2"%89:%)#"K,); (

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  22. NP_247299.1 ( Methanococcus jannaschii ) NMR NMR/Crystal

  23. Backbone Dihedral Angles � and �

  24. NP_247299.1: cis / trans isomers of N103– P104 NMR chemical shifts: two conformations for 64–66 and 101–104

  26. NP_247299.1: segments 64–66 and 101–104 trans -P104 cis -P104

  28. PSI:BIOLOGY b2*0=%i/K#0=;%J/=%/0%f*0+120#5%J002)#120%2@% Proteins % OP#.45,;%2@%*0?02c0%5/K#0=;% ((o((((0$%4(3*\5#>*"-(+[('*,&23>(*>([+$23(*2(=#+"5*2(%#->"&'(( >2*0=%)2%`U(a%;)"*+)*",;% (>"#$%"$#5>(+[("45(CD!Z(&23(+"45#(6!?(%52"5#>]( ((o( (?2"5#5>@2,(#+'5([+#(/01(*2(>+'$@+2S(( (((((((((oo((<45(*352@"-(+[("45(.+$23('*,&23(*>(+^52(3*p%$'"("+(((( ((((((((%+2Q#L(.-(hT#&-(%#->"&''+,#&=4-(&'+25]( (((((((((oo((!%&#%*"-(+[(E=+T=#+"5*2(%#->"&'(>"#$%"$#5>]( (( '$4,;%2@%>2*0=%5/K#0=;%/=,01A,=%/0%3(H%;)"*+)*",;% Others lRDm%2@%4"2),/0;%[#X,%>2*0=%5/K#0=;%

  29. PSI:BIOLOGY J<i-6%Y !"#$%"#&"'"# Z% 89:% 89:eU"$;)#5%

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  31. PSI:BIOLOGY J<i-6% C 6D 8E 6 &FG&(oU%i/0,;[#4,;%

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  33. Prion Proteins 1996 �

  34. PSI:BIOLOGY

  35. � <G � <%5224%/0%X#"/#0);%2@%.3"3Y6<6v<W6Z%

  36. mPrP[Y225A,Y226A](121–231) T � o ( 1 H)

  37. .3"3% 92=,5;u%.3"3CB6RkJ%%%%%%%%B%F% � 6 %w%VRT% � 6 %w%GRT% :6RQ% :6RQ% o6RS% :6RQ% o6RS% � 6% � 6% o6RS% � 6% � <% B6Rk% f6gD% � <% f6gD% � <% f6gD% (6gT% B6Rk% (6gT% B6Rk% � <% 86g6% 86g6% � <% 86g6% � <%

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