W.M. KECK FOUNDATION [Funding for High-Risk, High-Reward Science] October 19, 2017 Watt Family Innovation Center October 2017 1
Keck Foundation: Funding for High-Risk, High-Reward Science INTRODUCTION TO ORD AND CFR CORPORATE AND FOUNDATION RELATIONS (CFR) OFFICE OF RESEARCH DEVELOPMENT (ORD) Development and Alumni Relations Division Research Division SEZ ATAMTURKTUR JANE JACOBI KELLY MCSWAIN ANN MARIE ALEXANDER AMBER PADGETT Assistant Vice President of Team Leader, Offjce of Program Manager, Offjce of Sr. Director of Corporate and Development Coordinator - Research; Director, Offjce of Research Development Research Development Foundation Relations Corporate and Foundation Research Development Relations E: sez@clemson.edu E: jacobij@clemson.edu E: kmcswai@clemson.edu E: amalex@clemson.edu E: day6@clemson.edu P: 864-656-3003 P: 864-656-1296 P: 864-656-0260 P: 864-656-7013 P: 864-656-2247 2
Keck Foundation: Funding for High-Risk, High-Reward Science OVERVIEW OF THE W.M. KECK FOUNDATION The W.M. Keck Foundation was established in 1954 in Los Angeles by William Myron Keck, founder of The Superior Oil Company. The Keck Foundation is one of the nation’s largest philanthropic organizations, with assets of more than $1 billion. Mr. Keck envisioned a philanthropic institution that would provide far-reaching benefjts for humanity. By taking a bold, creative approach to grantmaking, he created a legacy the Foundation upholds today. The Foundation focuses its grantmaking on Science and Engineering Research, Medical Research, Undergraduate Education, and Southern California. Each of Keck’s grant programs invests in people and programs that are making a difference in the quality of life, now and in the future. 3
Keck Foundation: Funding for High-Risk, High-Reward Science RESEARCH GRANT PROGRAM Keck’s Research Program seeks to benefjt humanity by supporting projects in two specifjc areas: 1. Medical Research 2. Science and Engineering Research Research Program awards range from $500K to $5M, but most are between $1M and $2M. Projects must: • Be distinctive and novel in their approach, question the prevailing paradigm , or have the potential to break open new territory in their fjeld; • Be innovative and interdisciplinary and focus on important and emerging areas of research; • Demonstrate a high level of risk due to unconventional approaches; • Have the potential for transformative impact , such as the founding of a new fjeld of research, the enabling of observations not previously possible, or the altered perception of a previously intractable problem; • Not focus on clinical or translational research , treatment trials, or research for the sole purpose of drug development; and • Fall outside the mission of public funding agencies. 4
Keck Foundation: Funding for High-Risk, High-Reward Science KECK RESEARCH GRANT PROCESS Keck’s research program has a three-step application process. 1. Concept Paper Submission/Consultation with Keck Program Offjcer • Faculty teams should submit one-page concept papers describing their proposed research project. Up to 8 concept papers can be submitted to the Keck Foundation (4 in Science & Engineering, 4 in Medical Research) per institution. • Each institution’s Development offjce submits the selected concept papers to Keck and schedules one conference call with a program offjcer to discuss all submitted papers. PIs do not participate in this call. • *NOTE: Amber Padgett is Clemson’s offjcial institutional liaison to the Keck Foundation. Per their requirements, only the institutional liaison can communicate with the Foundation on behalf of Clemson. • The program offjcer will provide feedback on concept papers submitted and advise whether or not the proposals should move forward to the Phase I application. Only one proposal from the Science & Engineering Research area and one proposal from the Medical Research area can be submitted by Clemson University in Phase I. 2. Phase I Application • The Phase I application consists of a project summary (1 page), project description (2 pages), a project budget, and various institutional forms. One project leader must be defjned in the application. • The Foundation will notify those applicants who are invited to submit a full proposal 10 weeks after the Phase I applications are due. 3. Phase II/Full Proposal • Phase II proposals are by invitation only and must be submitted in hard copy form one month after the invitation date. If a full proposal is invited, site visits or conference calls are conducted at the discretion of the Foundation. 5
Keck Foundation: Funding for High-Risk, High-Reward Science KECK RESEARCH GRANT TIMELINE Keck’s research program has two grant cycles annually. The application cycle being discussed today is the December cycle (awards made in December 2018). Clemson’s internal timeline and deadlines are included on slide 13. Pre-Application Phase I Application Notifjcation of Invitation Full Proposal Submission Counseling Deadline to Submit Full Proposal Deadline January 1 - February 15 May 1 July 15 August 15 6
Keck Foundation: Funding for High-Risk, High-Reward Science WHAT DOES HIGH-RISK RESEARCH LOOK LIKE? KECK SCIENCE & ENGINEERING RESEARCH AWARDS - 2017 Cornell University | $1,000,000 Team: Darrell G. Schlom (Professor), J.C. Seamus Davis (Professor), Craig J. Fennie (Professor), Eun-Ah Kim (Assoc. Professor), Kyle M. Shen (Asst. Professor) Summary: Researchers at Cornell University will develop an odd-parity topological superconductor (OPTSC) material that will lay the practical foundation for a stable and scalable quantum computing (QC) technology. Temple University | $1,200,000 Team: C. Jeff Martoff (Professor), Eric Hudson (Assoc. Professor - Penn State), Andrew Renshaw (Asst. Professor - Univ. of Houston), Peter F. Smith, Hanguo Wang (Adjunct Professor - UCLA), Paul Hamilton (Asst. Professor - UCLA) Summary: A team of researchers from Temple University, the University of California, Los Angeles, and the University of Houston plan a laboratory-scale experimental search for a new “sterile” type of neutrino. Stony Brook University | $1,000,000 Team: Lilianne R. Mujica-Parodi (Assoc. Professor), Ken Dill (Professor), Steven Skiena (Professor), Steven Stuffmebeam (Assoc. Professor - Harvard), Jacob Hooker (Assoc. Professor - Harvard) Summary: In moving towards the goal of personalized medicine, investigators at Stony Brook University in collaboration with researchers at Massachusetts General Hospital/Harvard Medical School approach brain network connectivity, assessed by functional magnetic resonance imaging (fMRI) and associated cognitive function, as a dynamic emergent phenomenon. 7
Keck Foundation: Funding for High-Risk, High-Reward Science WHAT DOES HIGH-RISK RESEARCH LOOK LIKE? KECK MEDICAL RESEARCH AWARDS - 2017 Fred Hutchinson Cancer Research Center | $1,000,000 Team: Cyrus Ghajar, Peter Nelson, Patrick Paddison, Slobodan Beronja, Stephen Tapscott, Kirk Hansen (Assoc. Professor - University of Colorado) Summary: Using skeletal muscle (SkM) as a model of infertile soil, a team of investigators at the Fred Hutchinson Cancer Research Center and at the University of Colorado, Denver proposes a series of experiments at the biological and technological cutting edge to specify the molecular mechanisms by which SkM suppresses metastasis. Mayo Clinic | $1,200,000 Team: Jan van Deursen, Darren Baker, Atta Behfar, Hu Li, Andre Terzic Summary: A multidisciplinary team of Mayo Clinic investigators discovered that, in adult mice, senescent cells accumulate in the pericardium with aging and that the systemic elimination of senescent cells from midlife on attenuates fundamental aspects of car- diac aging, including cardiomyocyte hypertrophy, loss of stress tolerance and diastolic dysfunction, all of which are linked to heart failure. Sanford Burnham Prebys Medical Discovery Insitute | $1,000,000 Team: Duc Dong, Clyde Campbell, Joseph Lancman, Sean Zeng Summary: To bypass obstacles related to the use of in vitro cells for regenerative medicine, Sanford Burnham Prebys investigators plan to generate replacement cells by directly converting any cell of choice, while they remain in the body (in vivo). 8
Keck Foundation: Funding for High-Risk, High-Reward Science WHAT DOES HIGH-RISK RESEARCH LOOK LIKE? “Popular” topics for Keck over the past four years: • Physics and astrophysics • Geophysics • Marine ecosystems • DNA sequencing • Materials science • Planetary science • Cancer • Neuroscience • Computing • Atomic science • Regenerative tissue • Cognitive science • Quantum information • Paleontology • Genomics • Biosensors Average team size: Ranges from 2–6, but average seems to be 4–5 Seniority of team: Also ranges; most proposals have at least one full professor as a team member. 9
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