Science and Government The Royal Society 9 July 2014 Professor - PowerPoint PPT Presentation

Science and Government The Royal Society 9 July 2014 Professor Dame Sally C. Davies FRS FMedSci Chief Medical Officer & Chief Scientific Adviser

• The role of scientists • Introducing evidence into policy

• The role of scientists • Introducing evidence into policy

Clinical research and the NHS 1988 House of Lords report 1998 Culyer Declaration 2005 Review of R&D budget barriers to research in the NHS

Barriers to clinical research • Infrastructure • Training (fewer clinical academics) • Research funding (historical, low) • Governance • Lack of incentives

Drivers for change • Evidence based medicine • Technology / infrastructure platforms • Reducing bureaucracy

Why is the Government committed to Research in the NHS? • improve health outcomes through advances in research • improve quality of care by NHS Health and Wealth participation in the research process • strengthen International competitive position in science • drive economic growth through investment by life science industries

NIHR Health Research System Faculty Investigators & Associates Senior Trainees Investigators Universities Infrastructure Research NHS Trusts Clinical Research Research Projects Networks & Programmes Patients & Public Clinical Research Research Schools Facilities, Centres & Units Research Research Information Management Systems Systems Systems

The NIHR Network portfolio: supporting Industry At the end of 2013/14, the Network was supporting 733 recruiting commercial contract studies – the highest number since records began in 2008/09

NIHR BRCs / BRUs leveraged funding

Recruitment and retention Clinical academic careers 4,000 NIHR Established 3,500 3,000 2,500 FTE 2,000 1,500 1,000 500 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Professor Reader/ Senior Lecturer Lecturer Grand Total Source: Medical Schools Council survey of staffing levels of medical Clinical Academics in UK medical schools (31 July 2013)

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Major NIHR infrastructure platforms • NIHR BioResource • NIHR Translational Research Collaborations – Dementia – Rare diseases • Translational Research Partnerships – Inflammatory Respiratory Diseases – Joint and Related Inflammatory Diseases • Genomics England: 100,000 whole genomes • UK BioBank • BioSample Repository • MRC–NIHR Phenome Centre • The Francis Crick Institute

Major NIHR infrastructure platforms • NIHR BioResource • NIHR Translational Research Collaborations – Dementia – Rare diseases • Translational Research Partnerships – Inflammatory Respiratory Diseases – Joint and Related Inflammatory Diseases • Genomics England : 100,000 whole genomes • UK BioBank • BioSample Repository • MRC–NIHR Phenome Centre • The Francis Crick Institute

• The role of scientists • Introducing evidence into policy

Annual Report of the Chief Medical Officer • Independent • Surveillance • Advocacy

Annual reports 2011/2012

Surveillance 2011

Surveillance 2012

Infections and AMR Drug Resistant E. Coli (30% mortality ) Klebsiella 7.8% E. Coli 36%

AMR - a cross government priority WHA resolution • agenda item G7 science ministers and • Carnegie Group WISH forum • 5 year UK strategy • Longitude prize topic • Independent commission of R&D pipeline •

Science and Government The Royal Society 9 July 2014 Professor Dame Sally C. Davies FRS FMedSci Chief Medical Officer & Chief Scientific Adviser

The NIHR network portfolio The Network has more than doubled the number of recruiting studies since records began in 2008/09 – from 1,681 in 2008/09 to 4,107 in 2013/14