School of Chemistry & Biochemistry SCHOOL MEETING JULY 30 2012 - PowerPoint PPT Presentation

FACULTY OF LIFE AND PHYSICAL SCIENCES School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 AGENDA 1. Summary of the School’s position 2. Figures on enrolments & load 2. PhD completion scholarships; School policy 3. Update on other School matters: Some congratulations; UWA Open Day; WiFi in Bayliss Building; printers/photocopiers; research group servers !

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Summary of the School’s position A School Op--Income to Salary Expenditure Results-2012 -6 Months (Budget vs Actual) and 12 Months Projection (by Faculty) $8 M 120.00% $7 M 100.00% $6 M % Income to Salary Expenditure 80.00% $5 M $4 M 60.00% $3 M 40.00% $2 M 20.00% $1 M $0 M 0.00% YTD Actual CY YTD Budget CY Budget 12 Months CY Income 3.7 3.5 6.4 Salary Expenditure 3.1 3.1 6.9 % Income to Salary Expenditure 84% 89% 108% The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Summary of the School’s position The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Summary of the School’s position The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Summary of the School’s position The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Summary of the School’s position The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 Some comments on student load From 9 February: • 738 EFTSL • Of these 738 EFTSL, 453 are domestic, 229 international offshore (PSB Singapore), 55 international onshore. There are ~31 PG students in chemistry, ~50 in biochemistry/molecular biology/genetics. From 29 July: • 830 EFTSL • Of these 830 EFTSL, 516 are domestic, 230 international offshore (PSB Singapore), 84 international onshore. There are ~38 PG students in chemistry, ~50 in biochemistry/molecular biology/genetics The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – FEBRUARY 27 2012 Some enrolment numbers at 24 February cf. 30 July Semester 1 Semester 2 BIOC2201 249 --> 242 BIOC2202 184 --> 183 total = 451 --> 517 CHEM1001 389 --> 407 CHEM1001 62 --> 110 total = 485 --> 553 CHEM1002 228 --> 242 CHEM1002 257 --> 311 CHEM1003 350 --> 326 CHEM1004 736 --> 726 CHEM2001 126 --> 131 CHEM2002 76 --> 89 GENE2204 173 --> 178 CHEM2003 89 --> 74 SCIE2225 116 --> 120 GENE2230 87 --> 91 SCIE1106 798 --> 760 How does level 1 load compare? CHEM1XXX + SCIE1106/3: 302.5 EFTSL in 2011 297.0 EFTSL in 2012 - down 1.8% The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 PhD completion scholarships PhD Completion Scholarships are designed, and supported by The University of Western Australia's central research allocation funding, to encourage timely PhD completions. This is a reimbursement scheme, whereby payments for a living allowance are made in the first instance from school/faculty accounts. The full amount paid is reimbursed from central funds if the recipient submits their thesis within the stipulated time. If the thesis is not submitted by the due date, there is no reimbursement from central scholarship funds . As funds are limited, PhD Completion Scholarships are not to be viewed as a second extension of a current scholarship. All other things being equal, priority is given to nominated students who have not previously, or recently, received scholarship support. Payment type Fortnightly Stipend Value $27,228 pa • Please note these scholarships are PhD Candidates only and International applicants have to provide proof that their tuition fees will be covered. These scholarships do not cover tuition fees. Four Rounds per year: • 1st February, close 28th February - for awards starting March/April/May • 1st May close 31st May - for awards starting June/July/August • 1st August close 31st August - awards starting September/October/November • 1st November close 30th Nov - awards starting December/January/February The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 PhD completion scholarships - School policy If the student does not complete on time the School will incur the total cost of the Scholarship. It is the supervisor’s responsibility to ensure that students submit their thesis on time. When a student has defaulted on the terms of the Completion Scholarship the supervisor will be liable for 50% of the total cost. To help supervisors keep to the Scholarship deadline a School Admin Officer will contact staff with a reminder one month prior to the nominated completion date. The University of Western Australia

School of Chemistry & Biochemistry SCHOOL MEETING – JULY 30 2012 ARTICLE Multimodal Analysis of PEI-Mediated Other School matters Endocytosis of Nanoparticles in Neural • Congratulations: Cells Cameron Evans Cameron W. Evans, †,‡ Melinda Fitzgerald, ‡ Tristan D. Clemons, †,‡ Michael J. House, § Benjamin S. Padman, ^ Jeremy A. Shaw, ^ Martin Saunders, ^ Alan R. Harvey, Bogdan Zdyrko, # Igor Luzinov, # Gabriel A. Silva, 4 , 3 Winner of 2012 GRS Prize for ) Sarah A. Dunlop, ‡ and K. Swaminathan Iyer †, * Research Achievement † School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia, ‡ Experimental (Biological Sciences) and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Australia, § School of Physics, The University of Western Australia, ) Australia, ^ Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Australia, School of Anatomy and Human Biology, The University of Western Australia, Australia, # School of Materials Science and Engineering, Clemson University, Clemson, South Carolina 29634, United States, An ¡award ¡ceremony ¡and ¡lunch ¡will ¡ 4 Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States, and 3 Department of Ophthalmology, University of California, San Diego, Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, California 92037, United States be ¡held ¡in ¡the ¡Banquet ¡Hall ¡of ¡the ¡ he use of nanoparticles for site- T University ¡Club ¡on ¡the ¡2nd ¡of ¡August ¡ ABSTRACT speci fi c delivery of therapeutic pay- loads is a goal that has attracted 2012 considerable attention in biomedical research. 1,2 The potential ability to load a single nanoparticle preparation with a vari- ety of drugs and facilitate delivery to speci fi c intracellular or extracellular sites ACS Nano 5 , 8640 (2011) would be a signi fi cant advance, because the nanoparticle delivery strategy is gener- (IF = 11.4) alizable and can be used to release low Polymer nanoparticles are widely used as a highly generalizable tool to entrap a range of di ff erent molecular mass compounds, proteins, and drugs for controlled or site-speci fi crelease. However, despite numerous studies examining the kinetics recombinant DNAs at focal areas of disease, of controlled release, the biological behavior of such nanoparticles remains poorly understood, maximizing clinical bene fi ts while limiting side e ff ects. 2,3 Recent reports also suggest particularlywithrespecttoendocytosisandintracellulartra ffi cking.Wesynthesizedpolyethylenimine- that nanoparticles can in fl uence cellular decorated polymer nanospheres ( ca. 100 � 250 nm) of the type commonly used for drug release and signaling by interacting with membrane used correlated electron microscopy, fl uorescence spectroscopy and microscopy, and relaxometry to microdomains that house di ff erent signal- trackendocytosisinneuralcells.Thesecapabilitiesprovideinsightintohowpolyethyleniminemediates ing components such as receptors, signal the entry of nanoparticles into neural cells and show that polymer nanosphere uptake involves three activators, and transducers. 2,4 � 6 Because distinct steps, namely, plasma membrane attachment, fl uid-phase as well as clathrin- and caveolin- the response to this activation includes independent endocytosis, and progressive accumulation in membrane-bound intracellular vesicles. changes to cellular transport and target- These fi ndings provide detailed insight into how the intracellular delivery of nanoparticles is mediated ing, a precise understanding of the entire intracellular nanoparticle itinerary, beyond by polyethylenimine, which is presently the most commonly used nonviral gene transfer agent. This the point of initial entry, is important to fundamental knowledge may also assist in the preparation of next-generation nonviral vectors. fully realize the potential of these nano- The University of Western Australia KEYWORDS: nanosphere . endocytosis . neuron . polyethylenimine . materials as drug carriers and transfection multimodal imaging agents.