Recent advances in gastrointestinal Mapping and Modelling Tim Angeli, PhD Auckland Bioengineering Institute University of Auckland, New Zealand
Slow Waves and Gastric Contractions
Previous Slow Wave Studies
High-Resolution (HR) Electrical Mapping Du et al, Ann Biomed Eng 2009; 37:839-46 O‘Grady et al, Am J Physiol Gastrointest Liver Physiol 2010; 299:G585-92
GEMS Software Package Yassi et al, BMC Gastroenterol 2012;12:60. Paskaranandavadivel et al, IEEE Trans Biomed Eng 2012; 59:882-89.
Recent Mapping Cohort 1) Healthy Controls • n = 21 patients • Devoid of gastric pathology 2) Gastroparesis • n = 12 patients • Diagnosed with medically refractory gastroparesis 3) Chronic Unexplained Nausea and Vomiting (CUNV) • n = 8 patients • Diagnosed with CUNV Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98. O‘Grady et al, Am J Physiol 2010; 299:G585-92.
Healthy Control: Normal Activity Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.
Gastroparesis Abnormal Initiation: Unstable O‘Grady et al, Gastroenterology 2012; 143:589-98.
CUNV Abnormal Initiation: Stable Angeli et al, Gastroenterology 2015; 149:56-66.e5.
Updated Dysrhythmia Classification Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.
Multi-Scale Mathematical Modelling Multiscale Mathematical Model Du et al. WIREs Syst Biol Med 2013;5:481-93.
Multi-Scale Mathematical Modelling Du et al. WIREs Syst Biol Med 2013;5:481-93.
Tissue-Level Slow Wave Propagation Wild Type Knockout Du et al. Biophys J 2010;98(9):1772-81.
Organ-Level Slow Wave Propagation Du et al. Biophys J 2010;99(9):2784-92.
Body-Surface Slow Wave Potentials Du et al. Biophys J 2010;99(9):2784-92.
Dysrhythmia in Gastroparesis
Conclusions • High-resolution mapping and multi-scale modelling have provided improved insights into gastrointestinal regulation, function, and health. • Engineering principles can be highly valuable in improving our understanding of the processes and mechanisms of digestion. • These data and methods may provide an enhanced basis for the research and development of functionally-targeted food and nutrition.
Horizons: Diagnostics Bedside Tests Endoscopic Diagnosis Clinical Translation
Horizons: Therapy Ablation Pacing model experimental
Horizons: Functional Nutrition Brit. J. Anaesth. 2000; 84(3):367-71. Dig. Dis. Sci. 2005; 50(10):1889-97. Am. J. Physiol. Gastrointest. Liver Physiol. 2003; 284:G481-9.
Team A/Prof Leo Dr Peng Du Dr Greg O’Grady Prof John Windsor Cheng Dr Tim Angeli Dr Niranchan Paskaranandavadivel Funding
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