proteostasis
play

PROTEOSTASIS European network to integrate research on intracellular - PowerPoint PPT Presentation

Sep 29, 2023 •657 likes •1.13k views

PROTEOSTASIS European network to integrate research on intracellular proteolysis pathways in health and disease COST ACTION BM1307 Duration: 25 th April 2014 until 24 th April 2018 PROTEOSTASIS The need to establish a Network PROTEOSTASIS

  1. PROTEOSTASIS European network to integrate research on intracellular proteolysis pathways in health and disease COST ACTION BM1307 Duration: 25 th April 2014 until 24 th April 2018

  2. PROTEOSTASIS The need to establish a Network

  3. PROTEOSTASIS Different disciplines with common interest Proteasome Neurodegeneration Transcription Ubiquitin Apoptosis Lysosomes Autophagy Ubiquitin- likes Signalling Structure Immune Cancer Proliferation

  4. PROTEOSTASIS COST, an opportunity for integration Proteasome Neural Transcription Ubiquitin degeneration Autophagy Apoptosis Ubiquitin- Lysosomes likes Cancer Immune Signalling Proliferation Structure Different fields of research but common questions

  5. PROTEOSTASIS Objectives INTEGRATION To defragment the field and increase communication. TRANSLATIONALITY To facilitate the transfer from basic to translational science. TECHNOLOGY To foster technology and knowledge in protein homeostasis. TRAINING To create and consolidate training efforts in the field.

  6. PROTEOSTASIS Initiators and collaborators Rosa Barrio Manuel S. Rodriguez Michael Glickman Olivier Coux Marc Piechaczyk Dimitris Xirodimas

  7. PROTEOSTASIS Participants

  8. PROTEOSTASIS Participant Countries Participant Countries: 17 COST FI SE DK IE UK NL PL DE AT FR SI PT IT ES TR EL IL Participant Groups: 80 November 2013

  9. PROTEOSTASIS Participant Countries Participant Countries: 27 + Ukraine + USA+ Republic of Korea IS US FI NO SE EE DK IE UK NL PL BE DE CZ UA AT FR CH HU SI RO HR RS PT IT ES TR EL KR IL Participant Groups: 274 February 2018

  10. PROTEOSTASIS Gender Distribution All Members Management Committee Core Group Female Females Males s Males Number % Number % Number % Males 28 56,00 Males 176 64,23 Males 12 54,55 Females 22 44,00 Females 98 35,77 Females 10 45,45 Total 274 100 Total 50 100 Total 21 100

  11. PROTEOSTASIS Participant Countries Country distribution Inclusiveness Target Countries KR CZ PL PT RO HR USA AT BE DK EE RS SI FI TR SE CH UK FR ES DE Non-ITC PT IL NL IT SI GR RS IS IE RO PL HU Participant Groups: 274 February 2018

  12. PROTEOSTASIS Activities

  13. Overview of Activities PROTEOSTASIS (June 2014 – April 2018) Autumn Spring 1st MC Meet 25/04 June July August September October November December January February March April May 2014-2015 18 TS: Ub&UbL, DM: Autoph TS: Aging, DM: EMBO W: Neuroacan MC,WG,W: 1st DM: Aging DM: SFBBM MC, WG: 1st W&B Plan IT, 06 Sept FR, 15 Sept GR, 22 Sept Arg, 19 Oct IT, 30 Oct PROTEOSTASIS IL, 15 Feb Sète, 28 May Virtual? STSMs S Polo D Lindholm N Chondrogianni MS Rodriguez L De Franceschi T Hoppe O Coux ES, 05 Nov R Farràs June July August September October November December January February March April May 2015-2016 2nd W&B Plan 13 DM: Cancer DM: Hormon TS: Yeast MC, WG, W: 2nd W: IMYA TS: Ub&UbL, W: Proteasomes UK, 5 July GR, 12 July FR, 7 Sept PROTEOST/EMBO PT, 29 Sept DE, 05 Oct FR, 6 April STSMs S Polo R Barrio S Leon HR, 18-22 Sept P Ludovico K Husnjak D Taillandier I Dikic June July August September October November December January February March April May 2016-2017 3rd W&B Plan 8 STSMs TS: Ub&UbL TS: Redox W: ECDO W: Plant MC, WG, W: 3rd W: ZOMES IT, 17 Sept GR, 19 Sept ES, 28 Sept ES, 27 Sept PROTEOSTASIS IT, 14 Feb D Komander N Chondrogianni C Muñoz ML Lois G Serino PT, 2 Nov R Matthiesen 2017-2018 8 STSMs June July August September October November December January February March April 4th W&B Plan W: EMBO W: W: MC, WG, W: N-ter TS: TS: Ub DM: Aging end of the HR, 15 Proteas. MVB Final: DE, Ag Proteostasis IT, 22 Sept GR, 16 Oct Sept IL, 12 Feb PT, 16 Feb N. GR, 22 Feb project FR, Sept S.Polo O Coux Dissmeyer F. Melchior E. Gur H. Girao E. Skoulakis S. Leon

  14. 96569 96569 96569 PROTEOSTASIS Summary Short Term Scientific Missions UA http://costproteostasis.eu/stsm-summary/ Carina 47 Number STSMs: Holmberg-Still

  15. PROTEOSTASIS Meetings & Workshops Symposium on 1 st PROTEOSTASIS Workshop, 2 nd MC 1 st Period Neuroacanthocytosis Rosa Farràs L de Franceschi Spain Italy 05-07 Nov 30 Oct – 1Nov 2014 2014 2 nd PROTEOSTASIS Workshop, 3 rd MC Proteasomes & Autophagy International Meeting on 2 nd Period Yeast Apoptosis Ivan Dikic Croatia 18-22 Sept Daniel Taillandier Paula Ludovico 2015 Portugal Sept 2015 France April 2016 3 rd PROTEOSTASIS Workshop, 4 th MC Euroconference on Zomes IX: PCI & Ubiq Plant Proteostasis 3 rd Period Apoptosis R Matthiesen Petek Balar Portugal Maria Lois Giovanna Serino Cristina Muñoz 2-5 Nov 2016 Spain Sept 2016 Spain Sept 2016 Italy Feb 2017 Proteostasis 4 th PROTEOSTASIS Workshop, 5 th MC Proteasome hub Vesicular Biology Ubiquitin & SUMO 4 nd Period via N-term M Skoulakis Greece Silke Meiners 22-24 Feb Henrique Girao Frauke Melchior Nico Dissmeyer Eyal Gur 2018 Portugal Feb 2018 Croatia Sept 2017 Germany Sep 2017 Germany Feb 2018

  16. PROTEOSTASIS Meetings & Workshops Symposium on 1 st PROTEOSTASIS Workshop, 2 nd MC 1 st Period Neuroacanthocytosis Rosa Farràs L de Franceschi Spain Italy 05-07 Nov 30 Oct – 1Nov 2014 2014 2 nd PROTEOSTASIS Workshop, 3 rd MC Proteasomes & Autophagy International Meeting on 2 nd Period Yeast Apoptosis Ivan Dikic Croatia 14 Number of Meetings Organised 18-22 Sept Daniel Taillandier Paula Ludovico 2015 262 * Portugal Sept 2015 France April 2016 Number of participants reimbursed: 3 rd PROTEOSTASIS Workshop, 4 th MC Euroconference on Zomes IX: PCI & Ubiq Plant Proteostasis 3 rd Period Apoptosis R Matthiesen Petek Balar Portugal Maria Lois Giovanna Serino Cristina Muñoz 2-5 Nov 2016 Spain Sept 2016 Spain Sept 2016 Italy Feb 2017 Proteostasis 4 th PROTEOSTASIS Workshop, 5 th MC Proteasome hub Vesicular Biology Ubiquitin & SUMO 4 nd Period via N-term M Skoulakis Greece Silke Meiners 22-24 Feb Henrique Girao Frauke Melchior Nico Dissmeyer Eyal Gur 2018 Portugal Feb 2018 Croatia Sept 2017 Germany Sep 2017 Germany Feb 2018

  17. PROTEOSTASIS Dissemination Meetings Nordic, Spanish & French Autophagy Networks EMBO Ubiquitin & Ubiquitin-likes Dan Lindholm Argentina France October September 1 st Period 2014 Manuel S Rodriguez 2014 EMBO Regulation of aging and proteostasis EMBO Regulation of aging and proteostasis Olivier Coux Israel France February February 2015 Thorsten Hoppe 2015 International Insect Hormone Workshop Beatson International Cancer Conference 2 nd Period Rosa Barrio Simona Polo Greece UK July July 2015 2015 IUBMB Meeting on Aging and Longevity 4 nd Period Olivier Coux Greece October 2017

  18. PROTEOSTASIS Dissemination Meetings Nordic, Spanish & French Autophagy Networks EMBO Ubiquitin & Ubiquitin-likes Dan Lindholm Argentina France October September 1 st Period 2014 Manuel S Rodriguez 2014 EMBO Regulation of aging and proteostasis EMBO Regulation of aging and proteostasis Olivier Coux Israel France February 18 February Number of Dissemination Meetings: 2015 Thorsten Hoppe 2015 5 Number of participants to be reimbursed: International Insect Hormone Workshop Beatson International Cancer Conference 2 nd Period Rosa Barrio Simona Polo Greece UK July July 2015 2015 IUBMB Meeting on Aging and Longevity 4 nd Period Olivier Coux Greece October 2017

  19. PROTEOSTASIS Training Schools EMBO Ubiquitin and related modifiers SFRR Biochemical Basis of Healthy Ageing 1 st Period Niki Chondrogianni Simona Polo Greece Italy September September 2014 2014 Practical on ubiquitin and ubiquitin-like proteins Ubiquitylation and sumoylation in yeast 2 nd Period Sebastien Leon Koraljka Husnjak France Germany September October 2015 2015 FEBS/SFRR: Redox Regulation of Metabolic Processes EMBO New approaches to study Ub and UbL mod 3 rd Period David Komander Greece Italy September September 2016 Niki Chondrogianni 2016 In vivo analysis of ubiquitylation and sumoylation Ubiquitin-assisted autophagy 4 nd Period Gwenael Rabut Simona Polo Italy France October September 2017 2017

  20. PROTEOSTASIS Training Schools EMBO Ubiquitin and related modifiers SFRR Biochemical Basis of Healthy Ageing 1 st Period Niki Chondrogianni Simona Polo Greece Italy September September 2014 2014 Practical on ubiquitin and ubiquitin-like proteins Ubiquitylation and sumoylation in yeast 2 nd Period Sebastien Leon Koraljka Husnjak France Germany September October 8 2015 2015 Number of Training Schools Organised 86 Number of People reimbursed: FEBS/SFRR: Redox Regulation of Metabolic Processes EMBO New approaches to study Ub and UbL mod 3 rd Period David Komander Greece Italy September September 2016 Niki Chondrogianni 2016 In vivo analysis of ubiquitylation and sumoylation Ubiquitin-assisted autophagy 4 nd Period Gwenael Rabut Simona Polo Italy France October September 2017 2017

  21. PROTEOSTASIS Participants in Activities (426) Gender balance MC/CG Member ECI Yes Females No Yes Males 39% No 53% 46% 54% 47% 61% ESR Number % MC/CG Number % Gender Number % Yes 165 38,73 Males 202 47,42 Yes 232 54,46 No 261 61,27 Females 224 52,58 No 194 45,54 Total 426 100,00 Total 426 100,00 Total 426 100,00

More recommend