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Maximizing Poultry health and productivity Nutritionist perspective Public demand to recude AB in animal feed Table 1: Ban of Antibiotic Growth Promotors in feed 1986 1997 1999 2003 2006 Ban of Batritacin, EU: complete ban EU: Ban of of


  1. Maximizing Poultry health and productivity Nutritionist perspective

  2. Public demand to recude AB in animal feed Table 1: Ban of Antibiotic Growth Promotors in feed 1986 1997 1999 2003 2006 Ban of Batritacin, EU: complete ban EU: Ban of of AGP Sweden Siramycin, Tylosin, EU: Nifursol Avoparcin (Flavo/Avilamycin) Virginiamycin Consequences: Higher Increasing Search for Incidence of use of alternative Enteritis/ therapeutic Gut Dys- Antibiotics Stabilizers bacteriosis 2 www.miavit.com

  3. Intention of AB Growth Promotors Reduction of Subclinical infections  Reduction of microbial metabolites in the gut, which will limit performance of animals  Reduction of Microbs which will utilize Nutrients  Increase of Nutrient absorption by the animal trough a thinner gut wall.  Lower Higher End Better FCR Mortality weights 3 www.miavit.com

  4. Example Flavomycin  Phosphoglykolipid from Streptomyces ghanaensis  1-2 mg/kg feed  Anitmicrobial action against gram positive Baktria inside the gut (no transmission to the blood stream)  Mode of action:  Inhibition of growth of gram positive bakteria by inhibiting the Biosynthesis of Murein (structual substance of the cell wall)  Cell death 4 www.miavit.com

  5. Currative AB in Poultry  Gut health  Respiratory system 5 www.miavit.com

  6. Wind of change – other possibilities besides AB Organic Herbs, Probiotics Enzymes Prebiotics acids essential Oils NSP Enzymes: Influence on feed Indirect inhibiton of pH reduction in reduction of Oligosaccharides intake, Enzym harmfull bacteria feed or intestine viskosity  better which will feed the segregation, digestiability of positive microbiota Impact on nutrients Mikrobiotia, Respiratory tract Competitve Enzyme activation, exclusion therefore better Modification of Influence on digestability Microbiotia, which bactieria which are will lead to increase deconjugating bile of lactic acid and Long time of acid (Clostridia) propionic acid application needed production to transform gut mircobiota 6 www.miavit.com

  7. Back in 1948, Dr. Hans W. Niemeyer started as a veterinary surgeon specialised on animal feeds

  8. Animal Health – most important point to minimize antibiotics in livestock Factorial diseas Fa ase Animal al prod oduc uction on- Animal al Hygien ene husba bandr dry managem emen ent nut utri rition on 30% sparing ng 30% 70% sparing 70 ng pote tential al to to decre rease antib ibio iotics ics potent entia ial o l on th the feed eed side de Yes es, N Nut utrition n ha has clearly ly an n imp impact to to th the hea health, bu , but t …….

  9. Intestinal flora of chicken D 0-3 D 7 D 14-15 D 5 Colonization by Domination of Risk of Dysbacteriosis First appearence Enterobacteria, Lactobacillus (Imbalance of enterococcus, of Lactobacillus clostridia different bacteria) (Picture: De Gussem et al. 2014)

  10. Intestinal flora of chicken Dominant • 90% Bifidobacteria, Lactobacillus intestinal flora Sub-dominant • 9% E.Coli, Enterococcus, Streptococcus intestinal flora • 1% Proteus, Clostridium, Pseudomonas, Rest Candidas

  11. Gut health Damaged villi Healthy villi = bad absorption of nutrients = good absorption of nutrients = bad performance = good performance (Soruce: P . Augustin) 11 www.miavit.com

  12. Egg shell stability Picture: as the hens are ageing, shell strength decreases (Ron Eek, Lohmann Tierzucht, Poultry Focus Asia, 2016) 12 www.miavit.com

  13. Intestinal flora of chicken Wet-dropping, Diarreah (Pictures: Julia Aka)

  14. Bacillus amyloliquefaciens ATCC 23350 MiaClost (Bacillus Subtillis) Clostridium perfringens CCM 7176 Clostridium perfringens ATCC 13124 Clostridium perfringens NCTC 8798 14

  15. Layer vs Broiler breeding Long life Short life

  16. Gene Genetical pr progr gress in in br broilers 1957 vs. 2001 Athens-Canadian Random-bred Control (1957) vs. Ross 308 (Havenstein et al., 2003 in AminoNews, Special Edition, Degussa Feed Additives)

  17. Breeding schema for layers (Source: LTZ, 2012) (Source: ISA) 17 www.miavit.com

  18. Intestinal flora of chicken Relation intestine length : body size Cattle 30 : 1 Pig 25 : 1 Poultry 8 : 1 (Source: Aviagen)

  19. Economics in Egg production (Source: Hatchery Practice 32/7 2018)

  20. The Fee he Feed d Pyrami mid Our ur special and nd professi ssional Vitamins, etc. key ey know nowledge Minerals Protein Sources Our ur profes essio ional technical Sup uppor ort Energy Sources

  21. Supplemention to meet requirements of broilers 66 % Sorghum Feed:  27,5 % Groundnut meal  0,5 % Calcium Carbonate  1 % Plant oil  1,2 1,2 Goal Feed 1,1 1,1 1 1 0,9 0,9 0,8 0,8 % in feed 0,7 0,7 0,6 0,6 0,5 0,5 0,4 0,4 0,3 0,3 0,2 0,2 0,1 0,1 0 0 dig. Lysine dig. Methionine dig. Meth.+Cys. dig. Threonine dig. Tryptophane 21 www.miavit.com

  22. Supplemention to meet requirements of broilers 63,2 % Sorghum Feed:  31 % Groundnut meal  + 3,5% Miavit Premix Broiler 0,5 % Calcium Carbonate  1,8 % Plant oil  1,2 1,2 Goal Premix Feed 1,1 1,1 1 1 0,9 0,9 0,8 0,8 % in feed 0,7 0,7 0,6 0,6 0,5 0,5 0,4 0,4 0,3 0,3 0,2 0,2 0,1 0,1 0 0 dig. Lysine dig. Methionine dig. Meth.+Cys. dig. Threonine dig. Tryptophane 22 www.miavit.com

  23. The impact of feed technology on the performance

  24. Characteristics of feed intake in poultry Table: Influence of Feed Particle Size on Gizzard and Small Intestine in Broilers Parameter fine medium coarse Sign.(p<) Weight Gizzard* 3,95 5,50 4,97 0,01 Content of Gizzard* 1,38 2,96 3,02 0,01 Weight Small Intestine* 6,61 5,71 5,98 0,05 Content of Small Intestine* 5,99 5,67 4,97 0,05 pH-Value Gizzard 3,47 3,03 2,74 0,01 (* % of Body Weight) (mod. Nir, 1997)

  25. Trial antibiotic free broilers

  26. Design of Trial in total 8 houses of ~ 50.000 birds (Hubbard F15)  Cage housing  4 houses control: (no. 13, 15, 17, 19)  2 feed antibiotics (Flavoph., Enradin)  2 coccidiostats (Nicarbacin, Narasin)  2 antibiotic treatments by water: day 1-5 Enrofloxacin , day 20-25 Ciprofloxacin  4 houses trial: (no. 12, 14, 16, 18)  no feed antibiotics  no antibiotic water treatments  coccidiostat: Salinomycin  adapted feed formulation  adapted premix formulation  26 www.miavit.com

  27. Housing 27 www.miavit.com

  28. Problems in Broiler Flocks  Enteritis in older Flocks  Bad Digestion 28 www.miavit.com

  29. Feed Quality in Trial and Control Group % Protein in feed Start 0-10 0-10 Trial Contr. 27 22 Kcal 2850 2970 17 12 Starter Protein 21,24 23,02 Tial Control Kcal / kg of feed 3200 Lysine 1,34 1,44 3000 Whole 0 0 2800 wheat 2600 Starter Tial Control 29 www.miavit.com

  30. Results Prestarter 300 ● Red bars: Miavit trial 12 13 14 15 16 17 18 19 ● grey bars: Control 250 200 weight, g 150 100 50 0 10 age in days 30 www.miavit.com

  31. Feed quality in Trial and Control Group % Protein in feed Grower 11-16 11-16 22 Trial Contr. 20 18 16 Kcal 2947 3100 14 12 Grow I Tial Control Protein 20,47 21,51 Kcal / kg of feed 3200 Lysine 1,25 1,29 3000 2800 Whole 0 2600 wheat Starter Tial Control 31 www.miavit.com

  32. Results grower 1 (Body weight) 600 ● Red bars: Miavit trial 12 13 14 15 16 17 18 19 ● grey bars: Control 500 400 weight, g 300 200 100 0 15 32 www.miavit.com age in days

  33. Feed quality in Trial and Control Group % Protein in feed Grower 17-23 17-24 II Trial Contr. 22 Kcal 2953 3108 17 12 Grow II Protein 19,53 21,47 Tial Control Kcal / kg of feed Lysine 1,16 1,29 3200 3000 Whole 10% 10% 2800 wheat 2600 Grow II Tial Control 33 www.miavit.com

  34. Results grower II (Body weight) 1400 ● Red bars: Miavit trial 12 13 14 15 16 17 18 19 ● grey bars: Control groups 1200 1000 weight, g 800 600 400 200 0 25 age in days 34 www.miavit.com

  35. Feed quality in Trial and Control Group % Protein in feed Finisher 24-34 25-33 Trial Contr. 22 17 Kcal 3081 3100 12 Finish I Protein 18,78 19,00 Tial Control Kcal / kg of feed Lysine 1,09 1,07 3200 3000 2800 Whole 10% 10% wheat 2600 Finish I Tial Control 35 www.miavit.com

  36. 2500 ● Red bars: Miavit trial ● grey bars: Control groups 12 13 14 15 16 17 18 19 2000 1500 weight, g 1000 500 0 35 age in days 36 www.miavit.com

  37. Conclusion  Reduction of Antibiotic in the feed possible  Feed formulation has to be adapted  Feed does not become more expensive  Performance and weight gain can be on the same leve without AGPs  … fo for further er Informa mation MI MIAVIT T is is at t yo your ur servic ice! e!

  38. Thank you for your attention!

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