Karine Prado Karine Prado AQUAPORIN MONTPELLIER PhD INRA-CJS N A - PowerPoint PPT Presentation

Karine Prado

Karine Prado AQUAPORIN MONTPELLIER PhD INRA-CJS N A P P N A 10-2010 C. Maurel’s group S -P S -P 12-2013

Karine Prado EDINBURGH Post-Doc CJS 01-2014 A.J. Millar’s group 10-2015 AQUAPORIN MONTPELLIER PhD INRA-CJS N A P P N A 10-2010 C. Maurel’s group S -P S -P 12-2013

Karine Prado EDINBURGH Post-Doc CJS 01-2014 A.J. Millar’s group 10-2015 AQUAPORIN MONTPELLIER PhD INRA-CJS N A P P N A 10-2010 C. Maurel’s group S -P S -P 12-2013

Ostreococcus tauri: a minimal clock system Smallest free-living eukaryote Unicellular photosynthetic marine alga Reduced Small clock sequenced genome Conserved signalling 12.5 Mbp genome components encoding ~8,000 genes Reduced kinome Low genetic redundancy Reduced signalling complexity Simple cellular structure 1 mitochondrion 1 chloroplast Henderson et al. , (2007) PlosOne , Derelle et al. , (2006) PNAS , 1 Golgi Corellou et al. , (2009) Plant Cell

Ostreococcus tauri: a minimal clock system Smallest free-living eukaryote Unicellular photosynthetic Reduced TTFL marine alga Reduced Small clock sequenced genome Conserved signalling 12.5 Mbp genome components encoding ~8,000 genes Reduced kinome Low genetic redundancy Reduced signalling complexity Simple cellular structure 1 mitochondrion 1 chloroplast Henderson et al. , (2007) PlosOne , Derelle et al. , (2006) PNAS , 1 Golgi Corellou et al. , (2009) Plant Cell

Ostreococcus tauri: a minimal clock system Smallest free-living eukaryote Unicellular photosynthetic Reduced TTFL marine alga Reduced Small clock sequenced genome Conserved signalling 12.5 Mbp genome components encoding ~8,000 genes Reduced kinome Low genetic redundancy Reduced signalling complexity Simple cellular structure O. tauri is a suitable model to 1 mitochondrion identify core signalling components 1 chloroplast Henderson et al. , (2007) PlosOne , of eukaryotes Derelle et al. , (2006) PNAS , 1 Golgi Corellou et al. , (2009) Plant Cell

An ancestral non-trancriptional oscillator (NTO) Translational inhibitors TTFL O’Neill et al. , (2011) Nature

An ancestral non-trancriptional oscillator (NTO) Translational inhibitors TTFL O’Neill et al. , (2011) Nature, Edgar et al. , (2012) Nature Perodoxin oxidation

An ancestral non-trancriptional oscillator (NTO) Translational inhibitors TTFL NTO COUPLING O’Neill et al. , (2011) Nature, Edgar et al. , (2012) Nature Perodoxin oxidation

An ancestral non-trancriptional oscillator (NTO) Translational inhibitors TTFL NTO COUPLING O’Neill et al. , (2011) Nature, Edgar et al. , (2012) Nature Perodoxin oxidation

An ancestral non-trancriptional oscillator (NTO) Translational inhibitors Signalling ? TTFL NTO COUPLING O’Neill et al. , (2011) Nature, Edgar et al. , (2012) Nature Perodoxin oxidation Ancestral NTO requires cell signalling processes including protein kinases

An ancestral non-trancriptional oscillator (NTO) Clock Translational components inhibitors Signalling ? Time resolved  ? phosphoproteomics TTFL NTO ? COUPLING O’Neill et al. , (2011) Nature, Edgar et al. , (2012) Nature Pharmacological  clock modulation Perodoxin oxidation Ancestral NTO requires cell signalling ? processes including protein kinases

Acknowledgment