IDUN Intelligent oral Drug delivery Using Nano and microfabricated - PowerPoint PPT Presentation

IDUN – Intelligent oral Drug delivery Using Nano and microfabricated containers – The Team

Motivation and Perspectives Monodispersity and customised dosage Control of release kinetics and place Stabilize drugs Adhesion and unidirectional release in intestine Protection Combine drugs, in stomach permeation enhancers etc

Idea and novelty

Structure/activities 1. Container design optimization 2. Reservoir and lid 3. Surface structuring/coating A Polymer and drug Release and collection layer deposition of micropatches Embossing tool Biocompatible micro-containers B C D 4. Embossing tool B Barrier layer C D Mucoadhesive drug matrix Controlled release coating Release layer Handling layer Loading of drugs 5 Microsystem for in vitro characterization 6. In vitro and in vivo studies 7.

New results a) b) 100 µm 100 µm Biocomp. container Intestinal perfusion SU-8 containers with top coating Hydrogel ’blobs’ that swell In vivo studies