Hodgkin-Huxley model simulator Katrin Valdson Kristiina Pokk Marit Asula Tartu 2015
Introduction I = g(V − E )+ gn ⁴ (V − E)+ g ₐ m³h(V − E ₐ )
Simulator
Simulator
Topics of the simulator exercises Part I: Equilibrium Potential Part II: Membrane Potential Part III: The Action Potential Part IV: The Fast Sodium Channel Part V: The Delayed Rectifier Part VI: Voltage-Gated Channel Parameters
TTX ● neurotoxin ● found in pufferfish, octupuses, marine worms, amphibians ● deadly in very small amounts ● blocks Na ion channels ● prevents action potential from happening
TEA ● Tetraethylammonium ● found in simple salts ● used in pharmacological research ● blocks K ion channels ● prolonged action potential
Pronase ● group of proteolytic enzymes ● extracellular fluid of a species bacteria in soil ● blocks only the Na inactivation gate ● results in prolonged action potential
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