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Healthy Aims Overview Healthy Aims Project IST-2002-1-001837 . - PowerPoint PPT Presentation

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Healthy Aims Overview Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk The Healthy Aims IST Project 25 EU partners will develop a range of medical implants

  1. Healthy Aims Overview Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  2. The Healthy Aims IST Project • 25 EU partners will develop a range of medical implants including: Retina implant Cochlear implant FES system for lower and upper limbs Sphincter sensor Glaucoma sensor Pressure sensor for brain cavity and aorta Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  3. Intracranial Pressure Sensor Gyro Glaucoma Sensor Retina Implant IMU for Human Body Motion Cochlear Implant Accelerometer Functional Electrical Sphincter sensor Stimulation Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  4. The medical devices will utilise these technologies Implantable energy source (conventional and fuel cell). Body Area Network to communicate from in or on the body to base station up to 3m away. Micro-electrodes on non Silicon substrates. Micro-assembly methods for true 3D systems. Biomaterials suitable for interfacing devices in the body. Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  5. RF Comms Biomaterials Biofuel Cells Sensor or control Base station with MICS & antenna Wake-Up Link RF PCB Base Application RF Chip Station Wake-Up Chip Wake-Up Data RF Circuit Interface MACMICS RF RF Data Link MICS RF MAC Battery 403 MHz 3 meters max. Fouling on electrode surface blocking conductivity to nerves Neurite growth on surfaces Micro-connectors Micro-electrodes and nano- electronics Encrustation forming on foreign bodies Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  6. The exploitation requires Medical devices manufacturers Medical Systems suppliers Medical Approvals bodies Surgeons and clinical teams from hospitals Medical Service providers e.g Social Services Local medical practices Purchasing teams, e.g NHS in the UK Medical Insurance groups Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  7. The Healthy Aims Team • Research Groups in micro and nano technology • Biomaterials experts • RF communications experts • Power sources experts • Design teams • Medical Device manufacturers • Surgeons and clinical teams, including ethics These all came from the NEXUS Medical Devices USC and includes 6 SMEs from across the EU. Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  8. Wireless communications Specifically to meet the following specification � MICS compatible (402 – 405 MHz / 433MHz) � Downlink 250 Kbit/s, Uplink 500Kbit/s � Power output limited to 25 µ W EIRP � Range 1.5 – 3.0 metres � Housekeeping software Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  9. System Overview Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  10. Micro scale electrodes Processes can provide both high density electrodes and “first level” interconnections. Electrode tips can be formed in 3D. Interaction with the biomaterials work package will define electrode shapes for improved electrode–tissue interaction Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  11. Packaging & Assembly Materials Materials Micromachining Micromachining I nterconnect I nterconnect Encapsulation and Encapsulation and Protection Protection Assembly and Verification Assembly and Verification Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  12. Cochlear implant, CTC Overall connector design microTEC dummy connector attached to electrode by CTC Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  13. Biomolecular surface modification can be used to organise cell growth. • Micro contact printing of collagen on glass substrate. PDMS Cells Silicon Scale bar 100 µm Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  14. Battery Cell Design R.Gardette/CEA Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  15. WHAT I S A BI OFUEL CELL Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  16. IMIT 3-axis Gyro Progress Evaluation of the ASIC for high integration level Evaluation board Single axis sensor Detail of the MEMS structure In cooperation with Melexis (B) and XFab (D) Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  17. Accelerometer Progress Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  18. Human body motion - Salford Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  19. Application of IMU in the project • The primary application area in HA is in Advanced Functional Stimulation • All current systems are controlled using basic switches or FSRs, which severely limit their usability • HA will demonstrate the use of the IMU as the sensor system in the control of an advanced implantable Functional Stimulation System. Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  20. Cochlear Implant Present commercial product Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  21. Glaucoma Sensor - Wired sensor Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  22. Glaucoma sensor - Trials with first version Trials with first version of wired lens: • Trials at Fribourg Cantonal Hospital • Only sane patients tested • Protocol did not allow to modify the IOP during trials Protocol: • Lens traceability & patient information • Anesthesia with oxybuprocain • IOP measurement on both eyes with Goldman and TonoPen, Biometry of the eye. • Placing the lens on the eye done by MD 1) Open eye : 3 positions (sitting / lying / standing) & Valsalva maneuver 2) Closed eye: 3 positions & Valsalva maneuver • Measurements with TonoPen on second eye at every step in the protocol. • Feedback from patient at the end of session Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  23. Our Approach – The Learning Retina Implant Glasses + Camera Chip (integrated) Pocket Processor Retina Implant Visual Cortex Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  24. Upper Limb Implant • Mixed monopolar electrodes • Common anode • Choose up to 6 from 9 stimulation points Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  25. Sphincter sensor Progress Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  26. Intracranial Pressure Sensor Prototype Telemetry unit Conducting lead Measuring head External reader/ writer device Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  27. Intracranial Pressure Sensor Application: ICP • Hydrocephalus describes state of excessive accumulation of CSF within the fluid system of the head causing high intracranial pressure • Therapy: draining CSF from the CNS by shunts – Shunt failure • Approx 40 per 100,000 Individuals have shunts in www.motiv-medtech.com place – 125,000 p.a. in USA Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

  28. Applications: EVAR (2) • Endoleak development can lead to pressurization and increased risk of rupture – Continuous surveillance required • Standards of clinical surveillance – Contrast media enhanced CT scanning – MRI – Pressure measurement via L. A. S anchez et al. in J Vasc S urg, 26,2; 1997 percutaneous puncture Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk S ccess of therap

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