development of
play

Development of breast tumours models database Kristina Bliznakova - PowerPoint PPT Presentation

H2020-TWINN-2015, Grant Agreement 692097 Development of breast tumours models database Kristina Bliznakova Katholieke University of Leuven Technical University of Varna University of Naples Federico II Belgium Bulgaria Italy Laboratory


  1. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  2. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  3. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  4. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  5. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  6. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  7. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  8. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging M 3D dilation Modelling is based on random walk is a random process consisting of a sequence of discrete 3D erosion steps of fixed length. At each step, the walk goes randomly a unit distance along one of the neighbor pixels.

  9. Mathematically modelled lesions - irregular masses M - tumor size N brownian_runs N run_length 3D random walk 3D averaging 3D dilation 3D erosion

  10. Models 3D dilation M = 200 N brownian_runs = 300 N run_length =200 3D averaging 3D erosion

  11. Models

  12. Evaluation

  13. nn_200_2000_2000_4_256x256 90 o nn_200_2000_2000_4_256x256 0 o NN_1_200_2000_2000_4 nn_200_2000_3000_4_256x256 0 o nn_200_2000_3000_4_256x256 90 o NN_1_200_2000_3000_4

  14. nn_200_2000_4000_4_256x256 9 0 o nn_200_2000_4000_4_256x256 0 o NN_1_200_2000_4000_4 nn_200_2000_5000_4_256x256 0 o nn_200_2000_5000_4_256x256 90 o NN_1_200_2000_5000_4

  15. nn_500_500_1000_4_256x256 0 o nn_500_500_1000_4_256x256 90 o NN_1_500_500_1000_4 nn_500_500_2000_4_256x256 90 o nn_500_500_2000_4_256x256 0 o NN_1_500_500_2000_4

  16. nn_500_500_3000_4_256x256 0 o nn_500_500_3000_4_256x256 90 o NN_1_500_500_3000_4 nn_500_500_4000_4_256x256 90 o nn_500_500_4000_4_256x256 0 o NN_1_500_500_4000_4

  17. nn_500_500_5000_4_256x256 0 o nn_500_500_5000_4_256x256 90 o NN_1_500_500_5000_4 NN_1_500_1000_1000_4_300x 90 o NN_1_500_1000_1000_4_300x 0 o NN_1_500_1000_1000_4

  18. nn_500_1000_2000_4_300x 300 0 o nn_500_1000_2000_4_300x 300 90 o NN_1_500_1000_2000_4 nn_500_1000_3000_4_300x 300 90 o nn_500_1000_3000_4_300x 300 0 o NN_1_500_1000_3000_4

  19. nn_500_1000_4000_4_300x 300 90 o nn_500_1000_4000_4_300x 300 0 o nn_500_1000_5000_4_300x 300 0 o nn_500_1000_5000_4_300x 300 90 o NN_1_500_1000_5000_4

  20. nn_500_2000_1000_4_ 450x450 0 o nn_500_2000_1000_4_ 450x450 90 o NN_1_500_2000_1000_4 nn_500_2000_2000_4_ 450x450 0 o nn_500_2000_2000_4_ 450x450 90 o NN_1_500_2000_2000_4

  21. nn_500_2000_3000_4_ 450x450 0 o nn_500_2000_3000_4_ 450x450 9 0 o nn_500_2000_4000_4_ 450x450 0 o nn_500_2000_4000_4_ 450x450 90 o

  22. nn_500_2000_5000_4_ 450x450 0 o

  23. nn_500_3000_1000_1_ 550x550 90 o nn_500_3000_1000_1_ 550x550 0 o NN_1_500_3000_1000_1 NN_1_500_3000_1000_4 nn_500_3000_1000_4_ 550x550 0 o nn_500_3000_1000_4_ 550x550 90 o

  24. Ray step 0.05 mm nn1000_1000_1000_4_256x256 NN1000_1000_1000_01_300x300 NN1000_1000_1000_01_400x400 NN_1000_1000_1000 Nn_1000_1000_2000_4_256x256 0 o Nn_1000_1000_2000_4_256x256 90 o NN1000_1000_2000

  25. NN1000_1000_3000 nn_1000_1000_3000_4_400x400 0 o nn_1000_1000_5000_4_400x400 90 o nn_1000_1000_4000_4_400x400 90 o nn_1000_1000_4000_4_400x400 0 o NN1000_1000_4000

  26. Under development Objective evaluation CC view MLO view Gospodinova, 2018, ACT2018, Ohrid Subjective evaluation The created Images are stored in a database and will be used in the further assessment, 4 AFC research and educational activities.

  27. Database organisation

  28. Database web-based interface

  29. Database organisation

  30. Database organisations

  31. Database organisation

  32. Irregular masses - description

  33. Outline • Exploitation of results in practice

  34. Exploitation of results • Research • Education • Fun

  35. Exploitation of results • Research

  36. Research To study novel breast imaging techniques

  37. Creation of breast model  Simulation of the compression procedure Dukov et al, IUPESM, 2018

  38. Compressed breast model 3D view slice Dukov et al, IUPESM, 2018

  39. Example X-ray tube Software + 25 0 - 25 0 X-ray Imaging source-detector distance source-object distance Simulators software breast phantom detector

  40. Images obtained with the software phantom (a) (b) (c) Dukov et al, IUPESM, 2018

  41. Phantoms for the study  Container – Clear resin;  Breast shape – Clear resin;  Glandular tree – Clear resin;  Glandular tree – Clear resin;  Water;  Animal fat;  Thickness – 49 mm;  Thickness – 31 mm;  Wall thickness – 2.4 mm.  Wall thickness – 1.7 mm.

  42. Phantoms for the study  27 spheres from Gray resin;  ~ 33000 PMMA spheres;  radiuses [6 - 13] mm;  radiuses [0.79 - 7.94] mm;  white resin container;  PMMA container;  animal fat;  water.  wall thickness 3 mm.

  43. Setup  60keV  Planar images  Tomosynthesis - 25 projection images

  44. Exploitation of results • Education

  45. Eutempe-net training course, Varna 22-26/05/2017 • How to model x-ray imaging chain; • How to model breast; • How to model breast cancer; • How to work in a team; • How to write abstracts; • How to present a scientific work.

Recommend


More recommend