IBA COSTIS Installation • COmpact Solid Target Irradiation System (COSTIS) delivered with flange for IBA 18/9 installation • Custom flange designed / fabricated for PETtrace installation at IBA-MI site at Virginia Commonwealth University, Richmond, VA
IBA Target Control System • Programmable Logic Controller (PLC) with touchscreen buttons and target status display • Automates loading and unloading of target disk • Provides controls for remote closure of target disk pig
IBA Target Control Terminal Box • Cable penetration into vault/shield required • Distributes control signals to target pneumatic cylinders, air dry valve, and solenoid cooling system valves
IBA Cooling System • TeO 2 exhibits low • Water cooling for both thermal conductivity target disk and (~30 mW/K-cm) graphite collimator • Vapor pressure is • Helium cooling for significant prior to disk cavity w/venting melting prior to unloading • Target oxide cooling • Cooling drain/air becomes paramount drying for disk
IBA Solid Target Preparation • Platinum disk 24mm diameter w/ circular 12mm cavity—high thermal conductivity • Isotopically enriched TeO 2 melted into cavity • Typically 200 mg w/5% Al 2 O 3 • Annealed to convert TeO 3 to TeO 2
IBA Irradiation Parameters • Optimal energy range 9-13 MeV • Higher energies (~15 MeV) require thick target (~1 mm) to fully stop beam (SRIM2000 transport code) • Nominal power dissipated by target ~300W given sufficient cooling reserves and necessary beam quality
IBA Optimizing Production Yield • 124 Te enrichment Typical Production Yields 100 extremely high 90 80 70 60 • Thick target mCi 50 40 30 • Cooling reserves! 20 10 0 0 50 100 150 200 250 • Favorable beam uA-h Agreement with predicted profile 0.54 mCi (20 MBq)/uA-h • Optimal energy
IBA Target Degradation • Chemical—volatile organic compounds break down oxide matrix to elemental Te • Corrosion—disk alloy; de-ionized cooling • Mechanical—scratch results in He leak • Irradiation— 194 Au (39.5h), 196 Au (6.18d) from Pt isotopes • Thermal—reannealing during bombardment or migration of matrix during recovery
IBA Radioiodine Recovery • Thermochromatographic separation associated with high yields • Diffusion/transport/trapping regimes optimized • Quartz tube furnace did not disappoint! • Nominally 90-95% trapping yield using 0.02M NaOH
IBA Radionuclidic Purity • HPGe gamma spectrometry per ANSI N42.14, calibrated with 152 Eu standard • 18 F and 123 I impurities minimized at EOS • 125 I, 126 I, 130 I, 131 I below detection limit of 0.1%
IBA Quality Control • Radiochemical purity • pH by HPLC to determine • LAL oxidation species • Sterility • Chemical purity by • Visible impurities UV spectrophotometry for Te
IBA Next Steps • COSTIS proved reliable and well engineered for commercial 124 I production • Adaptable to any internal beam cyclotron in the IBA fleet • 124 I production ramping up • 64 Cu, 76 Br targets in pipeline
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