Chemspace Modifiable Fragments Acid fragments and Amine fragments - PowerPoint PPT Presentation

Jan 28, 2024 •430 likes •503 views

Chemspace Modifiable Fragments Acid fragments and Amine fragments Description Presence of modification points in the FBDD hits enables their further developability and/or combining of the different hits in one larger molecule. We created two

Chemspace Modifiable Fragments Acid fragments and Amine fragments
Description Presence of modification points in the FBDD hits enables their further developability and/or combining of the different hits in one larger molecule. We created two different sets, Acid Fragments and Amine Fragments. For Chemspace Acid Fragments we selected compounds possessing at least one carboxylic acid group. The compounds are convenient for further modification and fragment follow ‐ up. Chemspace Amine Fragments is a set of small polar molecules containing at least one primary or secondary amino group. We selected fragment ‐ like compounds that have high fsp3 and moderate TPSA and are convenient for further modification and fragment follow ‐ up.
Selection Chemspace Acid Fragments Chemspace Amine Fragments Comply with Ro3 Comply with Ro3 • • Contain free carboxylic group (CO 2 H) Contain free amino group (NH and NH 2 ) • • Library size : Library size : 9 736 in-stock compounds 1 093 in-stock compounds 33 678 make-on-demand compounds 33 528 make-on-demand compounds You can order full set or selected subset based on your criteria; all compounds are supplied as powders, solutions, or dry films. Please contact us at sales@chem-space.com for more information.
Chemspace Compound sets Discover our Fragment Libraries : General Fragments Fluorine and Heavy Fragments • • 3D-Shaped Fragments Selected Fragments • • Acid and Amine Fragments Singleton Fragments • • Covalent Fragments Saturated and Spiro Fragments • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Chemspace Compound sets Discover our Screening compounds : ChEMBL analogs High QED compounds • • CNS-Focused library Phenotypic Screening set • • Covalent Modifiers PPI Modulators • • Drug Impurities Pre-Plated compounds • • Drug Repurposing RNA-Targeted library • • Framework-Derived set Virtual Screening set • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Thank You! The Chemspace Team

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Chemspace Heavy Fragments Description Aside of NMR, X ray crystallography is a technique that

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Chemspace Covalent Modifiers Description Compounds that possess moieties able to react with

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Chemspace Covalent Fragments Description Many drugs people have been using for a really long

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Chemspace Phenotypic Screening Set Description Phenotypic screening (PS) is one of the two major

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