Chemspace Heavy Fragments Description Aside of NMR, X ray - PowerPoint PPT Presentation

Mar 02, 2023 •379 likes •455 views

Chemspace Heavy Fragments Description Aside of NMR, X ray crystallography is a technique that is often used to determine/prove the interaction of the molecule with target protein. Fragments for this type of screening are brominated small

Chemspace Heavy Fragments
Description Aside of NMR, X ‐ ray crystallography is a technique that is often used to determine/prove the interaction of the molecule with target protein. Fragments for this type of screening are brominated small molecules. Bromine atom causes anomalous diffraction of the X ‐ rays and can be clearly detected in the crystal of the protein. In addition, bromine provides clear attachment point for different types of substituents and enable quick follow up.
Selection Chemspace Heavy Fragments library consists of compounds that Comply with Ro3 • No PAINS and “toxic” moieties • Contain one Bromine or one Iodine atom • Contain no more than one Chlorine atom • Library size : 3 132 in-stock compounds 20 444 make-on-demand compounds You can order full set or selected subset based on your criteria; all compounds are supplied as powders, solutions, or dry films. Please contact us at sales@chem-space.com for more information.
Chemspace Compound sets Discover our Fragment Libraries : General Fragments Fluorine and Heavy Fragments • • 3D-Shaped Fragments Selected Fragments • • Acid and Amine Fragments Singleton Fragments • • Covalent Fragments Saturated and Spiro Fragments • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Chemspace Compound sets Discover our Screening compounds : ChEMBL analogs High QED compounds • • CNS-Focused library Phenotypic Screening set • • Covalent Modifiers PPI Modulators • • Drug Impurities Pre-Plated compounds • • Drug Repurposing RNA-Targeted library • • Framework-Derived set Virtual Screening set • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Thank You! The Chemspace Team

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