Chemspace Drug Impurities Description Drug impurities are - PowerPoint PPT Presentation

Apr 01, 2023 •749 likes •818 views

Chemspace Drug Impurities Description Drug impurities are undesirable compounds that accompany the main drug. They are the result of side processes that are inevitable in large-scale organic synthesis. It is very important to collect data on

Chemspace Drug Impurities
Description Drug impurities are undesirable compounds that accompany the main drug. They are the result of side processes that are inevitable in large-scale organic synthesis. It is very important to collect data on the impurities that drugs may have to control the amount of these side substances in the final substance. These impurities are often very hard to remove and are a subject to a drug quality control. For synthetic drugs, thresholds for the number of impurities are usually available.
Selection Chemspace offers a set of the known drug impurities that could be used as references for quality control purposes. Ordering options: full set or cherry-picked selection. Nearly 400 impurities • 280 drugs from either US Pharmacopeia or European Pharmacopoeia • Library size : 372 in-stock compounds You can order full set or selected subset based on your criteria; all compounds are supplied as powders, solutions, or dry films. Please contact us at sales@chem-space.com for more information.
Chemspace Compound sets Discover our Fragment Libraries : General Fragments Fluorine and Heavy Fragments • • 3D-Shaped Fragments Selected Fragments • • Acid and Amine Fragments Singleton Fragments • • Covalent Fragments Saturated and Spiro Fragments • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Chemspace Compound sets Discover our Screening compounds : ChEMBL analogs High QED compounds • • CNS-Focused library Phenotypic Screening set • • Covalent Modifiers PPI Modulators • • Drug Impurities Pre-Plated compounds • • Drug Repurposing RNA-Targeted library • • Framework-Derived set Virtual Screening set • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Thank You! The Chemspace Team

Recommend

Chemspace Drug Repurposing Description Drug discovery is a cost-consuming process. Different

Chemspace Drug Repurposing Description Drug discovery is a cost-consuming process. Different strategies exist to reduce the costs and maximize the outcome. Drug repurposing is one of the approaches, also referred to as drug repositioning or

603 views • 6 slides

Chemspace Phenotypic Screening Set Description Phenotypic screening (PS) is one of the two major

Chemspace Phenotypic Screening Set Description Phenotypic screening (PS) is one of the two major approaches at early stage drug discovery projects, apart from the target-based screens. PS is focused on the overall effect a drug molecule causes

337 views • 6 slides

Chemspace Covalent Modifiers Description Compounds that possess moieties able to react with

Chemspace Covalent Modifiers Description Compounds that possess moieties able to react with biological molecules in the cell have been overlooked in drug discovery research projects for a long time. Character of the investigation did not allow

120 views • 7 slides

Chemspace Saturated Fragments Description With shift from the highly aromatic/olefinic compounds

Chemspace Saturated Fragments Description With shift from the highly aromatic/olefinic compounds to the fsp3-enriched ones, toxic properties of the drug candidates have had tendency to lower, and ADMET profiles, in general, have changed

113 views • 7 slides

Impurities in drug substances and medicinal products Hilda K szegi-Szalai Ph.D London,

Impurities in drug substances and medicinal products Hilda K szegi-Szalai Ph.D London, 27.10.2009 Outline of the presentation Principles of the assessment of impurities References Evaluation of the purity of synthetic drug

450 views • 41 slides

Chemspace General Fragments Description Fragment-based approach has emerged as a powerful tool

Chemspace General Fragments Description Fragment-based approach has emerged as a powerful tool in modern drug discovery. Most of the hits from conventional screening would hardly fit the Lipinski rules, not to say the Ro4. Thus, stricter rules

326 views • 7 slides

Chemspace Heavy Fragments Description Aside of NMR, X ray crystallography is a technique that

Chemspace Heavy Fragments Description Aside of NMR, X ray crystallography is a technique that is often used to determine/prove the interaction of the molecule with target protein. Fragments for this type of screening are brominated small

455 views • 6 slides

Chemspace Framework-Derived Set Description We are willing to provide our users with various

Chemspace Framework-Derived Set Description We are willing to provide our users with various tools and services to simplify selection of the compounds from our database. Among the tools, we have fast online chemical search, custom

261 views • 6 slides

Chemspace KNIME nodes Chemspace Search Chemspace KNIME nodes Chemspace Search and Chemspace

Chemspace KNIME nodes Chemspace Search Chemspace KNIME nodes Chemspace Search and Chemspace Expanded Search nodes Source: - Chemspace database , 130 million molecules - REAL Database , 720 million molecules Search options: -

653 views • 8 slides

Chemspace Selected Fragments Description Hit follow-up usually shifts its physChem parameters to

Chemspace Selected Fragments Description Hit follow-up usually shifts its physChem parameters to less desirable area. Initial library of high quality is a key to enhance the probability of hit obtaining and chance that is would be suitable for

837 views • 6 slides

Chemspace Covalent Fragments Description Many drugs people have been using for a really long

Chemspace Covalent Fragments Description Many drugs people have been using for a really long time are actually covalent binders. Examples of covalent modifiers include cancer and arthritis treatments and as antibacterial and antiviral agents.

207 views • 7 slides

Chemspace Virtual Screening Set Description Virtual screening (VS) has been a tool to identify

Chemspace Virtual Screening Set Description Virtual screening (VS) has been a tool to identify primary hits, to study structure-activity relationship, and to tweak the structures using scaffold hopping, to name a few. VS enables screening

259 views • 7 slides

Chemspace ChEMBL sets Description Searching analogs to compounds with the known activity is

Chemspace ChEMBL sets Description Searching analogs to compounds with the known activity is helpful in hit expansion and repurposing projects. ChEMBL database has become an important reference tool containing an information on potency,

338 views • 6 slides

Chemspace RNA-targeted library Description RNAs participate in more cell mechanisms than it has

Chemspace RNA-targeted library Description RNAs participate in more cell mechanisms than it has been thought before. Aside from transferring information from the DNA, this type of biomolecules appears to affect numerous cell processes: very

426 views • 6 slides

Control Strategies of Genotoxic Impurities in Drug Substance & Product Presented by : Dr.

27/02/2020 Control Strategies of Genotoxic Impurities in Drug Substance & Product Presented by : Dr. Anuj Prakash Senior Scientific Officer Indian Pharmacopoeia Commission Ministry of Health & Family Welfare Government of India 1

626 views • 8 slides

Chemspace Spiro Fragments Description Spirocyclic fragment contributes both to rigidity and

Chemspace Spiro Fragments Description Spirocyclic fragment contributes both to rigidity and spherical form of the molecule. Moreover, further modification of the rings that are included into the spirosystem expands the molecule in 3D. This

205 views • 7 slides

Chemspace Modifiable Fragments Acid fragments and Amine fragments Description Presence of

Chemspace Modifiable Fragments Acid fragments and Amine fragments Description Presence of modification points in the FBDD hits enables their further developability and/or combining of the different hits in one larger molecule. We created two

503 views • 6 slides

Chemspace Fluorine Fragments Description Presence of Fluorine atom has been noticed to improve

Chemspace Fluorine Fragments Description Presence of Fluorine atom has been noticed to improve overall ADMET properties, which includes improving metabolic stability and increasing of bioavailability through increasing lipophilicity, decreasing

241 views • 6 slides

Chemspace 3D-Shaped Fragments Description The shape of the molecule is an important factor in

Chemspace 3D-Shaped Fragments Description The shape of the molecule is an important factor in its affinity to the binding site. Thanks to its shape, the molecule could become a specific key to the host molecule. Fragment libraries mostly

349 views • 7 slides

Chemspace KNIME nodes Expanded Search Chemspace KNIME nodes Chemspace Search and Chemspace

Chemspace KNIME nodes Expanded Search Chemspace KNIME nodes Chemspace Search and Chemspace Expanded Search nodes Source: - Chemspace database , 130 million molecules - REAL Database , 720 million molecules Search options: -

476 views • 8 slides

Chemspace Pre-Plated Compounds Description Discover our sets of Pre-Plated compounds! Fragments

Chemspace Pre-Plated Compounds Description Discover our sets of Pre-Plated compounds! Fragments LeadLike The large Hit Discovery set is assembled of 5 focused subsets: Representative, Unique, DrugLike, LeadLike, DrugLike and Fragments.

101 views • 6 slides

Prevention of Contamination with Nitrosamine Impurities Sartans with Nitrosamine impurities -

Prevention of Contamination with Nitrosamine Impurities Sartans with Nitrosamine impurities - Lessons Learnt Exercise Interested Parties Meeting EMA, Amsterdam, 4 November 2019 Presented by Blanka Hirschlerov QWP vice-chair, Head of

966 views • 15 slides

Background on cases of sartans with N-nitrosamine impurities Sartans with N-nitrosamine

Background on cases of sartans with N-nitrosamine impurities Sartans with N-nitrosamine impurities Lessons Learnt Exercise Interested Parties Meeting EMA, Amsterdam, 4 November 2019 Presented by Andrei Spinei Manufacturing Quality and Supply

410 views • 14 slides

Quantum Impurities Out of Equilibrium Natan Andrei With collaborators: P. Mehta - Princeton C.

Quantum Impurities Out of Equilibrium Natan Andrei With collaborators: P. Mehta - Princeton C. Bolech - Rice A. Jerez - NJIT S.-P Chao - Rutgers G. Palacios - Rutgers Florence, September 2008 Quantum Impurities out-of-Equilibrium The

508 views • 28 slides