Chemspace Phenotypic Screening Set Description Phenotypic - PowerPoint PPT Presentation

Aug 26, 2022 •263 likes •337 views

Chemspace Phenotypic Screening Set Description Phenotypic screening (PS) is one of the two major approaches at early stage drug discovery projects, apart from the target-based screens. PS is focused on the overall effect a drug molecule causes

Chemspace Phenotypic Screening Set
Description Phenotypic screening (PS) is one of the two major approaches at early stage drug discovery projects, apart from the target-based screens. PS is focused on the overall effect a drug molecule causes in the cell rather than an effect found for a single target. In addition, PS can reveal much more information on the disease phenotype: it emerges in identifying all the targets associated with this phenotype, not to mention that new non-described targets could be discovered. Its another advantage is in the simultaneous control of the cell permeability and toxicity of the screened compounds. The target identification in PS is a complex problem but the outcome could be very attractive: a number of new, first-in-class drugs have been discovered through phenotypic screens.
Selection To create Chemspace PS set , we have selected the compounds with activity annotations in ChEMBL from our Screening Compounds collection. - Favorable PhysChem profiles - No PAINS and Toxic fragments - Annotated with UniProt codes Library size : 42 176 in-stock compounds You can order full set or selected subset based on your criteria; all compounds are supplied as powders, solutions, or dry films. Please contact us at sales@chem-space.com for more information.
Chemspace Compound sets Discover our Fragment Libraries : General Fragments Fluorine and Heavy Fragments • • 3D-Shaped Fragments Selected Fragments • • Acid and Amine Fragments Singleton Fragments • • Covalent Fragments Saturated and Spiro Fragments • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Chemspace Compound sets Discover our Screening compounds : ChEMBL analogs High QED compounds • • CNS-Focused library Phenotypic Screening set • • Covalent Modifiers PPI Modulators • • Drug Impurities Pre-Plated compounds • • Drug Repurposing RNA-Targeted library • • Framework-Derived set Virtual Screening set • • All libraries’ names are clickable links. Visit www.chem-space.com/flyers to find more Chemspace presentations!
Thank You! The Chemspace Team

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