Wer kann uns helfen nicht krank zu werden? Auf dem Weg zum - PowerPoint PPT Presentation

Wer kann uns helfen nicht krank zu werden? Auf dem Weg zum künstlichen Knochen U. Wolfram Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland May 15, 2015

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Global Issues > ... > climate change > water > environment > disarmament > disease > age 2 http://www.un.org/en/globalissues/

Life Expectancy Male life expectancy (The UNDP Female life expectancy (The UNDP Human Development Report 2009) Human Development Report 2009) 3

Life Expectancy German Population 2014 Further Life Expectancy https://www.destatis.de/bevoelkerungspyramide/ 4

Population Pyramids http://populationpyramid.net/ 5

Osteoporosis Bone Mass Over Lifetime 1500 Bone Mass in g Calzium 1000 Menopause 500 0 0 20 40 60 80 100 Age in Years 6

Daily Clinical Cases Images partially adapted from en.wikipedia.org September 17 th , 2014. 7

Bone as Hierarchical Material Organ Level Mineralised Mineralised Single Lamellae Collagen Fibre Collagen Fibril 50-200 nm collagen molecules 3-7 μ m Microcracks ~ (300 x 1.5) nm ~200 μ m mineral platelets ~ (50 x 25 x 2) nm non-collageneous Haversian proteins channel Lamellar Structure Extra-Fibrillar Matrix upper tissue organisation levels lower tissue organisation levels Adapted from Reisinger, A. ILSB Vienna 8

Approach Dc Dt Ep E Ŝ 22 f( S , ρ , M ) Ŝ 33 Ŝ 11 t ϵ p σ t σ t* (1 - D t ) ϵ 0 k = σ t + σ c ϵ 0 X (1 - D c ) ϵ 0 σ c* ϵ 0 σ c c ϵ p Images partially adapted from en.wikipedia.org September 17 th , 2014. 9

Identify Mechanical Behaviour T ension Compression asymmetric, ctt Conewise Conewise g 2 E 33 ttt anisotropic Damagable Spring Hardening E 22 cct damageable D ω t P 2 ttc stiffness tensor D ω c g 3 E 11 ccc ctt tct g 1 g 2 E 33 tcc ttt E ω p E 22 cct E P 2 ttc g 3 multiple yield E 11 surfaces control ccc tct g 1 damaged plasticity tcc Asymmetric Strength Analysis 10

Whole Bone Simulation Courtesy of Dr. Ghislain Maquer. 11

Whole Bone Simulation 12 Courtesy of Dr. Hadi Hosseini.

Where To Go? Current state of knowledge Elasto-plastic and damage damaged elasto-plasticity mechanisms unknown Organ Level Mineralised Mineralised Single Lamellae Collagen Fibre Collagen Fibril 50-200 nm collagen molecules 3-7 μ m Microcracks ~ (300 x 1.5) nm ~200 μ m mineral platelets ~ (50 x 25 x 2) nm non-collageneous Haversian proteins channel Lamellar Structure Extra-Fibrillar Matrix upper tissue organisation levels lower tissue organisation levels 13 Adapted from Reisinger, A. ILSB Vienna

Where To Go? In Silico Optimisation of Treatment Strategies and Clinics Related Experiments In Silico Design of Production Processes Hierarchical Materials Based on In Silico Design 14

For what? To dance! 15

Thank you for your attention! 16 Nize Nicolai Schäfer „Edinburghpano09“ - selfmade. Licensed under CC BY-SA 3.0 via Wikimedia Commons