Understanding NIH: Drinking from the Fire-hose Rosemarie Hunziker, - PowerPoint PPT Presentation

Understanding NIH: Drinking from the Fire-hose Rosemarie Hunziker, PhD Tissue Engineering/Regenerative Medicine and Biomaterials Program Director National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) hunzikerr@mail.nih.gov 301-451-1609

T ODAY ’ S A GENDA : H OW TO S UCCEED AT NIH  What New in the Zoo: − NIH − NIBIB  Finding your NIH Niche − Each IC has a unique character − Get help from the inside  Writing Competitive Grants − Organize your team and plan − Specific Aims are the bedrock − Make reviewers your advocates

 What New in the Zoo − NIH

NIH “hot topics”  Precision Medicine Initiative  Discovery Science − BRAIN Initiative − Microbiome and health − Stem Cell Technology (tissue chips, regenerative medicine) − New Vaccines (Ebola, Flu, HIV…)  Translating discovery into health − Antimicrobial Resistance • national database of germ genomes • prize for better diagnostics (w/BARDA) • antibiotics and vaccines − Alzheimer’s Disease • basic research • epidemiology for risk/protective genes • early diagnosis and progression − Accelerating Medicine Partnership (Alzheimer’s, type 2 diabetes, lupus, rheumatoid arthritis)  Preparing a diverse and talented biomedical research workforce Source: http://www.nih.gov/about/director/budgetrequest/fy2016_directorsbudgetrequest_slides.pdf

http://www.nih.gov/precisionmedicine/

NIH and the BRAIN Initiative The human brain has 10 11 neurons, each connected to 10 4 other neurons. Sitting on your shoulders is the most complicated object in the known universe.  Goal: revolutionary new dynamic picture of the brain showing individual cells and complex circuits  Foundations: genome sequenced, CLARITY, fMRI, other high resolution tools  Planning: BRAIN 2025: A Scientific Vision  Funding: $46M (FY14), $85M (FY15), $135M+ (FY16) (requested) through targeted initiatives (basic neuroscience, classification of circuits, recording and modulating — non-invasively)  Others: DARPA, NSF, FDA, IARPA http://braininitiative.nih.gov/

Stimulating Peripheral Activity to Relieve Conditions (SPARC)  elucidating autonomic and sensory control of internal organ function for effective, minimally invasive neuromodulation therapy First Call: RFA-RM-15-002: Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18) 12 awards - Urinary tract, spleen, cardiovascular, upper airway, gastrointestinal tract - Approaches • Electrical interfaces • Viral and optogenetics • 3D imaging tools • Transgenic/animal models • Organoids • Ultrasound/infrared modulation • Microfluidic/wireless devices

Trans-NIH Programs Gabrielle Miller 4D Kids First Regulatory Nucleome Human * Gulf Oil Science Microbiome Spill * * Single Cell * Illuminating Stimulating Peripheral Analysis Protein Big Data to the Drugable Activity to Relieve Capture Knowledge Genome Conditions (SPARC) Library of Health Integrated Network- Economics Nanomedicine Biomedical Based Cellular Common Workforce Signatures HCS Research Fund (LINCS) Collaboratory Knockout Transformative – Catalytic Mouse Global Synergistic – Unique Early Independence Phenotyping Health Cross-cutting High-risk New innovators Research Bioinformatics and Pioneers NIH Glycoscience Computational Biology Transformative R01s Workforce Diversity Science of Metabolomics Epigenomics Behavior Molecular Genotype- Change Transducers of Undiagnosed Tissue Physical Activity Diseases * Expression * = watch for new initiatives http://commonfund.nih.gov/

“Biomaterials” in the NIH Portfolio (by percent of total investment, FY14) Total = 341 Awards NHGRI (1 = 0.5%) NEI ** NIBIB (11 = 0.7%) (46 = 4.2%) NINDS * (23 = 0.7%) * NIDDK (32 = 1.1%) ** *** NHLBI NIDCR (65 = 1.2%) (35 = 3.5%) **** NIAMS (33 = 1.7%) NIH average 0.5% * = > 2% (NIH average) in < 0.5% = NIDCD(4), NIGMS(21), NCI(32), OD(1), NIEHS(3), NCATS(3), NIMH(11), NIAID(11), NIA(5), NICHD(3), FIC(1), Regenerative Medicine NIAAA(0), NIDA(0), NLM(0), NIMHD(0), NINR(0), NCCAM(0)

Sample IC Mission Statements integrating the physical and engineering sciences with the NIBIB life sciences to advance basic research and medical care improve oral, dental and craniofacial health through NIDCR research, training, and dissemination of health information support research into the causes, treatment, and NIAMS prevention of arthritis and musculoskeletal and skin diseases, training of basic and clinical scientists for this global leadership for a research, training, and education NHLBI program to promote the prevention and treatment of heart, lung, and blood diseases medical research, training and dissemination of science- NIDDK based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases

 What New in the Zoo − NIBIB

There are two kinds of scientific revolutions, those driven by new tools and those driven by new concepts… The effect of a concept - driven revolution is to explain old things in new ways. The effect of a tool-driven revolution is to discover new things that have to be explained. -Freeman Dyson, 1997

the NIBIB distinction… • Technology development • Enabling tools/approaches Featured Mechanisms  Bioengineering grants (EBRG, BRG, BRP)  Biomedical Technology Resource Centers (P41)  Quantum grants Featured Programs  Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS)  Multiscale Modeling Consortium  Point-of-Care Technologies Research Network It’s not enough to be UNIQUE… you must also be USEFUL.

Creating Biomedical Technologies to Improve Health Scientific Program Areas • Biomaterials • Micro-Biomechanics • Biomedical Informatics • Micro-/Nanosystems & Platforms • Delivery Systems & Devices for Drugs • Molecular Imaging and Biologics • Nuclear Medicine • Image-Guided Interventions • Optical Imaging and Spectroscopy • Image Processing, Visual Perception and • Rehabilitation Engineering Display • Integration of Implantable Medical • Sensors Devices • Surgical Tools, Techniques & Systems • Magnetic, Biomagnetic and Bioelectric • Synthetic Biology for Technology Development Devices • Telehealth • Magnetic Resonance Imaging and • Tissue Engineering Spectroscopy • Ultrasound: Diagnostic & Interventional • Mathematical Modeling, Simulation and • X-ray, Electron, and Ion Beam Analysis

NIH Bioengineering Program Announcements  PA-12-284: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21) early and conceptual stages of new exploratory and developmental research that may involve considerable risk but may lead to a breakthrough  PA-13-137: Bioengineering Research Grants (BRG) (R01) integrated, systems approach to basic and applied multi- disciplinary research that addresses important biological, clinical or biomedical research problems  PAR-14-092: Bioengineering Research Partnerships (BRP) (R01) team approach to basic, applied, and translational multi- disciplinary research to establish a robust engineering solution to a biomedical problem

BioTechnology Resource Centers (P41)  Strong foundation of Technology Research & Development (TR&D) Projects − national/international impact − innovative, cutting-edge complex, multidisciplinary − − high-risk test beds leading to practical tools  Driven by needs of the field through robust Collaborative Projects (CP) dynamic, push-pull relationships −  Deploying results via Service Projects (SP) − geographically diverse technology push − − exploit more mature capabilities of the Center  Committed to training practitioners  Aggressive dissemination – research papers, reviews CP – patents SP SP CP CP CP CP – presentations, workshops CP SP SP SP CP – website(s) SP  Seamless Oversight TR&D TR&D TR&D CP project project project – senior scientist to “herd cats” – experienced TR&D Leaders A D M I N I S T R A T I O N – Scientific Advisory Board P41 Components & Structure – institutional Support

NIBIB’s Quantum Grants: Medical Moonshots (PAR-15-031)  profound impact  prevent/diagnose/treat a major disease  technology development  12 years (4 year grant, twice renewable)  deliverable-focused, milestone-driven  $1M direct costs per year  due dates: January 26, 2016 and 2017 Current projects:  Point-of-care Microfluidics for Early Detection of Cancer (Mehmet Toner)  Influenza vaccine using a microneedle patch (Mark Prausnitz)  Optimizing Cardiovascular Device Thromboresistance for Eliminating Anticoagulants (Danny Bluestein)  Neurovascular Regeneration (Karen Hirschi)  Building an Implantable Artificial Kidney (Shuvo Roy)  One Stop Shop Imaging for Acute Ischemic Stroke Treatment (Guang-Hong Chen)