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DHL Solutions & Innovations Temperature monitoring of non Temperature monitoring of non- actively cooled pharmaceutical actively cooled pharmaceutical transportation transportation A Amir Mousavi i M i September 2010, Bonn Agenda


  1. DHL Solutions & Innovations Temperature monitoring of non Temperature monitoring of non- actively cooled pharmaceutical actively cooled pharmaceutical transportation transportation A Amir Mousavi i M i September 2010, Bonn

  2. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 2

  3. Status temperature controlled shipments in Germany Market situation  Increasing temperature controlled shipment capacity I i t t t ll d hi t it  Increasing volume of temperature sensitive goods e.g. life sciences and pharmaceutical products, chemicals and food e g e sc e ces a d p a aceut ca p oducts, c e ca s a d ood Cargo load Swap bodies ntity > 10 t Quan Temperature ranges 5 – 10 t 2 – 5 t  frozen : < - 20 °C < 2 t  chilled: + 2 °C to + 8 °C  ambient: +15 °C to + 25 °C Year Year Status of temperature controlled transports in Germany Source: Federal Office for Motor Traffic (Kraftfahrt Bundesamt) 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 3

  4. Status temperature controlled shipments DHL DHL cold chain services  Temperature controlled transportations Temperature controlled transportations  FTL / LTL services  Partially temperature monitoring vehicles  End-to-end temperature monitoring very difficult to realize  87 % are ambient shipments DHL SmartSensor temperature service  focuses on end-to-end temperature monitoring focuses on end to end temperature monitoring  intelligent temperature sensor  RFID interface  Temperature monitoring on all levels of transportation 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 4

  5. Temperature monitoring approaches Observed monitoring approaches  For frozen and chilled products temperature monitoring usually takes place on For frozen and chilled products temperature monitoring usually takes place on shipment level  For ambient products temperature monitoring takes place on shipment, pallet, swap body or container level b d t i l l  Ambient transportations are mostly not shipped with temperature controlled vehicles  In cases one sensor is linked to all shipments in a swap body  Temperature data not evaluated on swap body level 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 5

  6. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 6

  7. Scope Questions  How many sensors are necessary to allocate the temperature in a swap body and conclude the whole environment temperature?  Which relation is given between number of sensors and the quality of g q y monitored temperature? Subject of analysis and Measuring device: DHL SmartSensor Temperature DIN EN 284:2006 Swap body 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 7

  8. DHL SMART SENSOR TEMPERATURE DHL SST in a glance Sensor Sensor Reading device Reading device Web portal Web portal Wireless Wireless Data logging Data read-out Data analysis  …is an end-to-end monitoring solution developed by DHL Target Market  …offers transportation & temperature monitoring from one single source  Life Sciences  …uses future-proof technologies  Food and other perishables  …is delivered ready-to-go  Chemicals  … no change to your existing IT-system necessary   …enables automated data distribution enables automated data distribution External Partners  …provides 24/7 data availability , worldwide  … shelf life algorithms implemented 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 8

  9. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 9

  10. Methodology Challenges for temperature monitoring of ambient products transported in swap bodies  high cost for temperature monitoring on shipment level  high cost for data harvesting and management  difficulty of placement of sensors Conflict of objectives Conflict of objectives Minimal numbers Highest quality of of sensors temperature data  Reason of conflict of objectives: Lack of information 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 10

  11. Methodology Approach  Solving the lack of information via interpolation of temperature data S l i th l k f i f ti i i t l ti f t t d t  Reducing the cost through replacing hardware sensors by software sensors Method  Adaption of the geo-statistical Kriging method  Pro: P  Statistical interpolation method  Usage of variography to optimize the results Usage of variography to optimize the results  Able to solve 3D problems  Best linear unbiased estimator (BLUE)  Contra:  Requests high quality of data  Complexity in calculations Complexity in calculations 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 11

  12. Methodology Experimental a nd theoretical variograms*: Experimental variogram: Experimental variogram: - from measured data - Scatter plot p Theoretical variogram: - Exponential variogram function Exponential variogram function - Method of smallest squares * The variogram is a location-independent method which indicates the mean statistical spread g p p of the differences between two random variables through the vector h and is the degree of the spatial relation between these two variables. 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 12

  13. Methodology Gathering of temperature allocation  63 sensors for temperature data harvesting 63 sensors for temperature data harvesting  in a 3x3x7 matrix alignment  24 hours measuring duration for each test g  14 minutes measuring intervals DHL Swap body SmartSensor Z 7300 mm X 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 13

  14. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 14

  15. Results of temperature gathering 1/2 Mean temperature in the swap body Measurement of 09.09. Measurement of 22.09. C ure in ° C emperatu Mean te time 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 15

  16. Results of temperature gathering 2/2 Mean temperature of swap body outer walls 09.09. – 10.09. C ure in ° C emperatu Mean te ti time left right roof floor door rear 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 16

  17. Relation between no. of sensors and mean interpolation lapse Optimization of measuring network according to max error- and Kriging-Variance ° C Error in ° no of sensors no of sensors max. error mean error max. error mean error (Error) (Error) (variance) (variance) 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 17

  18. Verification Interpolation: Measurement of 22.09.2010 with 14 sensors Interpolation error Interpolation error ° C time time mean error max error defined mean error 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 18

  19. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 19

  20. Summary Temperature situation in the swap body  Temperature allocation at daytime not constant  over daytime high temperature differences through the spatial dimensions  very homogenous temperature allocation from evening time h t t ll ti f i ti  Temperature differences for loaded swap body must be considered Temperature monitoring with lowest numbers of sensors  Kriging-method to eliminate information lapse  Optimization of measuring network according to the maximum interpolation error delivers good results  Defined mean interpolation error is only excided very shortly Defined mean interpolation error is only excided very shortly  Results under the given sensor tolerance of ± 0,5°C 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 20

  21. Agenda Introduction Scope Methodology Results Summary Summary Forecast 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 21

  22. Forecast Methodology enhancements based on results  Further analysis of the Kriging- method y g g  Analysis of different load situations in swap bodies Technological enhancements  Analysis of further condition parameter e.g. humidity and shock  More detailed and longer observation of monitoring M d t il d d l b ti f it i  Risk of increasing technology costs  Mathematical methods can be used to reduce technology costs 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page 22

  23. Thank you for your attention! Thank you for your attention! Time for questions Time for questions 4th International Workshop - Cold Chain Management | Bonn | September 2010 DHL | Page

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