Stephen Lagakos and the New England Statistical Consulting at NEJM : 1997 ‐ 2009 Journal of Medicine Gregory Curfman, M.D. Executive Editor, New England Journal of Medicine
Statistical Consulting at NEJM : 1997 ‐ 2009
Statistical Consulting at NEJM : 1997 ‐ 2009
Statistical Consulting at NEJM : 1997 ‐ 2009
1812: The New England Journal of Medicine and Surgery, and the Collateral Branches of Science established. 1823: The Medical Intelligencer established. 1828: The two journals merged into the weekly Boston Medical and Surgical Journal. 1928: The journal adopted its current name, The New England Journal of Medicine.
John Collins Warren, M.D. Editor ‐ in ‐ Chief
Yearly submissions: 6,646 Acceptance rate: 6% Research articles: 225 published/year Readers: 600,000/weekly issue Current impact factor: 47.05 Articles on: • Clinical Medicine • Translational Medicine • Health Policy
History of Statistical Consulting at NEJM Statistical Consulting at NEJM : 1997 ‐ 2009 1979 Lawrence Thibodeau becomes the first statistical consultant. (1 consultant) 1980 John Bailar replaces Thibodeau. (1 consultant) 1987 Walter Willett joins Bailar. (2 consultants) 1991 Bailar leaves. Frederick Mosteller and James Ware are hired. (3 consultants) 1992 Mosteller leaves. Alexander Walker is hired, and The W’s form. (3 consultants)
Who Are the W’s? Statistical Consulting at NEJM : 1997 ‐ 2009 Walter Willett, MD James Ware, PhD Alexander Walker, MD
History of Statistical Consulting at NEJM Statistical Consulting at NEJM : 1997 ‐ 2009 1996 Walker leaves. (2 consultants) 1997 Stephen Lagakos is hired. (3 consultants) 2000 David Hunter is hired. (4 consultants) 2001 Willett leaves. (3 consultants) 2007 Ralph D’Agostino is hired. (4 consultants) 2010 David Harrington is hired. (4 consultants)
Statistical Consulting Process • Articles with statistical content reviewed at initial submission. • Most revised articles reviewed a second time. • For clinical trials: review of protocol and clinicaltrials.gov. • Review requires 1.5 hours on average.
Statistician’s Role: Comprehensive Review • Study design: assess appropriateness. • Study conduct: assess aspects that have implications for the validity of study and strength of findings. • Data analysis: assess appropriateness and validity, review for consistency with protocol. • Conclusions: assess validity of conclusions reached by investigators.
Contributions of Dr. Lagakos to NEJM Statistical Consulting at NEJM : 1997 ‐ 2009 Statistical Consultant • Statistics in Medicine • Research •
Statistical Consultant at NEJM , 1997 ‐ 2009 Statistical Consulting at NEJM : 1997 ‐ 2009
Work Product 740 published manuscripts reviewed • Approximately 60 published manuscripts • per year More than 1 article per weekly issue •
Contributions in Infectious Disease • Antiretroviral therapy: defining surrogates • Mother ‐ to ‐ child transmission of HIV • New antiinfective drugs • Vaccines: HIV, malaria, HPV
Statistical Consulting at NEJM : 1997 ‐ 2009
Statistics and Medicine Statistical Consulting at NEJM : 1997 ‐ 2009
Statistics and Medicine Statistical Consulting at NEJM : 1997 ‐ 2009
Research : Zidovudine Statistical Consulting at NEJM : 1997 ‐ 2009
Research : HIV/AIDS Statistical Consulting at NEJM : 1997 ‐ 2009
Commentary : HIV/AIDS Statistical Consulting at NEJM : 1997 ‐ 2009
Commentary : HIV/AIDS Statistical Consulting at NEJM : 1997 ‐ 2009
Statistical Consultant at NEJM , 1997 ‐ 2009 Statistical Consulting at NEJM : 1997 ‐ 2009
Statistical Consulting at NEJM : 1997 ‐ 2009 Stephen Lagakos 1946 ‐ 2009
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