Smoking and Risk of Childhood B- -cell ALL cell ALL Smoking and - PowerPoint PPT Presentation

Smoking and Risk of Childhood B- -cell ALL cell ALL Smoking and Risk of Childhood B 756 cases- -1226 controls 1226 controls 756 cases Active Timing Exposed Exposed OR 95% CI Active Timing Exposed Exposed OR 95% CI Smoker Cases Controls Smoker Cases Controls Father 1 Father Pre- Pre -conception (yes/no) conception (yes/no) 200 200 273 273 1.19 1.19 0.95- 0.95 -1.48 1.48 (#CPD) --- --- 1.02* 1.00- -1.03 1.03 (#CPD) --- --- 1.02* 1.00 Mother 2 Pre- -conception (yes/no) conception (yes/no) 102 149 0.67 0.39- -1.15 1.15 Mother Pre 102 149 0.67 0.39 (#CPD) --- --- 1.02 0.98- -1.07 1.07 (#CPD) --- --- 1.02 0.98 Pregnancy (yes/no) Pregnancy (yes/no) 72 72 97 97 1.21 1.21 0.71- 0.71 -2.07 2.07 (#CPD) (#CPD) --- --- --- --- 0.97 0.97 0.91- 0.91 -1.04 1.04 Any 3 After birth (yes/no) 174 205 1.29* 1.02- -1.64 1.64 Any After birth (yes/no) 174 205 1.29* 1.02 CPD: Cigarettes Per Day; ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income. 1 n=691 ALL due to delay in collecting data; 2 OR adjusted for postnatal maternal smoking and birth weight; 3 Include mother, father, or others. � No increased risk observed for T-cell ALL (n=76) 1

Results by Major Cytogenetic Subtype of Childhood B-cell ALL t(12:21) Hyperdiploidy t(12:21) Hyperdiploidy n=133 n=133 n=228 n=228 Smoker Smoker Timing Timing OR OR 95% CI 95% CI OR OR 95% CI 95% CI Father 1 Father Pre- Pre -conception (yes/no) conception (yes/no) 1.41 1.41 0.92- 0.92 -2.16 2.16 0.94 0.94 0.66- 0.66 -1.34 1.34 (#CPD) 1.03* 1.01- -1.06 1.06 1.00 0.98- -1.03 1.03 (#CPD) 1.03* 1.01 1.00 0.98 Mother 2 Pre- -conception (yes/no) conception (yes/no) 0.63 0.23- -1.77 1.77 0.69 0.30- -1.57 1.57 Mother Pre 0.63 0.23 0.69 0.30 (#CPD) 1.00 0.91- -1.11 1.11 1.04 0.98- -1.10 1.10 (#CPD) 1.00 0.91 1.04 0.98 Pregnancy (yes/no) Pregnancy (yes/no) 1.54 1.54 0.60- 0.60 -3.93 3.93 1.09 1.09 0.47- 0.47 -2.51 2.51 (#CPD) (#CPD) 0.95 0.95 0.85- 0.85 -1.05 1.05 0.96 0.96 0.87- 0.87 -1.06 1.06 Any 3 After birth (yes/no) 1.96* 1.28- -3.00 3.00 0.97 0.66- -1.42 1.42 Any After birth (yes/no) 1.96* 1.28 0.97 0.66 CPD: Cigarettes Per Day; ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income. 1 Delay in collecting data; 2 OR adjusted for postnatal maternal smoking and birth weight; 3 Include mother, father, or others. 2

Joint E ffect of Smoking on Risk of B- -cell ALL cell ALL Joint E ffect of Smoking on Risk of B Smoking exposure Father Any smoker, preconception after birth Cases/Controls OR* (95% CI) No No 443/830 Reference No Yes 93/160 0.96 (0.72-1.28) Yes No 44/88 0.84 (0.57-1.23) Yes Yes 103/109 1.45 (1.07-1.97)** * ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income; **P-value for interaction=0.017 � Same observation for B-Cell ALL with t(12;21) 3

Child’ ’s Passive Smoking and s Passive Smoking and Child Risk of Childhood AML Risk of Childhood AML Exposed Exposed OR 95% CI Exposed Exposed OR 95% CI Cases Controls Cases Controls AML, total (n=145) 42 205 1.49 0.98- -2.26 2.26 AML, total (n=145) 42 205 1.49 0.98 ” 1 1 (n=40) AML, “ “good prognosis good prognosis” (n=40) 14 205 1.94 0.94- -3.99 3.99 AML, 14 205 1.94 0.94 AML, other cytogenetic changes (n=75) 20 205 1.24 0.70- -2.19 2.19 AML, other cytogenetic changes (n=75) 20 205 1.24 0.70 ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income. 1 Any translocation involving chromosome 21, t(15;17) or inversion Any translocation involving chromosome 21, t(15;17) or inversion (16) (16) 4