Previous Involvement With China 1983-4 Guangzhou: project on leishmaniasis 1987- Xinjiang: set up and participated in multi- disciplinary project on hydatid disease. Developed new formulation for albendazole which is now used in clinic 1993 Lectured in Guilin on snake venom vaccines 2002/3 Part of two UK government delegations to China on biotechnology
helping the biotech industry achieve its full potential Oral vaccine carriers Oral delivery of peptides and A revolutionary new proteins method of drug discovery
Present Involvement Set up and use facility in China to conduct large-animal preclinical studies for pharmaceutical development
Pig Model for Studying Intestinal Pig Model for Studying Intestinal Absorption of Peptides Absorption of Peptides Single capsule administered to pig (40-60 kg) via indwelling stoma in jejunum. Blood samples taken at intervals thereafter.
Delivery of Insulin via the Oral Route Delivery of Insulin via the Oral Route Effect of unformulated insulin (200iu) on plasma glucose levels 1 2 3 4 0 Time in hours 0 1 2 3 4 -2.5 -2.5 Fall in plasma -5 glucose (mmol/L) Effect on plasma glucose levels of insulin (200iu) in oral delivery vehicle (capsule) -5
Current Status Work done in China has laid basis for formulations such as Proxima’s oral insulin to proceed to phase II human clinical trials, and is ready to go to phase III Advantages to small biotech: Less bureaucracy Less cost More flexibility
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