October 18, 2017 1 / 19 converging trends Lytton UW N GR Oct 18, - PowerPoint PPT Presentation

October 18, 2017 1 / 19

converging trends Lytton UW N GR Oct 18, 2017 2 / 19

Climbing the omes omeomics genomes (microbiome, tumorome, virome) epigenomes (MS?) proteome (organ-specific), interactome, metabolome physiome connectome (in neuro) etceterome Lytton UW N GR Oct 18, 2017 3 / 19

6 drunk blind men looking for keys on an elephant riding on an iceberg Lytton UW N GR Oct 18, 2017 4 / 19

Multiscale modeling scales of investigation Lytton UW N GR Oct 18, 2017 5 / 19

Dynamical disorders dynamics of variability in degenerative disorders epilepsy migraine Alzheimer? Parkinson dystonia Lytton UW N GR Oct 18, 2017 6 / 19

River of epilepsy modified from Lennox&Lennox Lytton WW. Computer modelling of epilepsy Nat Rev Neurosci 2008 Lytton UW N GR Oct 18, 2017 7 / 19

Two pathways out of M1 collaboration with Gordon WG Shepherd, Northwestern Lytton UW N GR Oct 18, 2017 8 / 19

Detailed modeling of major cell types of Layer 5 PT==SPI Lytton UW N GR Oct 18, 2017 9 / 19

Schematizing neocortex NB: mouse M1 has a layer 4 Lytton UW N GR Oct 18, 2017 10 / 19

Working out drug cocktails motor cortex (M1) model Lytton UW N GR Oct 18, 2017 11 / 19

Complex patterns of activity stim lower layers Lytton UW N GR Oct 18, 2017 12 / 19

Lytton UW N GR Oct 18, 2017 13 / 19

Interpose a virtual arm Matching carrier as well as signal? virtual arm courtesy Xianlian Zhou & Andrzej Przekwas, CFD Research Corp, Huntsville, AL Lytton UW N GR Oct 18, 2017 14 / 19

Robot follows virtual arm Lytton UW N GR Oct 18, 2017 15 / 19

Reinforcement learning (RL) Lytton UW N GR Oct 18, 2017 16 / 19

RL alters STDP effect Lytton UW N GR Oct 18, 2017 17 / 19

Feedback from muscle lengths and forces Lytton UW N GR Oct 18, 2017 18 / 19

Lytton UW N GR Oct 18, 2017 19 / 19