Tackling AMR – Developing new ways of working Dr Ghada Zoubiane Medical Research Council - UK AMR intergovernmental workshop - November 2015
The UK: A rich network of funders and researchers UK Government Departments OSCHR Research community InnovateUK Research Learned societies Councils Parliamentarians Policy-makers NIHR Public Industry Defra/VMD Universities International Medical charities Patients and carers NHS
UK 5 year AMR Strategy • DH and DEFRA: 2013 -2018 • Seven key areas of action Improving infection prevention and control practices Optimising prescribing practice, stewardship Improving professional education, training and public engagement Developing new drugs, treatments and diagnostics Better access to and use of surveillance data Better identification and prioritisation of AMR research needs Strengthened international collaboration
UK spend on AMR (2007-2013) Total funding: £275m (<1% research budget) £0.49m £21.7m Therapeutics £16.6m Diagnostics £16.8m Underpinning Surveillance Alternatives Optimisation Transmission Lead compounds £163m £56m Environment Interventions
What is needed? • Collaborative working • Coordination of key disciplines • Coordinating research funding – government and other research funders including industry • Ensuring integration with human/animal healthcare UK AMR Funders’ Forum
AMR Funders’ Forum (AMRFF) • Made up of representatives from the research councils, governmental bodies and charities • Led and managed by the MRC • Has a common vision for AMR research and its implementation • Will add value to existing programmes • Will coordinate and/or support the initiation of funding and delivery programmes • Will raise the profile of the AMR research base in the UK and internationally
AMRFF current membership • The Arts and Humanities • The Food Standards Agency (FSA) Research Councils (AHRC) • HSC R&D Division, Public Health • The Biotechnology and Biological Agency, Northern Ireland Sciences Research Council • Innovate UK (BBSRC) • *The Medical Research Council • Defra, the Veterinary Medicines (MRC) Directorate • National Institute of Health • Department for International Research (NIHR) Development (DFID) • The Natural Environment • The Department of Health Research Council (NERC) • Defence Science and Technology • Public Health England Laboratory (Dstl) • The Science and Technology • The Economic and Social Facilities Research Council (STFC) Research Council (ESRC) • The Wellcome Trust • The Engineering and Physical • The Welsh Government Sciences Research Council (EPSRC)
UK Research Councils • The research councils: broad remits; support AMR across the whole of the research spectrum Research Councils portfolio: ~£25m per year on AMR
AMR Cross-council Initiative • Launched June 2014 • All Research Councils – led by MRC • Bacterial resistance in the first instance • 4 themes to tackle AMR
Steering Group Herman Goossens (Chair) – University of Antwerp, Belgium Sharon Peacock – University of Cambridge/Bloomsbury Institute, UK Duncan Maskell – University of Cambridge, UK Rachel McKendry – University College London, UK Richard Smith- London School of Hygiene and Tropical Medicine, UK Elizabeth Wellington – Warwick University, UK David Payne – GlaxoSmithKline Jared Silverman – VL32 (Ex-Cubist pharmaceuticals)
Antimicrobial Resistance – a thematic approach Understanding resistant bacteria Accelerating therapeutic and diagnostic development Understanding real world interactions Behaviour within an beyond the health care setting
Funding • Multidisciplinary research • Themed calls • Mixed funding models • Kick start with £36m • Scalable approach • Networking preceding final submissions • Priority at next CSR
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