Company Cooperation Products &Services Marketing Financials New Developments at Axiogenesis 09.06.2016 Hamamatsu User Meeting Dr. Ralf Kettenhofen Barcelona, Spain •Presented for:
Company Characterization Product/Format Service Content Optogentics Contraction Force - The Cor.4CE System Matured Cor.4U Cardiomyocytes •Presented for: 2
Company Cooperation Products &Services Marketing Financials Optogenetics Encoded Calcium Sensors •Presented for:
Company Characterization Product/Format Service Baculovirus Transduced Gene Delivery and the Fluorescent Sensor •Presented for: 4
Company Characterization Product/Format Service Baculovirus Transduced Cor.4U Cardiomyocytes - Fluorescent Microscopy 50x 3d after transduction •Presented for: 5
Company Characterization Product/Format Service First Recordings in the FDSS 7000EX 3d after transduction Isoproterenol 1600 100 90 1400 80 1200 beat rate [bpm] amplitude [FU] 70 1000 60 Baseline 800 Baseline 50 40 600 5 min 5 min 30 400 10 min 10 min 20 200 20 min 10 20 min 0 0 Vehicle 1.0 10 30 100 Vehicle 1.0 10 30 100 Control Control concentra.on [nM] concentra3on [nM] •Presented for: 6
Company Characterization Product/Format Service Encoded Calcium Sensor Modified Cor.4U Cardiomyocytes Quality control of cells before start of assay. Long-term recording and study of chronic toxicity in Cor.4U cardiomyocytes become possible in the FDSS => Requirements are: Measurement in the FDSS under sterile conditions (with lid) Cell culture condition in the FDSS (CO 2 + humidity) or attachment to a cell hotel Automated repeated recording (e.g. over night) Higher throughput (parallelization): bar code reader and automated recording •Presented for: 7
Company Characterisation Applications Services Formats Cor.4CE Cor.4U and FibroCor.4U Co-Culture •
Company Characterisation Applications Services Formats The CellDrum System p: Pressure h: Deflection r: Radius s: Thickness • 9
Company Characterisation Applications Services Formats The CellDrum System a: Amplitude b1, b2: Slopes d1, d2: Integrals c1, c2: Durations • 10
Company Characterisation Applications Services Formats The New 24 Well CellDrum System Top view Bottom view • 11
Company Cooperation Products &Services Marketing Financials Matured Cor.4U Cardiomyocytes •Presented for:
Matured Cor.4U Cardiomyocytes 6 weeks culture on a non-stiff cell culture surface •Presented for: 13
Company Characterization Product/Format Service Matured Cor.4U Cardiomyocytes cardiac alpha actinic nuclei •Presented for: 14
Thank you! www.axiogenesis.com Axiogenesis AG info@axiogenesis.com Nattermannallee 1 order@axiogenesis.com 50829 Cologne Germany tel: +49 221 99 88 18 - 0 fax: +49 221 9988 18 -10 • 15
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