NEGLECTED DISEASE RESEARCH & DEVELOPMENT: THE PUBLIC DIVIDE - PowerPoint PPT Presentation

NEGLECTED DISEASE RESEARCH & DEVELOPMENT: THE PUBLIC DIVIDE

Policy Cures Innovative ideas and accurate analysis to accelerate development and uptake of new drugs, vaccines, diagnostics and other products for neglected diseases of the developing world

G-FINDER OVERVIEW • Annual survey of global investment into R&D of new neglected disease products • Neutral, comparable, comprehensive analysis • Commissioned by the Bill & Melinda Gates Foundation

G-FINDER SCOPE & METHODOLOGY • 31 neglected diseases • 134 product areas • All R&D stages • Data from 201 organisations • Over 9,000 entries

Findings OVERALL $3,165m invested into R&D for new neglected disease products in 2012

Findings OVERALL $92.1m higher in 2012 than in 2011 $3.0bn n $3.0bn bn $2.9bn bn $2.9bn n $2.8bn bn $2.4bn bn 2007 20 07 20 2008 08 20 2009 09 20 2010 10 20 2011 11 20 2012 12

Findings DISEASES $3,000 $3 00 10 100 ding ons ($) % of funding 90 90 lion Top tier diseases Milli $2,500 $2 00 80 80 HIV/AIDS ( ↑ $37.8m) 70 70 $2,000 $2 00 TB ( ↓ $32.5m) 60 60 Malaria ( ↓ $22.3m) $1 $1,500 00 50 50 40 40 $1 $1,000 00 30 30 20 20 $500 $5 00 10 10 $0 $0 0 2007 2008^ 2009^ 2010^ 2011^ 2012^

Findings DISEASES $3,000 $3 00 100 10 Second tier diseases ding ons ($) % of funding Dengue ( ↑ $17.7m) 90 90 lion Milli $2,500 $2 00 80 80 Salmonella infections ( ↑ $6.7m) 70 70 $2 $2,000 00 Helminth infections ( ↑ $5.1m) 60 60 $1 $1,500 00 50 50 Diseases with stable funding: 40 40 Diarrhoeal diseases $1 $1,000 00 30 30 Bacterial pneumonia & meningitis 20 20 $500 $5 00 Kinetoplastids 10 10 $0 $0 0 2007 2008^ 2009^ 2010^ 2011^ 2012^

Findings DISEASES $3,000 $3 00 100 10 ding ons ($) % of funding Third tier diseases 90 90 lion Leprosy ( ↑ $6.1m) Milli $2,500 $2 00 80 80 70 70 Diseases with stable funding: $2,000 $2 00 Trachoma 60 60 $1,500 $1 00 50 50 Rheumatic fever 40 40 Buruli ulcer $1 $1,000 00 30 30 20 20 $500 $5 00 10 10 $0 $0 0 2007 2008^ 2009^ 2010^ 2011^ 2012^

Findings FUNDERS Private te $527.2m 2m $51.9m $27.8m Phila lanth nthrop ropic ic $12.4m Public ic $631.0m .0m $2.0b 0bn Pri rivate te Phila ilanthr nthropic ic Pub ublic lic All sectors increased funding in 2012

Findings PUBLIC FUNDING $2 $2,050 50 ons lion $2,000 $2 00 Milli $1,950 $1 50 $1,900 $1 00 $24.8m $1 $1,850 50 $1,800 $1 00 $1,750 $1 50 $9.3m 3m $1,700 $1 00 $1,650 $1 50 Multi ltilat latera rals ls $1,600 $1 00 $1,550 $1 50 -$6.4m 4m 20 2007 07 20 2008 08 2009 20 09 2010 20 10 2011 20 11 20 2012 12 Public funding up $ 27.8m … (but more later )

Findings PHILANTHROPIC FUNDING Philanthropic funding up $51.9m $8 $800 00 ons lion Milli $7 $700 00 Entirely due to the Wellcome Trust (up $6 $600 00 $53.0m) $5 $500 00 $400 $4 00 $300 $3 00 $200 $2 00 $100 $1 00 $0 $0 2007 20 07 20 2008 08 2009 20 09 20 2010 10 20 2011 11 20 2012 12

Findings INDUSTRY FUNDING $600 $6 00 ns lions Milli $500 $5 00 $400 $4 00 Industry funding up $12.4m $300 $3 00 $200 $2 00 $100 $1 00 $0 $0 20 2007 07 20 2008 08 20 2009 09 20 2010 10 20 2011 11 20 2012 12 Indu ndustry try MNCs MNCs SMEs MEs

Findings TOP FUNDERS Funde der 2012 12 US$ $ 2012 12 percen centage tage of total l (%) %) (milli llions) s) US NIH 1,278.2 40.4 Aggregate industry 527.2 16.7 Gates Foundation 444.1 14.0 Wellcome Trust 147.8 4.7 European Commission 93.1 2.9 USAID 82.2 2.6 US DOD 74.8 2.4 UK MRC 47.7 1.5 UK DFID 45.4 1.4 Inserm 39.9 1.3 Australian NHMRC 29.4 0.9 Institut Pasteur 22.3 0.7 Subtotal top 12 funders 2,832.1 89.5

Findings PDP FUNDING $104.7m 7m The biggest decrease yet in PDP funding – down $87.4m (-20%) 2009 2009 2010 2010 2011 2011 2012 2012 -$34.7m 7m -$37.3m 3m -$38.2m 2m -$87.4m .4m

Discussion lions) llions) $5 $500 00 $1,500 (millions (millions ding ng lic funding ding Public pullback from $4 $450 50 US HIC public fundi $1,450 US public neglected disease R&D $400 $4 00 $1,400 $3 $350 50 funding 50% $1,350 Non-US $3 $300 00 Non $2 $250 50 $1,300 20% (ex-US) since $200 $2 00 $1,250 financial crisis $150 $1 50 $1,200 $1 $100 00 $1,150 $5 $50 $1,100 $0 $0 2007 2008^ 2009^ 2010^ 2011^ 2012^ US US HIC pub public lic fund unders rs (exc xclud luding ing US US)

Discussion 27.4% 4% Funding for product 50% development still declining Prod oduc uct t developm opment nt -1.8% 8% 2007-2012

Discussion PDP funding 2007-2012 $400 $4 00 ons lion Milli $350 $3 50 Every sector cut their PDP $3 $300 00 funding in 2012 $2 $250 50 Phila ilanthr nthropic ic Gates Foundat Gat Foundation ion $200 $2 00 Aid Ai d agenc gencie ies $150 $1 50 Scienc nce & & technol nology ogy agenc ncies ies $1 $100 00 $5 $50 $0 $0 20 2007 07 2008 20 08 20 2009 09 20 2010 10 20 2011 11 20 2012 12

The public divide • The public sector drives R&D funding (two- thirds) … what governments do matters • The US Government is holding the funding line – other governments are not • Growing gap between government funding for academic research and product development

Download the full report at www.policycures.org/g-finder2013.html