Medical Terminology Management in Evidence Synthesis: Early Versus Late Binding Craig Whittington, PhD, Sandra Zelman Lewis, PhD, Tobias Sayre, and Robert Battista, MBA
Disclosures All 3 of us are employed by Doctor Evidence . 2
Outline The context Ontology management Why late binding is superior How researchers can benefit 3
Doctor Evidence is a global technology and services company, providing dynamically-updatable systematic evidence reviews Digitizing evidence from published studies, clinical trials, meeting abstracts, and other forms of clinically-relevant data permits: • Sophisticated analytic capabilities – Direct (pairwise) meta-analyses – Network meta analyses (Bayesian, frequentist) – Cohort analyses • Graphical visualizations of a body of evidence • Easily customized evidence tables 4
Ontology Management One obstacle in evidence synthesis: primary research studies use various terminologies based on geography, therapeutic area, time, researcher, etc. CURRENT STANDARD PRACTICE OF DATA CAPTURE Involves Different These bindings Does not allow application of variables are not easily for transparent poorly-defined representing restorable review of authors' term ontologies, what are thought source language or arbitrary to be the same and context. decisions to construct are group terms often bound together using subjective and poorly-defined criteria 5
Ontology Management DOCTOR EVIDENCE’S APPROACH: Learning system based on previous bindings Terms can be unbound or rebound. Terms are bound after suggests options these extractions: selected before Term, taxonomy, “late - binding” and ontology As appropriate management for specific system literature analyses • preserving the original terms and definitions, • efficiently accommodating Enables data to be synonyms, and captured, stored, and • utilizing a variety of indexed "as is" in the medical ontologies literature 6
Advantages of Late Binding ADVANTAGES LATE BINDING 7
DEMO 8
Value to Healthcare Providers Healthcare providers can trust evidence reviews created with this term management approach VALUE TO HEALTHCARE PROVIDERS Thoughtful and Specificity is relevant term Clinical binding has been relevance has captured . incorporated into been the appropriate maintained. analyses. 9
Value to Researchers Healthcare providers can trust evidence reviews created with this term management approach VALUE TO RESEARCHERS High quality Granularity Ability to Filtered and Comparative of concepts data quickly bound reviews of extractions review outcomes & various preserving original variables, as ontologies or original terms and appropriate creation of terms and definitions in for each new definitions context analysis ontologies subgroup analysis 10
Contact Us for a Complete Demo Sandra Zelman Lewis, PhD Chief Guidelines Officer slewis@doctorevidence.com Craig Whittington, PhD Global Head of Quality, Methodology, and Innovations cwhittington@doctorevidence.com 11
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