Lenses Beyond Limits Jen Dionne, Stanford University
Event Horizon Telescope, 2019
Earthrise, William Anders, NASA
Co Rentmeester, 1984
Wilhelm Rontgen, 1985
The Inner Life of a Cell, XVIVO, Cellular Visions and Harvard
Tarun Narayan, Andrea Baldi, and Fariah Hayee 40 Narayan*, Hayee*, Baldi, Koh, Sinclair, Dionne, Nature Comm. (2017)
Ashwin Atre 50 nm Atre, Brenny, Coenen, Garcia-Etxarri, Polman, Dionne, Nature Nanotechnology (2015)
Force ( μN ) 1 10 Lay, Goodman, Dionne, Submitted (2019)
mirror plane DNA amino acid Sugar
limonene DNA thalidomide Treats morning nausea Induces birth defects
Approximately 50% of drugs and 40% of agrochemicals are chiral Of these, more than 90% are sold as mixtures of both enantiomers
Can we use light to separate enantiomers?
E B time
chiral nanospecimen nanocoaxial optical fiber Circularly polarized light
R-enantiomer L-enantiomer
L-enantiomer R-enantiomer Right circularly polarized light
Yang Zhao and Amr Saleh
2.5 Pulling force (pN) 0 Right circularly polarized light, 5 nanometer R-enantiomer Y Zhao & J. Dionne et al . ACS Photonics (2016)
2.5 Pulling force (pN) 0 Right circularly polarized light, 5 nanometer R-enantiomer Y Zhao & J. Dionne et al . ACS Photonics (2016)
2.5 Pulling force (pN) 0 Left circularly polarized light, 5 nanometer R-enantiomer
2.5 Pulling force (pN) 0 Left circularly polarized light, 5 nanometer R-enantiomer
1µm 5 µm
λ =770 nm 2 ) Force (pN/100 µ W/ µ m ) 60 pN Light on On orce ( 40 Laser ulling F 20 P Light off Off 0 5 10 15 20 T ime Time (s) Y. Zhao, A. Saleh, J. Dionne, et al., Nature Nanotechnology (2017)
6 Force (pN) 0 R-isomer L-isomer
80 RCP Force (pN/100 µ W/ µ m 2 ) 4 1 LCP Enantiomeric Excess (%) Lateral Force (pN) L-isomer 75 0 With filter R-isomer -6 No filter 70 0 100 0 100 40 40 60 80 100 Tip-aperture separation (nm) Yield (%) z (nm) Y. Zhao, A. Saleh, J. Dionne, et al., Nature Nanotechnology (2017) M. Solomon, J. Hu, J. Dionne, et al. ACS Photonics (2019)
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