Journey of SCAD Research Dr Abi Al-Hussaini Objectives Where we are - PowerPoint PPT Presentation

Journey of SCAD Research Dr Abi Al-Hussaini

Objectives • Where we are so far • Before the research day • On the day of research • After the research day • Preliminary Data • How can you help

Where we are so far 
 • 328 registrants to the SCAD website • 20 from Europe • 287 Online Questionnaire completed • New website to be launched • European Collaboration • 50 patients seen in research study

Before the research day 
 Registration to the SCAD UK website With interest in participating in research Thank you email and Link to the SCAD Questionnaire SCAD MAILBOX

Screening consent Medical data and Angiogram requested SCAD diagnosis verified Invitation for research Date

Confirmation email Travel Patient arrangement information sheet and Any consent form questions Research date

On the day Arrival Consent Imaging Flow Summary mediated of MRI diliation Clinical SWS Review MRI Questions CT Clinical Bloods for History & Biobankin Examinati g on Optional Skin Biopsy Retinal Imaging

Flow Mediated Dilation

Flow Mediated Dilation

Occlusion Cu fg release

Intimal Medial Thickness

MRI

CT

Biobanking

Skin Biopsy

Fibroblast cell culture

Retinal Photography

Clinical Phenotyping • History • Examination • Height and Arm Span • Wight and BP and HR • Examination of Joints and connective tissue

Following research day • Analysis of data • Generate Reports • Summary letter • Follow up Call • Clinic Follow up

Preliminary data • Heterogeneous Phenotype • Young • Peri/ Post partum • Perimenapausal • Men

Menstrual cycle

Hormonal changes

Hormonal changes in Menopause

Hormonal changes with Pregnancy

So far ……. • Most SCAD in the luteal phase • Perimenapause • Post partum • Suggests a hormonal aetiology • In men….. Not so clear

• Many patient with cyclical recurrent symptoms commonly in the luteal phase • Improvement of Symptoms with Mirena • Role of Diltiazem to help with symptoms • ? Aetiology may be Spasm

Imaging • CT cohort Healing of the dissection Seen as early as 4 weeks Aids clinical management

• Magnetic Resonance Angiogram Vascular abnormality Cardiac MRI No significant infarction, no significant damage Particularly in the conservative managed

Clinical • Heterogeneous population • Features of hypermobility • Most patient have many side e fg ects from medications • Post traumatic Stress, Depression and Anxiety • Recurrence rate

Development • Educate the Cardiology care service • Education of all medical professionals • Specialized Rehab program for your patients • Understanding the Psychological impact and provide support • Referrals

How can you help? • Registry • Questionnaire • Data retrieval • Research day • Contact us • Healthy volunteers

Thank you SCAD participants BRU sta fg AM Marsh Ellie Clark BRU nurses Jay Gracey K Green B Wreck K Cooper M Harrison E Beeston IT Support S Sterland R Bramley N Holden Dr Adlam Dr G Mccan Dr Will Adir Francesca Sinai Bart Wagner