3/8/2012 FURTHeR – Searching the University’s data resources for clinical cohorts LIFT Forum Joyce A. Mitchell, PhD Assoc Vice Pres Academic Health IT March 7, 2012 1 2 1
3/8/2012 Purpose • Support clinical and translational research • Join data from multiple sources for retrospective • Join data from multiple sources for retrospective studies • Current state: Support pre ‐ research questions for feasibility analysis – Return aggregate count information across data sources sources – Show unique and common patients across data sources • FURTHeR went live Nov 2011, so its new. Rationale – Cohort Finding • FURTHeR is focused on pre ‐ research cohort finding as its first effort • Nationally, 60% of RCTS fail or require an extension because of enrollment issues • At UU, of 726 clinical studies since 2007: – 25% met of exceeded stated recruitment goals – 75% failed to meet original stated recruitment • Some of these problems are difficulties with specifications of appropriate cohorts. 4 2
3/8/2012 The FURTHeR CTSA Mission Univ of Utah Clinical Hospitals & Clinics FURTHeR= Federated Utah Research & Translational R h & T l ti l Huntsman Health e-Repository Cancer Genotypic Institute Intermountain Phenotypic Healthcare Other VAMC Public health Partners Salt Lake City UDOH Genealogic FURTHeR Data Sources • UU EDW – Data back to 1994 – Demographics: >1.5M individuals – Lab Results: 94M records – Med Orders: 9.4M records Diagnoses: 17M records – Diagnoses: 17M records – Procedures: 346K records 6 3
3/8/2012 FURTHeR Data Sources • UPDBL – Demographics: >6.5M individuals – Diagnoses & Procedures : From 3.56M hospital claims • 1996 – present – Cause of Death (Death Certificates): 766K records • 1904 – present – Birth Certificates: 2.4M records • 1915 – 1921, 1943 – present p – Pedigree Quality: up to 11 generations – Master Subject Index • Links records from UU and Intermountain 7 Cohort statistics FURTHeR Record-level Pt. Data Genealogies UPDBL EDW(s) D M P L D E E R A I M M D D O O B A O C G G O E Idaho Utah Birth Inpatient R T N R D Cancer Cancer Certifi ‐ Idaho Hospital A E O Registry Registry cates D U Discharges P S S E R H T E Utah R E I Ambu ‐ Utah Idaho Death S S Voter C S S latory Drivers Cancer Certifi ‐ Registra ‐ Surgery License Registry cates tion 8 4
3/8/2012 January 2012 9 Total Faculty/Staff: 59 Total Students: 59 Total Registered Users: 118 FURTHeR Users Total Active Users: 79 Total Number of Queries: 604 February 2012 Medicine, MD Student Faculty/Staff School of Medicine College of Nursing College of Pharmacy Eccles Health Sciences Library Administration Huntsman Cancer Institute Pharmacy, PharmD Student Biomedical Informatics, PHD Student Nursing, MS Student Biomedical Informatics, MS Student Public Health, PHD Student 10 Clinical Investigations, MS Student 5
3/8/2012 FURTHeR Users (Feb 2012) more than 10 queries apiece • College of Nursing – 3 faculty, 2 MS students • College of Pharmacy – 3 faculty • College of Pharmacy – 3 faculty • Huntsman Institute – 1 research staff • School of Medicine – 20 faculty, staff, resident, stud – Rheumatology ‐ Genetic Epidemiology – Public Health ‐ Ophthalmology – Pathology ‐ Utah Cancer Registry – Pediatrics ‐ CARMA Center – Neurology ‐ Clinical Epidemiology – Psychiatry ‐ Biomedical Informatics 11 User Comments • This is a Game Changer. • This will cut 3 months off the front of my research project. • This will help me with recruitment by helping me identify new subjects on an ongoing basis. • I can identify a more appropriate set of • I can identify a more appropriate set of inclusion/exclusion criteria for my cohort before I submit my IRB. 12 6
3/8/2012 FURTHeR.utah.edu 13 FURTHeR User Agreement 7
3/8/2012 www.FURTHeR.Utah.edu 15 Example: GAD and IBS from UU EDW and UPDBL 8
3/8/2012 Example: Severe Pre ‐ eclampsia from UU EDW & UPDBL Example: Drug association with Diagnosis 9
3/8/2012 Example: Adding Lab Results and setting a value www.FURTHeR.Utah.edu Example – Diabetic Cataract Vs Diabetes and Cataract 20 10
3/8/2012 Diabetic Cataract 21 Diabetes and Cataract Example 22 11
3/8/2012 Example ‐ Glaucoma 23 Glaucoma Example 12
3/8/2012 Glaucoma and Sleep Apnea (building) Glaucoma Example (example 1) 13
3/8/2012 Glaucoma Example Glaucoma Example – demographics 1 14
3/8/2012 Glaucoma Example – demographics 2 Glaucoma Example – demographics 3 15
3/8/2012 Glaucoma Example – demographics 4 Glaucoma Example – demographics 5 16
3/8/2012 Example – Senile Macular Degeneration 33 Senile Macular Degeneration and Antihyperlipidemic Drugs 17
3/8/2012 Senile Macular Degeneration and Statins Senile Macular Degeneration and Statins 18
3/8/2012 What To Do Next? • Register for an account • Start querying q y g • Check out the FURTHeR Help Videos • Send email for assistance to further@utah.edu • Send me comments or questions – Joyce.mitchell@hsc.utah.edu • Use it!! It can help you with your research. Great News!! • Health Sciences Library to have FURTHeR mini ‐ courses i i – Monday, March 19 1 ‐ 3 pm – Wed, April 18 9 ‐ 11 am • Register on the HSL Home Page Be sure to Register on the HSL Home Page. Be sure to get your FURTHeR account authorized ahead of the class. 38 19
3/8/2012 FURTHeR Acknowledgements • FURTHeR Team • UU EDW Team – Rick Bradshaw, MS Ri k B d h MS • PPR/UPDB Team PPR/UPDB T – Dustin Schultz, MS • CHPC – Ryan Butcher – Andrew Iskander • Collaboration Partners – Ram Gouripeddi, MD – Intermountain – Gina Williams Gina Williams – SLC VAMC – Oren Livne, PhD – UDOH – Susan Matney, RN – Scott Narus, PhD 39 40 20
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