an update from the Global Burden of Disease Study Catherine O. - PowerPoint PPT Presentation

Global trends in cardiovascular disease - an update from the Global Burden of Disease Study Catherine O. Johnson, PhD MPH Lead Research Scientist, IHME Cardiovascular Group

Global Burden of Disease • Captures all forms of health loss (death, sickness, injury) • Covers all potential diseases, injuries, and impairments • Generates comprehensive and comparable estimates • Facilitates comparisons between different types of health loss

Over 20 years of innovation on GBD 2007: IHME 2018: IHME 1991: GBD 1993: Prelim. 2015: WHO 2016: IHME 1996-7: established and WHO originated results and IHME begins Final to catalyze sign new by the World published in sign MOU; annual results new era of MOU to Bank and World European updates to published GBD strengthen WHO Development BoD Network GBD as innovation GBD efforts Report formed global and uptake public good 1990 2000 2010 Today Publication of updated GBD results

GBD is a global effort 3,641 collaborators 143 countries 2 territories 4

Four “Building Blocks” of Estimation Causes of Death All-cause Mortality “How many people died?” “What do they die from?” YLLs, DALYs, YLDs, HALE Risk Factors Non-Fatal Outcomes “What’s causing this death and sickness?” “What makes people sick?”

Building Blocks : Cause of Death Causes of Death • Estimation of specific causes of death by All-cause Mortality age & sex . • Estimates then fit to all-cause mortality estimates. • Cause list is mutually exclusive and collectively exhaustive. • Important for informing health policy and interventions. YLLs, DALYs, YLDs, HALE Risk Factors Non-Fatal Outcomes

ICD: Cause Map • The cause list is mapped to ICD codes • Each cause is mapped to one or many ICD codes • Many iterations of ICD codes, such as ICD-9, ICD-9 BTL, ICD-10 o Causes mapped to each ICD iteration to capture all possible codes in available data for each cause 7

Redistribution of Garbage Codes

Unspecified Stroke

Heart Failure

Cardiovascular Deaths

Cardiovascular Deaths

Cardiovascular Deaths – 50 to 69 years

Cardiovascular Deaths – 70+ years

Risk Factors

Risk Factors – Systolic Blood Pressure Exposure

Risk Factors – LDL Cholesterol Exposure

Risk Factors - Smoking Exposure

Risk Factors – Fasting Plasma Glucose Exposure

Global Burden of Disease • Results visualization: o https://vizhub.healthdata.org/gbd-compare/ • Results query tool: o http://ghdx.healthdata.org/gbd-results-tool • Input data sources: o http://ghdx.healthdata.org/gbd-2017/data-input-sources

Global Burden of Disease

Global Burden of Disease • Results visualization: o https://vizhub.healthdata.org/gbd-compare/ • Results query tool: o http://ghdx.healthdata.org/gbd-results-tool • Input data sources: o http://ghdx.healthdata.org/gbd-2017/data-input-sources

Thank you