A genetic map of the People of the British Isles Walter Bodmer - PowerPoint PPT Presentation

PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com A genetic map of the People of the British Isles Walter Bodmer Weatherall Institute of Molecular Medicine and Department of Oncology University of Oxford

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PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com • Funded by the Wellcome Trust • Collect 4000+ samples- rural all 4 GPs from same area • Genotype subset of 2000 on 600,000 SNPs • Create genetic map of British Isles • A resource for future disease association studies

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2,039 samples PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com 500K SNPs Clustered using genetics Unlinked loci (PCA) Plotted on map

PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com 0.178 0.128 0.178x0.128 = 0.023 0.071 LD = 0.071 – 0.023 = 0.048 Proportion of HF due to LD = 0.048/0.071 = 0.68

An analysis of fine-scale population structure in a UK PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com control population Stephen Leslie, Garrett Hellenthal, Simon Myers, Dan Lawson, Daniel Falush, Peter Donnelly.

Orkne y Isl a nds Western Isl e s PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com Highland Grampian Loch Ericht Tayside Loch Ta y Loch Earn Central Fife Loch Lomond Car ron Valley Reser voir Lothian Strathclyde Borders Loch Doon Northumbe r lan d D umfries and G a l loway Tyn e and Wear N or thern Ire l a nd D urham Hartlepool C umbria Stockton−on−Tees D arlington Middlesbrough R edcar and Cle veland North Yorkshir e York East Riding of Yorkshire Lancashire Blackpool Kingston u pon Hu l l, C ity of West Yor ksh e i r Blackburn with Dar w en North Lincolnshir e North East Lincolnshir e Gr eater Manchester South Yorkshire Mer seyside Warring ton Halton Cheshire Der bysh i r e N ottinghamshire Lincolnshire Clwyd Stoke −on − T rent N ottingham Gw ynedd erby D Staffordshire Telford and Wr ekin Norfolk Leicester shire Rutland Shro pshire Leicester Pe terbo rough We st Midlands Cambridgeshire Powys Northamptonsh i r e Warwickshire Suffolk Worcestershir e County of Her efordsh i r e Milton Keynes Bedfordshire Dyfed Luton Gloucester shire Hertfor dshire Essex Buckinghamshire Oxfor dshire Gwent West Glamorgan Mid Glamor gan Swindon Southend−on−Sea South Gloucester shire Thurr ock Slough G r eater Londo n Windsor and Maidenh ead South Glamor gan Bristol, City of Reading Medway West Berkshire Wokingha m Bracknell Forest N or th Somerset Bath and N or th East Somerset Wiltshire Sur rey Kent Somer set Hampshire West Sussex East Sussex So uthampto n Brighton and Hove Portsmouth Dorset De von Bournemo uth Poole Isle of Wight Cornw all and Isles of Scilly Tor bay Pl ymouth

Ork ney Island s PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com Wester n Isles Highland Grampian Loch E r icht Tays ide Loch Tay Lo c h Earn Central Fife Loch L omo nd Carron Valley Reser v o ir Lothian Strath c lyde Borders Loch Doo n Northumberlan d Dumfries an d Gallo way Tyne and Wear Northern Irela nd Durha m Ha rtlepool Cumbria Stock ton −on−T e es Darlingto n Mid dlesbrough Redcar and Cle veland North Y o rk shire ork Y East Riding o f York shire La nc a s hir e B lac kpoo l K ingston upon Hull, City of West Y o rk shire Black b urn with Darw en North Lincolnshire North East Lincoln s hir e Gr e ater Manchester South Y orks h ire Merseyside Warrington Halto n Ch es h ire Derbyshire Nottingha mshire L incolnshire Clwy d Stoke−on −Trent Gwy ne dd Nottingham De r b y S taffordshire Telford a nd Wrek in Norfolk Le ic e s tershire Rutland Shropshire L eices ter eterborough P West Midlands Cambridge s hir e Powys Northampto ns hir e Warwick shire Suffolk Worcestershire County of Herefo r d s hir e Milton Keynes Bedfo r d s hir e Dyfe d Luton Her tfordshire Glouces tershire E ssex Buck inghams h ire Oxfo r d s hir e Gwent West Glamo r g an Mid Glamorgan Swindon ou then d−on −Sea S South Glou c esters h ire S lo ugh Th urr o c k Greater L ondon Windsor an d Maide nhead South Glamorgan B r is tol, City o f West Ber k shire Read ing Medw ay Wok ingham ra c B knell Forest North S o merset B a th and Nor th Eas t S omerset Wilts h ire Surrey K e nt Somers e t Hampshire West S u s se x East Suss e x Southampton Brighton a nd Ho ve Ports mouth Dors e t Dev on Poole B o urnemouth Is le of Wight Torbay Cor nwall and Isles of Sc illy P ly mouth

Orkney Is lands PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com Wester n Isles Highland Grampian Loch Er icht Tay side Loch Tay Loch Ear n Centr al Fife Loch Lomond Carron Valley Reser voir Lothian Strathclyde Borders Loch Doon Nor thumberland Dum fries and Galloway Tyne and Wear Northern Ireland Durham Hartlepool Cumbr ia Darlington Stockton−on−Tees Redcar and Cleveland Middlesbrough North Y orks hire York East Riding of Yorkshire Lanc ashire Blackpool K ingston upon Hull, City of West Y orks hire Blackbur n with Darwen Nor th Lincolnshire North East Lincolnshire Greater Manchester South Yorkshire Merseyside Warr ington Halton Cheshire Derbyshire Nottinghamshire Lincolnshire Clwyd Stoke−on−Trent Gwynedd Nottingham Derby Staffordshire Telford and Wrekin Norfolk Leic estershire Rutland Leicester Shropshire Peterborough West Midlands Cambridgeshire Powys Warwickshire Nor thamptonshire Suffolk Worcestershire County of Heref ordshire Milton Keynes Bedfordshire Dyfed Luton Her tfords hire Gloucestershire Essex Buckinghamshire Oxfordshire Gwent West Glamorgan M id Glamorgan Swindon Southend−on−Sea South Gloucestershire Slough Greater London Thurroc k Windsor and Maidenhead South Glamorgan B r istol, City of West Berkshire Reading Medway Wokingham Bracknell Forest North Somerset B ath and Nor th East Somerset Wiltshire Surrey ent K Somerset Ham pshire West Sussex Eas t Sussex Southampton Brighton and Hove Portsmouth Dorset Devon Poole B our nemouth Is le of Wight Cor nwall and Isles of Scilly Torbay Plymouth

Orkney Islands PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com Western Isles Highland Grampian Loch Ericht Tayside Loch Tay Loch Ear n Central Fife Loc h Lomond Carron Valley Reser voir Lothian Strathclyde Borders Loch Doon Northumberland Dumfries and Galloway Tyne and Wear Northern Ireland Durham Hartlepool Cumbr ia Stockton−on−Tees Redcar and Cleveland Darlington Middlesbrough North Y orkshire Y ork East Riding of Yor k shire Lanc ashire Blac kpool Kingston upon Hull, City of West Y orkshire Blackbur n with Darwen Nor th Lincolnshire Nor th East Lincolnshire Greater Manchester South Y or ks hire Merseyside Warr ington Halton Cheshire Derbyshire Nottinghamshire Lincolnshire Clwyd Stoke−on−Trent Nottingham Gwynedd Derby Staffordshire Telford and Wrekin Norfolk Leicestershire Rutland Shropshire Leic ester Peterborough West Midlands Cambr idgeshire Powys Nor thamptonshire Warwickshire Suffolk Worces tershire County of Heref ordshire Milton Key nes Bedfordshire Dy fed Luton Hertfordshire Glouc estershire Essex Buckinghamshire Oxfordshire Gwent West Glamorgan Mid Glamorgan Swindon Southend−on−Sea South Gloucestershire Thurrock Slough Greater London Windsor and Maidenhead South Glamorgan Br istol, City of West Ber kshire Reading Medway Wokingham Bracknell Forest North Somerset Bath and Nor th East Somerset Wiltshire Surrey Kent Somerset Hampshire West Sussex East Sussex Southampton Brighton and Hove Por tsmouth Dorset Dev on Poole Bournemouth Isle of Wight Torbay Cornwall and Isles of Scilly Plymouth