WP19 WP19 – PET FOR IN VIVO MONITORING PET FOR IN VIVO MONITORING AND THERAPY OPTIMIZATION Karolinska Institutet Stockholm, Sweden PARTNER Ki k Off M PARTNER Kick Off Meeting at CERN, 16-17 October 2008 ti t CERN 16 17 O t b 2008
Milestones and deliverables � 19-M1 Design of PET camera with Excentric Gantry. Design of PET camera that is fully integrated with a light ion Excentric Gantry allowing its use in four (m12) ( ) different treatment rooms. � 19-D1 Design of PET camera with Excentric Gantry. (m12, PP) � 19-M2 Dose delivery imaging. Study of the different advantages of dose delivery imaging using 11 C and 8 B versus 6 Li 10-11 B 12 C which are active PET emitters imaging using C and B versus Li, B, C which are active PET emitters versus stable nuclei. (m24) � 19-D2 Dose delivery imaging. Study of the different advantages of dose delivery imaging using 11 C and 8 B versus 6 Li, 10-11 B and 12 C. (m24, PP) � 19-M3 PET based light ion therapy. PET and PET-CT based light ion therapy planning and treatment optimisation. (m36) � 19-D3 PET based light ion therapy planning and treatment optimisation. (m36, PP) � 19-M4 Development of the full BIOART approach. Development of the full BIOART approach where biologically optimised 3D in vivo predictive assay is used together with ion beam IMRT. (m48) � � 19 D4 19-D4 Development of the full BIOART approach Development of the full BIOART approach. (m48 PP) (m48, PP) 2
WP19 D1 - Design of PET camera with Excentric Gantry Artist impression of the excentric gantry design allowing dose delivery in several treatment rooms placed around it. A PET camera could be incorporated into the gantry in one of the treatment rooms. (Brahme Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):603-16)
WP19 D2 - Dose delivery imaging using 11 C and 8 B versus 6 Li, 10-11 B and 12 C Comparison of the PET activity induced by 12 C PET image of the three-dimensional in and 11 C ion beams in water. A considerably vivo dose delivery distribution. Positron higher sensitivity to detect the primary carbon emitters 11 C and 15 O are produced ion Bragg peak with 11 C beam is clearly seen ion Bragg peak with C beam is clearly seen. through nuclear reactions from 12 C and through nuclear reactions from 12 C and This is of considerable importance for 16 O (Brahme et al Med Phys. 2008 accurate in vivo dose delivery imaging far May;35(5):1670-81) beyond what can be done with 12 C.
WP19 D3 - PET based light ion therapy planning and treatment optimisation
WP19 D4 - Development of the full BIOART approach BIOART using PET-CT Imaging ( Brahme Acta Oncol 42 (2003 ) 123.)
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