The Continuous Update Project: concept, purpose, methods and - PowerPoint PPT Presentation

The Continuous Update Project: concept, purpose, methods and results Teresa Norat August 27-30 2012 Montreal, Canada

Continuous Update Project • Keep Report updated into the future • WCRF/AICR working with team at • Same principles: - Systematically review evidence - Meta analysis - Panel of experts - draw conclusions - make recommendations • Various outputs

Continuous Update Project

MEMBERS AND OBSERVERS OF THE CUP PANEL Anne McTiernan, MD, PhD q Alan Jackson (Chair) Fred Hutchinson Cancer q CBE,MD,FRCP,FRCPCH,FRCPath Research Center Seattle, WA, University of Southampton,UK USA Elisa Bandera, MD, PhD Hilary J Powers, PhD RNutr q q The Cancer Institute of New Jersey University of Sheffield, UK United States Elio Riboli (Observer) Stephen Hursting PhD MPH q q MD, HonFPH, FMedSci University of Texas Austin, TX, USA Imperial College London,UK John Milner, PhD (Observer) q Ricardo Uauy, MD PhD National Cancer Institute q Instituto de Nutricion y Tecnologia Bethesda, MD United States de los Alimentos Santiago, Chile

The Continuous Update Project – rolling programme CANCER TYPES 3 3 3 3 3 3 3 3 3 3 1 2 3 4 5 6 7 8 9 3 3 3 3 3 3 3 3 3 3 17 CANCERS AND CANCER YEAR SURVIVORS 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2007 BREAST 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2008 BREAST PROSTATE 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 COLON 2009 BREAST PROSTATE AND RECTUM 3 3 3 3 3 3 3 3 3 3 BREAST 3 3 COLON 3 3 3 3 3 3 3 3 2010 PANCREAS BREAST PROSTATE CANCER AND SURVIVORS RECTUM 3 3 3 3 3 3 3 3 3 3 3 3 3 3 BREAST 3 3 3 3 3 3 COLON 2011 BREAST PROSTATE PANCREAS CANCER AND ENDOMETRIUM OVARY SURVIVORS RECTUM 3 3 3 3 3 3 3 3 BREAST 3 3 3 3 3 3 COLON 2012 BREAST PROSTATE PANCREAS CANCER ENDOMETRIUM OVARY BLADDER KIDNEY AND SURVIVORS RECTUM

CUP Database CUP database CUP Team

Strategic decisions 1. Updating the database: � Cohort studies, case-control studies nested in cohort studies � Randomised trials � Peer-reviewed journals (English language) � References and abstracts of Ref Man (Identifiers) other relevant studies

Strategic decisions 2. When to update a meta-analysis? � Three or more publications added after the 2007 second expert report � By recommendation of the Panel

Number of articles from cohort studies in the CUP database for selected cancers by publication period 62 41 Kidney 101 33 Bladder Search literature review 45 60 Ovary Second expert report (before 2006) 59 58 Endometrial Continuous update project (2006-2011) 121 82 Pancreas 236 154 Prostate 300 239 Colon 328 323 Breast 0 100 200 300 400 500 600 700

Diet and Cancer Report website http://www.dietandcancerreport.org

Colorectal cancer matrices 2007 and 2011 In 2011, the evidence that foods containing dietary fibre modify the risk of colorectal cancer was upgraded from probable to convincing

Colorectal cancer and dietary fibre per 10 g increase CUP ¡Colorectal ¡cancer ¡report ¡2010 ¡ ¡ ¡ BMJ ¡2011;343:d6617 ¡doi: ¡10.1136/bmj.d6617 ¡ ¡

Colorectal cancer and dietary fibre (by food source) CUP ¡Colorectal ¡cancer ¡report ¡2010 ¡ ¡ ¡ BMJ ¡2011;343:d6617 ¡doi: ¡10.1136/bmj.d6617 ¡ ¡

Colorectal cancer and whole grain foods CUP ¡Colorectal ¡cancer ¡report ¡2010 ¡ ¡ ¡ BMJ ¡2011;343:d6617 ¡doi: ¡10.1136/bmj.d6617 ¡ ¡

Colorectal cancer, fruits and vegetables Highest ¡ ¡vs ¡Lowest ¡ Dose-­‑response ¡(per ¡100 ¡grams) ¡ Colorectal ¡cancer ¡report ¡2010 ¡ ¡Gastroenterology ¡2011 ¡h6p://dx.doi.org/10.1053/j.gastro.2011.04.013 ¡ ¡

Colorectal cancer, red and processed meats CUP ¡Colorectal ¡cancer ¡report ¡2010 ¡PLoS ¡One ¡2011;6(6):e20456 ¡

ICL Team Journal Publications Colorectal cancer q Carbohydrates, glycemic index, glycemic load Cancer Causes Control. 2012 Apr;23(4):521-35 q Dietary fibre, whole grains BMJ. 2011 Nov 10;343:d6617. doi: 10.1136/bmj.d6617 q Red and processed meat PLoS One. 2011;6(6):e20456 q Dairy products Ann Oncol. 2012 Jan;23(1):37-45 q Fruits and vegetables Gastroenterology. 2011 Jul;141(1):106-18 q 25-hydroxyvitamin D status Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):1003-16

ICL Team Journal Publications Breast cancer q Dietary and blood carotenoids Am J Clin Nutr. 2012 Jul 3 q Fruits and vegetables Breast Cancer Res Treat. 2012 Jun 16 q Dietary fiber Ann Oncol. 2012 Jun;23(6):1394-402 Pancreatic cancer q Height. Cancer Causes Control. 2012 Jun 12 q Dietary fructose, carbohydrates, glycemic index Ann Oncol. 2012 Apr 26 q Body mass index, abdominal fatness Ann Oncol. 2012 Apr; 23(4):843-52

Breast cancer and dietary fibre (by food source) Ann ¡Oncol ¡2012;23:1394-­‑1402 ¡

What next? Breast cancer survivors. Mortality, second cancers (Nov 2012)

What next? Reports on endometrial and ovarian cancer (October 2012) ICL 2011 2012 2013 2014 2015 2016 Timeline: JanFeb Mar AprMay JunJul Aug Sep OctNov Dec JanFeb Mar AprMay JunJul Aug Sep OctNov Dec JanFeb Mar AprMay JunJul Aug Sep OctNov Dec JanFeb Mar AprMay JunJul Aug Sep OctNov Dec JanFeb Mar AprMay JunJul Aug Sep OctNov Dec JanFeb Mar AprMay JunJul Aug Sep OctNov Dec Cancers Breast Prostate Colorectal Adenomas Pancreas Breast Ca Surv Endometrium Ovary Kidney Bladder Liver Gallbladder Stomach Oesophagus MPL Nasopharynx Lung Skin Cervix Protocol Updating Database Continuous Update Report first draft Report review Report discussed by Panel Panel meeting

CUP Team Ana Rita Vieira Thanks! Rui Vieira Teresa Norat Doris Chan Deborah Navarro Rosenblatt Dagfinn Aune Doris Chan Darren Greenwood, University of Leeds, Statistical Advisor (not in photo)