Supplementary Figure 1. LNA-FISH analysis demonstrates increased - PowerPoint PPT Presentation

Jun 11, 2023 •148 likes •186 views

Supplementary Figure 1. LNA-FISH analysis demonstrates increased miRNA-196a signals in a PanNET (A) compared to non-neoplastic endocrine cells (B) and acinar cells (C). B A C PanNET Endocrine cells Acinar cells Supplementary Figure 2.

Supplementary Figure 1. LNA-FISH analysis demonstrates increased miRNA-196a signals in a PanNET (A) compared to non-neoplastic endocrine cells (B) and acinar cells (C). B A C PanNET Endocrine cells Acinar cells
Supplementary Figure 2. Results of ROC analyses. High tumoral miRNA-196a levels significantly discriminated between recurrent and non-recurrent PanNETs with a cut-off level of 1.279 (A). miRNA-27b levels showed similar results but with a lower specificity (B), and miRNA-142–5p levels did not appear to significantly discriminate between recurrent and non-recurrent PanNETs (C). miR-196a miR-27b miR-142-5p sensitivity sensitivity sensitivity Cutoff value = 0.929 Cutoff value = 1.279 Cutoff value = 0.378 A Sensitivity = 50.0% Sensitivity = 83.3% Sensitivity = 83.3% Specificity = 71.0% Specificity = 71.0% Specificity = 83.9% AUC= 0.543 AUC= 0.833 AUC = 0.747 P=0.742 P=0.058 P=0.011 1-specificity 1-specificity 1-specificity
Supplemental Digital Content 3. Cox regression analysis for the recurrence of PanNET Adjusted Hazard Crude Hazard Ratio Ratio Variable 95% CI P 95% CI P on Univariable on Multivariable Analysis Analysis miR-27b* 7.637 0.853-68.338 0.069 6.697 0.736-60.903 0.091 (low/high) miR-142-5p* 3.189 0.623-16.336 0.164 (low/high) miR-196a* 16.267 1.732-152.789 0.015 20.299 2.322-177.413 0.006 (low/high) *Cut-off values for miR-27b (0.378), miR-142-5p (0.9285) and miR-196a (1.279) levels were derived from ROC curves.

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