Summary of Changes Slide 36 graph Should be labeled 4mcg/ml and 2 - PowerPoint PPT Presentation

Summary of Changes • Slide 36 – graph – Should be labeled 4mcg/ml and 2 mcg/ml NOT 2mcg/ml and 1 mcg/ml – Half-life still 7.5 hours • Slide 38 – Substitute 4 mcg/ml for 2mcg/ml and 2 mcg/ml for 1mcg/ml – Answer is still the same

GRAPH OF GENTAMICIN PLASMA CONCENTRATION vs.TIME 10.0 6.2 4 mcg/ml Gentamicin Plasma Conc. t 1/2 = 7.5 h 2.5 2 mcg/ml (mcg/ml) 1.2 1.0 0.1 0 2 4 6 8 1 0 1 2 1 4 1 6 1 8 20 22 24 Time Post End of Infusion (hours) 6h 13.5h

Elimination Rate Constant (k) Elimination Rate Constant (k) • k is the (-) slope of the “Natural Log (LN) Concentration versus Time Plot” Δ Y axis - (LN(4) - LN(2) ⇒ ⇒ (-) slope = Δ X axis - (6 -13.5) LN(2) – LN(4) ⇒ ⇒ Simplifying k = 13.5 - 6 - LN(4/2 ) k = LN(2) = 0.693 = 0.09 hr k = 7.5hr 7.5 hr 7.5 hr