Stop Vivisection ECI(2012)000007 Ray Greek MD Board Certified - PowerPoint PPT Presentation

Stop Vivisection ECI(2012)000007 Ray Greek MD Board Certified Anesthesiology Added Qualification Pain Management

1. Animals as predictive models for disease 2. Animals as predictive models for drug testing 3. Animals as spare parts Predictive 4. Animals as factories value 5. Animal tissue to study basic physiological principles 6. Animals for dissection in education 7. Animals as a modality for ideas (are heuristic) 8. To benefit other animals 9. Knowledge for knowledge sake

Evolution

Complexity Science

Complex systems are highly dependent on initial conditions

Empirical Evidence

 In vivo animal does not predict in vivo human  Adv. Drug Deliv. Rev ., 54: 433-451, 2002.

Personalized Medicine  Matching an individual’s genes to disease and drugs  No more “one size fits all”  Men v women  Ethnic groups  Monozygotic (identical) twins  A majority of drugs are either ineffective of not tolerated in most humans

Trans-Species Modeling Theory  While trans-species extrapolation is possible when perturbations concern lower levels of organization or when studying morphology and function on the gross level, one evolved, complex system will not be of predictive value for another when the perturbation affects higher levels of organization.

ECI(2012)000007 CONCERNS BOTH SCIENCE AND ETHICS

If animal models have no predictive value for human response to drugs and disease then vivisection is not a necessary evil

Debate b) A panel of judges will be present. They may come from academia or industry. The judges should include experts from the fields of clinical medicine, complexity/chaos theory, philosophy of science, evolutionary biology, clinical research, drug development, predictive value, and the differences between applied and basic research. Both debaters must agree on each of the judges.  http://www.afma-curedisease.org/speaking-engagements.aspx