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SOLI SO LID O D ORG RGAN ANIC C PE PERF RFOR ORMAN ANCE CE Merck KGaA, Darmstadt, Germany Q2 2018 results Stefan Oschmann, CEO Marcus Kuhnert, CFO Udit Batra, CEO Life Science August 9, 2018 Disclai laimer mer Publication of


  1. SOLI SO LID O D ORG RGAN ANIC C PE PERF RFOR ORMAN ANCE CE Merck KGaA, Darmstadt, Germany Q2 2018 results Stefan Oschmann, CEO Marcus Kuhnert, CFO Udit Batra, CEO Life Science August 9, 2018

  2. Disclai laimer mer Publication of Merck KGaA, Darmstadt, Germany. In the United States and Canada the group of companies affiliated with Merck KGaA, Darmstadt, Germany operates under individual business names (EMD Serono, Millipore Sigma, EMD Performance Materials). To reflect such fact and to avoid any misconceptions of the reader of the publication certain logos, terms and business descriptions of the publication have been substituted or additional descriptions have been added. This version of the publication, therefore, slightly deviates from the otherwise identical version of the publication provided outside the United States and Canada. 2

  3. Disclaimer Cautionary Note Regarding Forward-Looking Statements and financial indicators This communication may include “forward -looking statements. ” Statements that include words such as “anticipate,” “expect,” “should,” “would,” “intend,” “plan,” “project,” “seek,” “believe,” “will,” and other words of similar meaning in connection with future events or future operating or financial performance are often used to identify forward-looking statements. All statements in this communication, other than those relating to historical information or current conditions, are forward-looking statements. We intend these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements in the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to a number of risks and uncertainties, many of which are beyond control of Merck KGaA, Darmstadt, Germany, which could cause actual results to differ materially from such statements. Risks and uncertainties include, but are not limited to: the risks of more restrictive regulatory requirements regarding drug pricing, reimbursement and approval; the risk of stricter regulations for the manufacture, testing and marketing of products; the risk of destabilization of political systems and the establishment of trade barriers; the risk of a changing marketing environment for multiple sclerosis products in the European Union; the risk of greater competitive pressure due to biosimilars; the risks of research and development; the risks of discontinuing development projects and regulatory approval of developed medicines; the risk of a temporary ban on products/production facilities or of non-registration of products due to non-compliance with quality standards; the risk of an import ban on products to the United States due to an FDA warning letter; the risks of dependency on suppliers; risks due to product- related crime and espionage; risks in relation to the use of financial instruments; liquidity risks; counterparty risks; market risks; risks of impairment on balance sheet items; risks from pension obligations; risks from product-related and patent law disputes; risks from antitrust law proceedings; risks from drug pricing by the divested Generics Group; risks in human resources; risks from e-crime and cyber attacks; risks due to failure of business-critical information technology applications or to failure of data center capacity; environmental and safety risks; unanticipated contract or regulatory issues; a potential downgrade in the rating of the indebtedness of Merck KGaA, Darmstadt, Germany; downward pressure on the common stock price of Merck KGaA, Darmstadt, Germany and its impact on goodwill impairment evaluations and the impact of future regulatory or legislative actions. The foregoing review of important factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included elsewhere, including the Report on Risks and Opportunities Section of the most recent annual report and quarterly report of Merck KGaA, Darmstadt, Germany. Any forward-looking statements made in this communication are qualified in their entirety by these cautionary statements, and there can be no assurance that the actual results or developments anticipated by us will be realized or, even if substantially realized, that they will have the expected consequences to, or effects on, us or our business or operations. Except to the extent required by applicable law, we undertake no obligation to update publicly or revise any forward-looking statement, whether as a result of new information, future developments or otherwise. This quarterly presentation contains certain financial indicators such as EBITDA pre exceptionals, net financial debt and earnings per share pre exceptionals, which are not defined by International Financial Reporting Standards (IFRS). These financial indicators should not be taken into account in order to assess the performance of Merck KGaA, Darmstadt, Germany in isolation or used as an alternative to the financial indicators presented in the consolidated financial statements and determined in accordance with IFRS. The figures presented in this quarterly statement have been rounded. This may lead to individual values not adding up to the totals presented. 3

  4. Agenda Executive summary Financial overview Business deep dive Guidance 4

  5. EXECUTI CUTIVE VE SUMMARY ARY

  6. Highlights Healthcare – Solid organic sales growth, Mavenclad U.S. submission accepted by FDA (approved in 38 countries) Life Science – Continued strong organic sales performance across all businesses Operations Performance Materials – Strong growth of Semiconductor Solutions and OLED, mitigated by ongoing LC decline Org. sales growth of 5.2%; Org. EBITDA pre decline of -2.7% Financials H1 org. sales growth of 4.2%; H1 org. EBITDA pre decline of -6.2% 1 – net sales: €14.1 -14.6 bn & EBITDA pre: €3,750 - FY 2018 guidance confirmed 4,000 m 1 Guidance excludes Consumer Health 6

  7. Strong organic growth in Life Science and Healthcare almost offset by FX Q2 2018 YoY net sales • Healthcare driven by solid growth of core business and increasing contribution from Organic Currency Portfolio Total Mavenclad and Bavencio launches Healthcare 4.7% -4.9% 0.0% -0.2% • Life Science’s above -market growth driven by all business segments Life Science 7.7% -4.6% 0.0% 3.2% • Flat Performance Materials due to growth of Performance Materials 0.4% -4.6% 0.0% -4.2% Semiconductor, compensating declining Display Group 0.0% 0.5% 5.2% -4.7% Q2 YoY EBITDA pre • Organic decline of EBITDA pre explained by €1,066 m Healthcare’s LY one time effect, higher launch -2.7% -11.0% 0.0% €920 m and R&D investments and PM business mix • Currency effects mainly related to EUR/USD development Q2 2017 Organic Currency Portfolio Q2 2018 7 Totals may not add up due to rounding

  8. Organic growth driven by LATAM, APAC, Europe and North America Regional breakdown of net sales [€ m] Regional organic development Europe • Solid growth in Europe reflects Mavenclad +5.2% org. ramp up, Fertility resilience, and solid demand in Life Science 31% • Solid growth in North America from Life Science; Bavencio and Fertility North America overcompensating declining Rebif +4.3% Q2 2018 org. • Solid growth in APAC due to strong Life Net sales: Science and Glucophage in China, €3,714 m 33% 26% Semiconductor outweighing LC decline Asia-Pacific +5.9% org. • Strong performance in LATAM across all major businesses 7% 3% • MEA reflects flat LS, PM and decline in HC Latin America +16.9% Middle East & Africa -13.3% org. org. 8 Acronyms: MEA – Middle East & Africa; LATAM – Latin America

  9. FIN INANCIAL NCIAL OVERVI VIEW EW

  10. Q2 2018: Overview Key figures Comments Q2 2017 Q2 2018 Δ [€m] • EBITDA pre & margin reduction mainly driven by LY milestone in Healthcare and Net sales 3,695 3,714 0.5% ongoing LC decline 920 -13.7% EBITDA pre 1,066 • Lower EPS pre driven by EBITDA pre 28.9% 24.8% Margin (in % of net sales) decline • Operating cash flow impacted by higher EPS pre 1.51 1.23 -18.5% working capital 367 -29.3% Operating cash flow 520 • Net financial debt increase reflects lower operating cash flow amid dividend payment Dec. 31, 2017 June 30, 2018 Δ • Working capital reflects organic sales [€m] growth 10,674 5.2% Net financial debt 10,144 3,677 8.5% Working capital 3,387 * 54,009 2.0% Employees 52,941 * Thereof CH Headcount ~3.400; 10 Totals may not add up due to rounding

  11. Reported figures Reported results Comments Q2 2017 Q2 2018 Δ [€m] • Lower EBIT in line with EBITDA pre EBIT 608 decrease; LY EBIT included Vevey write- 392 -35.4% up (~ €70 m) Financial result -66 -65 -1.8% • Profit before tax in line with EBIT decrease Profit before tax 542 328 -39.5% • Effective tax rate within guidance range -35.4% Income tax -130 -84 of ~24-26% 25.5% Effective tax rate (%) 23.9% * Net income 426 247 -42.0% * EPS (€) 0.98 0.57 -41.8% * From continuing and discontinued operations; 11 Totals may not add up due to rounding

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