Rob Currie rcurrie@ucsc.edu Genetic Data: 1 in 25 Americans BRCA 1 - PowerPoint PPT Presentation

Rob Currie rcurrie@ucsc.edu

Genetic Data: 1 in 25 Americans

BRCA 1 & 2 Familial Breast Cancer No Familial Breast Cancer General Population

ATM BARD1 From 2 to All Genes BRIP1 CDH1 CHEK2 MLH1 MSH2 MSH6 BRCA1 PMS2 BRCA2 EPCAM 50%+ NBN 5% NF1 VUS PALB2 VUS PTEN RAD51C RAD51D STK11 TP53

Most Biomedical Data Held in Silos

We need a network for sharing GATTTATCTGCTCTCGTTG GAAGTACAAAATTCATTAAT GCTATGCACAAAATCTGTAG C TAGTGTCCCATCTATTT

Users Researchers, Clinicians, Pharma, Data Analysts, Citizen Scientists Cancer Gene Trust Public Public Public Data Data Data Patient Steward Steward Patient Steward Patient Participants Lab UCSF Participants BRCA Participants Private Private Private Data Data Data

Moving Compute to the Data Containers CGT Container Hash $$$ Steward Steward Encrypted Results Private Private Data Data

Somatic Genomic Data Docker Containers

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Unlocking life’s code.