Propensity Analysis Major Depressive Disorder Collaborative - PowerPoint PPT Presentation

Propensity Analysis

Major Depressive Disorder • Collaborative Depression Study • 25 year naturalistic follow up • Bias reduction in effectiveness analyses of longitudinal ordinal doses with a mixed- effects propensity adjustment • Adjusts for susceptibility bias Leon et al. Am J Psychiatry 2003; 160:727–733

Odds of Recovery from MDD Episode Compared to No Treatment Odds Ratio p=.002 2 Controlled for propensity 1.8 for treatment intensity 1.6 1.4 p=.35 1.2 p=.51 1 0.8 0.6 0.4 0.2 0 High Medium Low Intensity of Somatic Treatment Leon et al. Am J Psychiatry 2003; 160:727–733

Odds of Relapse with MDD Episode Compared to No Treatment Odds Ratio Controlled for propensity 1.2 for treatment intensity p=.929 1 0.8 p=.055 0.6 p=.009 0.4 0.2 0 High Medium Low Intensity of Somatic Treatment Leon, Hedeker, Teres. Statist. Med. 2007; 26:110–123