Program Initiatives 3 CBCRP Council Meeting June 7, 2019 CBCRP - PowerPoint PPT Presentation

Updates on Program Initiatives 3 CBCRP Council Meeting June 7, 2019

CBCRP Program Initiatives 2000 2005 2010 2015 2020 2025 Special • 9 sub-initiatives • Environmental PI1 • 26 grants Research effects • ~ $21 million • Health disparities Initiatives (SRI) • Environmental causes California Breast • 15 sub-initiatives PI2 • Health disparities Cancer Prevention • 18 grants to date • Population-level interventions • ~ $17 million to date Initiatives (CBCPI) • Targeted interventions Program • Environmental contributors PI3 Initiatives 3 • Health disparities • Population-level prevention interventions (PI3)

Program Initiative Process 2000 2005 2010 2015 2020 2025 Synthesize Compete Collect & & Ideas Prioritize Fund Synthesize Compete Collect & & Ideas Prioritize Fund Synthesize Compete Collect & & Ideas Prioritize Fund

PI3 Focus Areas • Identify and eliminate environmental contributors to breast cancer. • Identify and eliminate fundamental causes of health disparities with a focus on breast cancer in California. • Develop and test population-level prevention interventions that incorporate approaches that address the needs of the underserved and/or populations experiencing disparities in the burden of breast cancer.

Recent Activities • March 22/25: Calls with PI3 Steering Committee/Strategy Advisors to refine Environment and Disparities topic lists • April: Delphi survey to prioritize Environment and Disparities topics • May 15: Global Challenge Event Showcase and Competition • May 15-16: PI3 Steering Committee/Strategy Advisor meeting Upcoming activities: • June: Steering Committee meeting to select first round of topics • Rest of 2019: Concept paper development • March/April 2020: Next PI3 Steering Committee/Strategy Advisor meeting

Delphi Survey (April 2019) • Iterative multi-round process that aids decision-making because respondents see first-round results from group before participating in second round. • Round 1: – Rate each topic on: • How well does the research topic increase knowledge and potentially create solutions? • How will the research dramatically change how or what breast cancer research is conducted in the next decade? • How does the research address special interest in California? • Round 2 (after seeing results from Round 1) : – Rank top 10 ideas – Weighted Ranking: allocate 100 points across ideas – Which 5 topics would you eliminate?

Delphi Survey Results: Environmental Contributors

Delphi Survey Results: Health Disparities

SC+SA Meeting Outcomes: May 15-16, 2019 • Initial road map of research topics for PI3 (3 years). Steering Committee and Strategy Advisors will continue to refine • List of research topics for first round of concept papers (drafts by for Feb 2020) – Initial volunteers to serve on concept paper workgroups – Steering Committee to decide which topics to pursue and refine concept paper workgroups • List of research topics needing additional research or refinement by February 2020 to determine if they should advance • Feedback on the fund allocation strategy – Steering Committee to further refine

Next Steps • May/June: Steering Committee members/Strategy Advisors refining batch 1 topics • June: Steering Committee meets to select batch 1 topics • July – February 2020: Batch 1 concept paper development • March/April 2020: SC+SA meeting to discuss concept papers

Topics for Concept Paper Batch 1 Environmental Contributors Health Disparities Population-Level Prevention It is anticipated that two J – Shift Work and Other A - Inflammation, Breast environmental topics will be Social Environmental Factors Density, Thermography (9 determined for batch #1 after (6 votes) votes) further refinement. A – Life Stressors (5 votes) P+G+H - Community-Level W+T – Biomonitoring with Intervention/ CLASP Mixtures (5 votes + 1 vote for Proposal (8 votes) Letters add exposome) refer to Health Disparities original list AA+BB – Implementation Research and Policy (5 votes) O – Three-Generation (4 votes) C+Q – Chemical Testing. Hallmarks of Cancer / Chemical Causing Cancer (4 votes)

Likely Topics for Concept Paper Batches 2 and 3 Environmental Health Disparities Population-Level Contributors Prevention G – Occupational Cohort (4 B+C – Differences in B – Inflammatory votes) Immigrant Groups (2 Pathway in an votes) Intervention (3 votes) D+T – Chemical Testing with Mixtures (1 votes) G – Add Generational Trends to CA Breast F – Consumer Products (3 Cancer Primary votes) Prevention Plan(0 votes)

Topics that Require Refinement or Research before Advancing Environmental Health Disparities Population-Level Contributors Prevention Need to be refined Need to be refined A – Searchable Inventory H – Recruitment for Policy, Research Funding, CC – Behavioral/Social Advocacy Science Intervention Need more research V – Ductal Lavage D – Bovine (BLV) Need more research P+Q: Microbiome and Inflammation