Practical work I provide you a Matlab code that implements the - PDF document

Lesson 16 University of Bergamo Engineering and Management for Health FOR CHRONIC DISEASES MEDICAL SUPPORT SYSTEMS LESSON 16A Artificial pancreas: mathematical model of automatic blood glucose control. Ettore Lanzarone April 29, 2020 Practical work I provide you a Matlab code that implements the insulin model according to Want et al. (2014).

Lesson 16 Practical work In the provided implementation: 1. Random generation of input carbohydrates being taken 2. Fixed insulin injection at given time instants 3. Autoregressive parameters assigned Look at the code and compare with your previous implementation. Are they equivalent (not equal)? Practical work Look at the outcomes and try to modify the parameters in order to obtain output glucose waveforms that are qualitative similar to those reported in the paper.

Lesson 16 Practical work You can in particular replace input variables (random input carbohydrates being taken and given insulin injection) with those of the picture and tune the output on this waveform. Respect the following constraints: 1) Coefficients β to be negative ( insulin always reduces glucose concentration ) 2) Coefficients γ to be positive ( carbohydrate always increases glucose concentration ) 3) Sum of coefficients ψ to be lower than 1 ( glucose in blood slightly reduces in the absence of other sources ) Practical work Now, come back to the random generation of input carbohydrates being taken. Look at the system behavior under: • A spike of insulin injection 3 times over the day • A constant release In both cases, the mean value of the release should be tailored in order to respect a cyclic behavior (e.g., end of day = begin of day). Anyway, due to the variability of the input carbohydrates, getting the previous task is rather impossible. It is possible “on average” over several replications.

Lesson 16 Practical work Anyway, due to the variability of the input carbohydrates, getting the previous task is rather impossible. It is possible “on average” over several replications. THIS SHOWS THE NEED OF A CONTROL LOOP University of Bergamo Engineering and Management for Health FOR CHRONIC DISEASES MEDICAL SUPPORT SYSTEMS LESSON 16B Project Ettore Lanzarone April 29, 2020

Lesson 16 Project Topic chosen among those presented during the course or on a dataset suggested by the student themselves and approved. Deadlines: • Group definitions CLOSED; PROVIDE Each group choose a component as leader for the administrative stuff. VARIATIONS NOW The leader will send a mail with the list of the names before the deadline. PROVIDE THE TOPIC; IN ALL CASES SEND • Topics AN OUTLINE WITH GOALS AND The leader will send a mail with the chosen topic. EXPECTED DATA If the topic is chosen by the group, it has to be presented in advance for approval. • Report and slides – 7 days before the discussion date THIS IS THE DEADLINE FOR THE FINAL The leader will send a mail with the attachments. SUBMISSION; ASK WHENEVER YOU NEED AND SEND DRAFTS IF A CHECK IS NEEDED